Heparin versus 0.9% sodium chloride intermittent flushing for preventing occlusion in newborns with peripherally inserted central catheters: A systematic review protocol
Mechanical factors are primary complications that justify early removal of a peripherally inserted central catheter, and thrombotic catheter occlusion is the most critical mechanical complication associated with loss of device functionality. Studies have investigated these factors in adult patients,...
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| Veröffentlicht in: | PloS one 2022-12, Vol.17 (12), p.e0278068 |
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| creator | Nascimento, Alice Passos do de Medeiros, Kleyton Santos Costa, Ana Paula Ferreira Sarmento, Ayane Cristine Cruz, Giovanna Karinny Pereira Gonçalves, Ana Katherine de Souza, Nilba Lima Costa da Silva, Maria de Lourdes |
| description | Mechanical factors are primary complications that justify early removal of a peripherally inserted central catheter, and thrombotic catheter occlusion is the most critical mechanical complication associated with loss of device functionality. Studies have investigated these factors in adult patients, but findings are not directly applicable to newborns. Therefore, systematic reviews focusing on this population are necessary for consolidated evidence to aid clinical practice.
This study aims to evaluate the efficacy of intermittent heparin washing versus 0.9% sodium chloride solution for preventing occlusion in newborns with peripherally inserted central catheters.
We will use the PubMed, Embase, Scopus, Web of Science, Cochrane Central Register of Controlled Trials, CINAHL, and Clinical Trial Databases for article search, without language or publication periods restrictions. Randomized clinical trials evaluating the use of intermittent heparin washing versus 0.9% sodium chloride solution in newborns with peripherally inserted central venous catheters will be included. The primary outcome will be peripherally inserted central catheter occlusion. Two reviewers will independently screen the studies, based on the inclusion criteria, extract the data for each included study and assess the risk of bias using the Cochrane risk of bias tool. The data will be synthesized using the Review Manager software (RevMan 5.4.1). To classify the strength of the evidence of results, we will use the Grading of Recommendations Assessment, Development and Evaluation Working Group (GRADE). The review was registered with PROSPERO (registration number CRD42021281509).
We expect that this study would reveal the best method for preventing catheter occlusion in newborns with peripherally inserted central catheters. |
| doi_str_mv | 10.1371/journal.pone.0278068 |
| format | Article |
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This study aims to evaluate the efficacy of intermittent heparin washing versus 0.9% sodium chloride solution for preventing occlusion in newborns with peripherally inserted central catheters.
We will use the PubMed, Embase, Scopus, Web of Science, Cochrane Central Register of Controlled Trials, CINAHL, and Clinical Trial Databases for article search, without language or publication periods restrictions. Randomized clinical trials evaluating the use of intermittent heparin washing versus 0.9% sodium chloride solution in newborns with peripherally inserted central venous catheters will be included. The primary outcome will be peripherally inserted central catheter occlusion. Two reviewers will independently screen the studies, based on the inclusion criteria, extract the data for each included study and assess the risk of bias using the Cochrane risk of bias tool. The data will be synthesized using the Review Manager software (RevMan 5.4.1). To classify the strength of the evidence of results, we will use the Grading of Recommendations Assessment, Development and Evaluation Working Group (GRADE). The review was registered with PROSPERO (registration number CRD42021281509).
