Human NAIP/NLRC4 and NLRP3 inflammasomes detect Salmonella type III secretion system activities to restrict intracellular bacterial replication

Salmonella enterica serovar Typhimurium is a Gram-negative pathogen that uses two distinct type III secretion systems (T3SSs), termed Salmonella pathogenicity island (SPI)-1 and SPI-2, to deliver virulence factors into the host cell. The SPI-1 T3SS enables Salmonella to invade host cells, while the...

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Veröffentlicht in:	PLoS pathogens 2022-01, Vol.18 (1), p.e1009718-e1009718
Hauptverfasser:	Naseer, Nawar, Egan, Marisa S, Reyes Ruiz, Valeria M, Scott, William P, Hunter, Emma N, Demissie, Tabitha, Rauch, Isabella, Brodsky, Igor E, Shin, Sunny
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biology and Life Sciences Calcium-Binding Proteins - immunology CARD Signaling Adaptor Proteins - immunology Caspase-1 Combinatorial analysis CRISPR Cytokines Flagellin Genetic aspects Health aspects Host-parasite relationships Humans Infections Inflammasomes Inflammasomes - immunology Interleukin 1 Intracellular Ligands Macrophages Macrophages - immunology Macrophages - microbiology Medicine and Health Sciences Neuronal Apoptosis-Inhibitory Protein - immunology NLR Family, Pyrin Domain-Containing 3 Protein - immunology Pathogenicity Pathogens Prevention Proteins Pyroptosis Recognition Replication Salmonella Salmonella Infections - immunology Salmonella typhimurium - immunology Salmonella typhimurium - pathogenicity Salmonellosis Type III Secretion Systems - immunology Virulence Virulence factors
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