An amino-terminal fragment of apolipoprotein E4 leads to behavioral deficits, increased PHF-1 immunoreactivity, and mortality in zebrafish

Although the increased risk of developing sporadic Alzheimer's disease (AD) associated with the inheritance of the apolipoprotein E4 (APOE4) allele is well characterized, the molecular underpinnings of how ApoE4 imparts risk remains unknown. Enhanced proteolysis of the ApoE4 protein with a toxi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2022-12, Vol.17 (12), p.e0271707
Hauptverfasser:	McCarthy, Madyson M, Hardy, Makenna J, Leising, Saylor E, LaFollette, Alex M, Stewart, Erica S, Cogan, Amelia S, Sanghal, Tanya, Matteo, Katie, Reeck, Jonathon C, Oxford, Julia T, Rohn, Troy T
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Alzheimer Disease - metabolism Alzheimer's disease Alzheimers disease Amino acids Animals Apolipoprotein E3 - metabolism Apolipoprotein E4 Apolipoprotein E4 - metabolism Apolipoproteins Apolipoproteins E - metabolism Biocompatibility Biology and Life Sciences Complications and side effects Confocal microscopy Cortex (frontal) Danio rerio Diagnosis Embryos Experiments Fertilization Gene expression Genes Health aspects Health risks Heart rate Heredity Hindbrain Humans Immunoreactivity In vivo methods and tests Inflammation - metabolism Larvae Localization Medicine and Health Sciences Microglia - metabolism Microglial cells Morphology Mortality Mutation Neurodegeneration Neurodegenerative diseases Neurons - metabolism Pigmentation Polymorphism Proteins Proteolysis Research and Analysis Methods Risk analysis Risk factors Sublethal effects Tau protein Toxicity Yolk sac Zebra fish Zebrafish Zebrafish - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!