Quantitative evaluation of Mycobacterium abscessus clinical isolate virulence using a silkworm infection model

Mycobacterium abscessus causes chronic skin infections, lung diseases, and systemic or disseminated infections. Here we investigated whether the virulence of M. abscessus clinical isolates could be evaluated by calculating the median lethal dose (LD50) in a silkworm infection model. M. abscessus sub...

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Veröffentlicht in:	PloS one 2022-12, Vol.17 (12), p.e0278773-e0278773
Hauptverfasser:	Matsumoto, Yasuhiko, Fukano, Hanako, Hasegawa, Naoki, Hoshino, Yoshihiko, Sugita, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Antibacterial agents Antiinfectives and antibacterials Biology and Life Sciences Bombyx Care and treatment Chronic infection Clarithromycin Clarithromycin - pharmacology Clinical isolates Complications and side effects Drug dosages Experiments Hemolymph Humans Infections Infectious diseases Lethal dose Lung diseases Macrophages Medical research Medicine and Health Sciences Microbial Sensitivity Tests Microorganisms Modelling Mycobacteria Mycobacterium Mycobacterium abscessus Mycobacterium Infections, Nontuberculous - microbiology Pathogens Patient outcomes Physical Sciences Research and Analysis Methods Silkworms Skin diseases Statistical analysis Statistical significance Values Virulence
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