New insights into the role of endosomal proteins for African swine fever virus infection

African swine fever virus (ASFV) infectious cycle starts with the viral adsorption and entry into the host cell. Then, the virus is internalized via clathrin/dynamin mediated endocytosis and macropinocytosis. Similar to other viruses, ASF virion is then internalized and incorporated into the endocyt...

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Veröffentlicht in:	PLoS pathogens 2022-01, Vol.18 (1), p.e1009784-e1009784
Hauptverfasser:	Cuesta-Geijo, Miguel Ángel, García-Dorival, Isabel, Del Puerto, Ana, Urquiza, Jesús, Galindo, Inmaculada, Barrado-Gil, Lucía, Lasala, Fátima, Cayuela, Ana, Sorzano, Carlos Oscar S, Gil, Carmen, Delgado, Rafael, Alonso, Covadonga
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidification African swine fever African Swine Fever - virology African Swine Fever Virus - metabolism African Swine Fever Virus - pathogenicity Animals Asfarviridae Biology and Life Sciences Cell organelles Chlorocebus aethiops Cholesterol Clathrin CRISPR Cytoplasm Distribution Drugs Dynamin Egress Endocytosis Endosomes Endosomes - metabolism Endosomes - virology Epidemics Fever Genetic aspects Health aspects HEK293 Cells Host-Pathogen Interactions - physiology Humans Infections Infectivity LAMP-1 protein Medicine and Health Sciences Membrane fusion Membrane proteins Membranes Multilayers Niemann-Pick disease Npc1 protein Nucleic acids Proteins Replication Research and Analysis Methods Severe acute respiratory syndrome coronavirus 2 Swine Vero Cells Viral Proteins - metabolism Virions Viruses
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