We expect that this study would reveal the best method for preventing catheter occlusion in newborns with peripherally inserted central catheters.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0278068</identifier><identifier>PMID: 36584103</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Anticoagulants ; Bias ; Biology and Life Sciences ; Birth weight ; Catheterization ; Catheterization, Peripheral - adverse effects ; Catheters ; Chloride ; Chlorides ; Chlorine compounds ; Clinical medicine ; Clinical trials ; Complications ; Complications and side effects ; Engineering and Technology ; Evaluation ; Health aspects ; Health risks ; Heparin ; Heparin - therapeutic use ; Humans ; Infant, Newborn ; Infants (Premature) ; Intervention ; Literature reviews ; Mechanical properties ; Medical instruments ; Medical research ; Medicine and Health Sciences ; Medicine, Experimental ; Neonates ; Neonatology ; Newborn babies ; Occlusion ; Patient outcomes ; People and Places ; Performance evaluation ; Peripherally inserted central catheters ; Physical Sciences ; Premature babies ; Premature birth ; Quality ; Randomized Controlled Trials as Topic ; Research and Analysis Methods ; Risk assessment ; Sodium ; Sodium chloride ; Sodium Chloride - therapeutic use ; Software ; Study Protocol ; Systematic review ; Systematic Reviews as Topic ; Thrombosis ; Thrombosis - prevention & control ; Venous access ; Washing</subject><ispartof>PloS one, 2022-12, Vol.17 (12), p.e0278068</ispartof><rights>Copyright: © 2022 Nascimento et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Nascimento et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Nascimento et al 2022 Nascimento et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c641t-84700d4c0a151b4f846b2701b716bfb3789ea629595553f729e31f113a0c12483</cites><orcidid>0000-0001-7251-8966</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803159/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803159/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36584103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nascimento, Alice Passos do</creatorcontrib><creatorcontrib>de Medeiros, Kleyton Santos</creatorcontrib><creatorcontrib>Costa, Ana Paula Ferreira</creatorcontrib><creatorcontrib>Sarmento, Ayane Cristine</creatorcontrib><creatorcontrib>Cruz, Giovanna Karinny Pereira</creatorcontrib><creatorcontrib>Gonçalves, Ana Katherine</creatorcontrib><creatorcontrib>de Souza, Nilba Lima</creatorcontrib><creatorcontrib>Costa da Silva, Maria de Lourdes</creatorcontrib><title>Heparin versus 0.9% sodium chloride intermittent flushing for preventing occlusion in newborns with peripherally inserted central catheters: A systematic review protocol</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Mechanical factors are primary complications that justify early removal of a peripherally inserted central catheter, and thrombotic catheter occlusion is the most critical mechanical complication associated with loss of device functionality. Studies have investigated these factors in adult patients, but findings are not directly applicable to newborns. Therefore, systematic reviews focusing on this population are necessary for consolidated evidence to aid clinical practice.
This study aims to evaluate the efficacy of intermittent heparin washing versus 0.9% sodium chloride solution for preventing occlusion in newborns with peripherally inserted central catheters.
We will use the PubMed, Embase, Scopus, Web of Science, Cochrane Central Register of Controlled Trials, CINAHL, and Clinical Trial Databases for article search, without language or publication periods restrictions. Randomized clinical trials evaluating the use of intermittent heparin washing versus 0.9% sodium chloride solution in newborns with peripherally inserted central venous catheters will be included. The primary outcome will be peripherally inserted central catheter occlusion. Two reviewers will independently screen the studies, based on the inclusion criteria, extract the data for each included study and assess the risk of bias using the Cochrane risk of bias tool. The data will be synthesized using the Review Manager software (RevMan 5.4.1). To classify the strength of the evidence of results, we will use the Grading of Recommendations Assessment, Development and Evaluation Working Group (GRADE). The review was registered with PROSPERO (registration number CRD42021281509).
We expect that this study would reveal the best method for preventing catheter occlusion in newborns with peripherally inserted central catheters.</description><subject>Anticoagulants</subject><subject>Bias</subject><subject>Biology and Life Sciences</subject><subject>Birth weight</subject><subject>Catheterization</subject><subject>Catheterization, Peripheral - adverse effects</subject><subject>Catheters</subject><subject>Chloride</subject><subject>Chlorides</subject><subject>Chlorine compounds</subject><subject>Clinical medicine</subject><subject>Clinical trials</subject><subject>Complications</subject><subject>Complications and side effects</subject><subject>Engineering and Technology</subject><subject>Evaluation</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Heparin</subject><subject>Heparin - therapeutic use</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infants (Premature)</subject><subject>Intervention</subject><subject>Literature reviews</subject><subject>Mechanical properties</subject><subject>Medical