Access to highly specialized growth substrates and production of epithelial immunomodulatory metabolites determine survival of Haemophilus influenzae in human airway epithelial cells

Haemophilus influenzae (Hi) infections are associated with recurring acute exacerbations of chronic respiratory diseases in children and adults including otitis media, pneumonia, chronic obstructive pulmonary disease and asthma. Here, we show that persistence and recurrence of Hi infections are clos...

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Veröffentlicht in:	PLoS pathogens 2022-01, Vol.18 (1), p.e1010209-e1010209
Hauptverfasser:	Hosmer, Jennifer, Nasreen, Marufa, Dhouib, Rabeb, Essilfie, Ama-Tawiah, Schirra, Horst Joachim, Henningham, Anna, Fantino, Emmanuelle, Sly, Peter, McEwan, Alastair G, Kappler, Ulrike
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Amino acids Animal models Animals Asthma Bacterial infections Biology and Life Sciences Bronchopulmonary infection Carbon Carbon sources Causes of Chronic obstructive pulmonary disease Complications and side effects D-Lactate dehydrogenase Dehydrogenase Dehydrogenases Ear diseases Enzymes Epithelial cells Epithelium Gene expression Glucose Glycoproteins Haemophilus Infections - metabolism Haemophilus influenzae Haemophilus influenzae - metabolism Health aspects Hemophilus influenzae Host-parasite relationships Host-Pathogen Interactions - physiology Human tissues Humans Immunomodulation Immunomodulators Infections Inflammation Intercellular Signaling Peptides and Proteins - metabolism Kinases L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Lung diseases Medicine and Health Sciences Metabolism Metabolites Mice Nitrogen Obstructive lung disease Otitis media Pathogens Physical Sciences Research and Analysis Methods Respiration Respiratory diseases Respiratory Mucosa - metabolism Respiratory Mucosa - microbiology Respiratory tract Respiratory tract diseases Statistical significance Substrates
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