A deliberative public engagement study on heritable human genome editing among South Africans: Study results
This paper reports the results of a public engagement study on heritable human genome editing (HHGE) carried out in South Africa, which was conducted in accordance with a study protocol that was published in this journal in 2021. This study is novel as it is the first public engagement study on HHGE...
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| Veröffentlicht in: | PloS one 2022-11, Vol.17 (11), p.e0275372-e0275372 |
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| creator | Thaldar, Donrich Shozi, Bonginkosi Steytler, Michaela Hendry, Gill Botes, Marietjie Mnyandu, Ntokozo Naidoo, Meshandren Pillay, Siddharthiya Slabbert, Magda Townsend, Beverley |
| description | This paper reports the results of a public engagement study on heritable human genome editing (HHGE) carried out in South Africa, which was conducted in accordance with a study protocol that was published in this journal in 2021. This study is novel as it is the first public engagement study on HHGE in Africa. It used a deliberative public engagement (DPE) methodology, entailing inter alia that measures were put in place to ensure that potential participants became informed about HHGE, and that deliberations between the participants were facilitated with the aim of seeking consensus. A diverse group of 30 persons was selected to participate in the DPE study, which took place via Zoom over three consecutive weekday evenings. The main results are: Provided that HHGE is safe and effective, an overwhelming majority of participants supported allowing the use of HHGE to prevent genetic health conditions and for immunity against TB and HIV/Aids, while significant majorities opposed allowing HHGE for enhancement. The dominant paradigm during the deliberations was balancing health benefits (and associated improvements in quality of life) with unforeseen health risks (such as loss of natural immunity). The seriousness of a health condition emerged as the determining factor for the policy choice of whether to allow an application of HHGE. More generally, equal access to HHGE qua healthcare service featured as an important value, and it was uncontested that the South African government should allocate resources to promote scientific research into HHGE. These results are aligned with the policy principles for regulating HHGE in South Africa suggested by Thaldar et al. They call for urgent revision of South African ethics guidelines that currently prohibit research on HHGE, and for dedicated HHGE legal regulations that provide a clear and comprehensive legal pathway for researchers who intend to conduct HHGE research and clinical trials. |
| doi_str_mv | 10.1371/journal.pone.0275372 |
| format | Article |
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This study is novel as it is the first public engagement study on HHGE in Africa. It used a deliberative public engagement (DPE) methodology, entailing inter alia that measures were put in place to ensure that potential participants became informed about HHGE, and that deliberations between the participants were facilitated with the aim of seeking consensus. A diverse group of 30 persons was selected to participate in the DPE study, which took place via Zoom over three consecutive weekday evenings. The main results are: Provided that HHGE is safe and effective, an overwhelming majority of participants supported allowing the use of HHGE to prevent genetic health conditions and for immunity against TB and HIV/Aids, while significant majorities opposed allowing HHGE for enhancement. The dominant paradigm during the deliberations was balancing health benefits (and associated improvements in quality of life) with unforeseen health risks (such as loss of natural immunity). The seriousness of a health condition emerged as the determining factor for the policy choice of whether to allow an application of HHGE. More generally, equal access to HHGE qua healthcare service featured as an important value, and it was uncontested that the South African government should allocate resources to promote scientific research into HHGE. These results are aligned with the policy principles for regulating HHGE in South Africa suggested by Thaldar et al. They call for urgent revision of South African ethics guidelines that currently prohibit research on HHGE, and for dedicated HHGE legal regulations that provide a clear and comprehensive legal pathway for researchers who intend to conduct HHGE research and clinical trials.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0275372</identifier><identifier>PMID: 36441783</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Africans ; Analysis ; Biological diversity ; Biology and Life Sciences ; Black People - genetics ; Clinical trials ; Computer and Information Sciences ; CRISPR ; Editing ; Ethics ; Gene Editing ; Genes ; Genetic aspects ; Genome editing ; Genome, Human ; Genomes ; Health risks ; Health services ; HIV ; Human immunodeficiency virus ; Humans ; Immunity ; Medicine and Health Sciences ; People and places ; Public health ; Public opinion ; Public participation ; Quality of Life ; Scientific research ; South Africa ; Technology</subject><ispartof>PloS one, 2022-11, Vol.17 (11), p.e0275372-e0275372</ispartof><rights>Copyright: © 2022 Thaldar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Thaldar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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The seriousness of a health condition emerged as the determining factor for the policy choice of whether to allow an application of HHGE. More generally, equal access to HHGE qua healthcare service featured as an important value, and it was uncontested that the South African government should allocate resources to promote scientific research into HHGE. These results are aligned with the policy principles for regulating HHGE in South Africa suggested by Thaldar et al. They call for urgent revision of South African ethics guidelines that currently prohibit research on HHGE, and for dedicated HHGE legal regulations that provide a clear and comprehensive legal pathway for researchers who intend to conduct HHGE research and clinical trials.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>36441783</pmid><doi>10.1371/journal.pone.0275372</doi><tpages>e0275372</tpages><orcidid>https://orcid.org/0000-0003-2994-0795</orcidid><orcidid>https://orcid.org/0000-0002-8547-0380</orcidid><orcidid>https://orcid.org/0000-0002-7346-3490</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2022-11, Vol.17 (11), p.e0275372-e0275372 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Africans Analysis Biological diversity Biology and Life Sciences Black People - genetics Clinical trials Computer and Information Sciences CRISPR Editing Ethics Gene Editing Genes Genetic aspects Genome editing Genome, Human Genomes Health risks Health services HIV Human immunodeficiency virus Humans Immunity Medicine and Health Sciences People and places Public health Public opinion Public participation Quality of Life Scientific research South Africa Technology |
| title | A deliberative public engagement study on heritable human genome editing among South Africans: Study results |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T17%3A11%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20deliberative%20public%20engagement%20study%20on%20heritable%20human%20genome%20editing%20among%20South%20Africans:%20Study%20results&rft.jtitle=PloS%20one&rft.au=Thaldar,%20Donrich&rft.date=2022-11-28&rft.volume=17&rft.issue=11&rft.spage=e0275372&rft.epage=e0275372&rft.pages=e0275372-e0275372&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0275372&rft_dat=%3Cgale_plos_%3EA728146372%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2740840867&rft_id=info:pmid/36441783&rft_galeid=A728146372&rft_doaj_id=oai_doaj_org_article_c02daf2851b2486086ab48d3346db331&rfr_iscdi=true |