instruments</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Medicine, Experimental</subject><subject>Neonates</subject><subject>Neonatology</subject><subject>Newborn babies</subject><subject>Occlusion</subject><subject>Patient outcomes</subject><subject>People and Places</subject><subject>Performance evaluation</subject><subject>Peripherally inserted central catheters</subject><subject>Physical Sciences</subject><subject>Premature babies</subject><subject>Premature birth</subject><subject>Quality</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Research and Analysis Methods</subject><subject>Risk assessment</subject><subject>Sodium</subject><subject>Sodium chloride</subject><subject>Sodium Chloride - therapeutic use</subject><subject>Software</subject><subject>Study Protocol</subject><subject>Systematic review</subject><subject>Systematic Reviews as Topic</subject><subject>Thrombosis</subject><subject>Thrombosis - prevention & control</subject><subject>Venous access</subject><subject>Washing</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk81u1DAQxyMEoqXwBggsIRAcdrHjJI45IFUV0JUqVeLrajnOeOPKiVPbadlH4i3xsmnVRT2gHBLP_OY_H_Fk2XOCl4Qy8v7CTX6Qdjm6AZY4ZzWu6gfZIeE0X1Q5pg_vfB9kT0K4wLikdVU9zg5oVdYFwfQw-30Ko_RmQFfgwxQQXvLXKLjWTD1SnXXetIDMEMH3JkYYItJ2Cp0Z1kg7j0YPV8m4PTqlkse4IeFogOvG-SGgaxM7NII3YwdeWrtJ3gA-QotUCkwmpGTsICUIH9AxCpsQoZfRKJSkDVynFC465ezT7JGWNsCz-X2U_fj86fvJ6eLs_Mvq5PhsoaqCxEVdMIzbQmFJStIUui6qJmeYNIxUjW4oqznIKuclL8uSapZzoEQTQiVWJC9qepS93OmO1gUxTzmInJW84pzWOBGrHdE6eSFGb3rpN8JJI_4anF8L6VMHFoRivAKodJmnQjDLa46hpYXGOVBd8CZpfZyzTU0P7TyTPdF9z2A6sXZXgqdCSMmTwNtZwLvLCUIUvQkKrJUDuGlXNy_rkrCEvvoHvb-7mVrL1IAZtEt51VZUHDNKWEGLmiRqeQ-VnhZ6o9KV1CbZ9wLe7QUkJsKvuJZTCGL17ev_s-c_99k3d9gOpI1dcHaK6SaGfbDYgcq7EDzo2yETLLYbdTMNsd0oMW9UCntx9wfdBt2sEP0DkOEeVw</recordid><startdate>20221230</startdate><enddate>20221230</enddate><creator>Nascimento, Alice Passos do</creator><creator>de Medeiros, Kleyton Santos</creator><creator>Costa, Ana Paula Ferreira</creator><creator>Sarmento, Ayane Cristine</creator><creator>Cruz, Giovanna Karinny Pereira</creator><creator>Gonçalves, Ana Katherine</creator><creator>de Souza, Nilba Lima</creator><creator>Costa da Silva, Maria de Lourdes</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-7251-8966</orcidid></search><sort><creationdate>20221230</creationdate><title>Heparin versus 0.9% sodium chloride intermittent flushing for preventing occlusion in newborns with peripherally inserted central catheters: A systematic review protocol</title><author>Nascimento, Alice Passos do ; de Medeiros, Kleyton Santos ; Costa, Ana Paula Ferreira ; Sarmento, Ayane Cristine ; Cruz, Giovanna Karinny Pereira ; Gonçalves, Ana Katherine ; de Souza, Nilba Lima ; Costa da Silva, Maria de Lourdes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c641t-84700d4c0a151b4f846b2701b716bfb3789ea629595553f729e31f113a0c12483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anticoagulants</topic><topic>Bias</topic><topic>Biology and Life Sciences</topic><topic>Birth weight</topic><topic>Catheterization</topic><topic>Catheterization, Peripheral - adverse effects</topic><topic>Catheters</topic><topic>Chloride</topic><topic>Chlorides</topic><topic>Chlorine compounds</topic><topic>Clinical medicine</topic><topic>Clinical trials</topic><topic>Complications</topic><topic>Complications and side effects</topic><topic>Engineering and Technology</topic><topic>Evaluation</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Heparin</topic><topic>Heparin - therapeutic use</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infants (Premature)</topic><topic>Intervention</topic><topic>Literature reviews</topic><topic>Mechanical properties</topic><topic>Medical instruments</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Medicine, Experimental</topic><topic>Neonates</topic><topic>Neonatology</topic><topic>Newborn babies</topic><topic>Occlusion</topic><topic>Patient outcomes</topic><topic>People and Places</topic><topic>Performance evaluation</topic><topic>Peripherally inserted central catheters</topic><topic>Physical Sciences</topic><topic>Premature babies</topic><topic>Premature birth</topic><topic>Quality</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Research and Analysis Methods</topic><topic>Risk assessment</topic><topic>Sodium</topic><topic>Sodium chloride</topic><topic>Sodium Chloride - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nascimento, Alice Passos do</au><au>de Medeiros, Kleyton Santos</au><au>Costa, Ana Paula Ferreira</au><au>Sarmento, Ayane Cristine</au><au>Cruz, Giovanna Karinny Pereira</au><au>Gonçalves, Ana Katherine</au><au>de Souza, Nilba Lima</au><au>Costa da Silva, Maria de Lourdes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heparin versus 0.9% sodium chloride intermittent flushing for preventing occlusion in newborns with peripherally inserted central catheters: A systematic review protocol</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2022-12-30</date><risdate>2022</risdate><volume>17</volume><issue>12</issue><spage>e0278068</spage><pages>e0278068-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Mechanical factors are primary complications that justify early removal of a peripherally inserted central catheter, and thrombotic catheter occlusion is the most critical mechanical complication associated with loss of device functionality. Studies have investigated these factors in adult patients, but findings are not directly applicable to newborns. Therefore, systematic reviews focusing on this population are necessary for consolidated evidence to aid clinical practice.
This study aims to evaluate the efficacy of intermittent heparin washing versus 0.9% sodium chloride solution for preventing occlusion in newborns with peripherally inserted central catheters.
We will use the PubMed, Embase, Scopus, Web of Science, Cochrane Central Register of Controlled Trials, CINAHL, and Clinical Trial Databases for article search, without language or publication periods restrictions. Randomized clinical trials evaluating the use of intermittent heparin washing versus 0.9% sodium chloride solution in newborns with peripherally inserted central venous catheters will be included. The primary outcome will be peripherally inserted central catheter occlusion. Two reviewers will independently screen the studies, based on the inclusion criteria, extract the data for each included study and assess the risk of bias using the Cochrane risk of bias tool. The data will be synthesized using the Review Manager software (RevMan 5.4.1). To classify the strength of the evidence of results, we will use the Grading of Recommendations Assessment, Development and Evaluation Working Group (GRADE). The review was registered with PROSPERO (registration number CRD42021281509).
We expect that this study would reveal the best method for preventing catheter occlusion in newborns with peripherally inserted central catheters.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>36584103</pmid><doi>10.1371/journal.pone.0278068</doi><tpages>e0278068</tpages><orcidid>https://orcid.org/0000-0001-7251-8966</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2759699380 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Anticoagulants Bias Biology and Life Sciences Birth weight Catheterization Catheterization, Peripheral - adverse effects Catheters Chloride Chlorides Chlorine compounds Clinical medicine Clinical trials Complications Complications and side effects Engineering and Technology Evaluation Health aspects Health risks Heparin Heparin - therapeutic use Humans Infant, Newborn Infants (Premature) Intervention Literature reviews Mechanical properties Medical instruments Medical research Medicine and Health Sciences Medicine, Experimental Neonates Neonatology Newborn babies Occlusion Patient outcomes People and Places Performance evaluation Peripherally inserted central catheters Physical Sciences Premature babies Premature birth Quality Randomized Controlled Trials as Topic Research and Analysis Methods Risk assessment Sodium Sodium chloride Sodium Chloride - therapeutic use Software Study Protocol Systematic review Systematic Reviews as Topic Thrombosis Thrombosis - prevention & control Venous access Washing |
| title | Heparin versus 0.9% sodium chloride intermittent flushing for preventing occlusion in newborns with peripherally inserted central catheters: A systematic review protocol |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T03%3A54%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Heparin%20versus%200.9%25%20sodium%20chloride%20intermittent%20flushing%20for%20preventing%20occlusion%20in%20newborns%20with%20peripherally%20inserted%20central%20catheters:%20A%20systematic%20review%20protocol&rft.jtitle=PloS%20one&rft.au=Nascimento,%20Alice%20Passos%20do&rft.date=2022-12-30&rft.volume=17&rft.issue=12&rft.spage=e0278068&rft.pages=e0278068-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0278068&rft_dat=%3Cgale_plos_%3EA731743481%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2759699380&rft_id=info:pmid/36584103&rft_galeid=A731743481&rft_doaj_id=oai_doaj_org_article_c796ee6f52f84072890ed34f02e3f49b&rfr_iscdi=true |