Interneurons of fan-shaped body promote arousal in Drosophila
Sleep is required to maintain physiological functions and is widely conserved across species. To understand the sleep-regulatory mechanisms, sleep-regulating genes and neuronal circuits are studied in various animal species. In the sleep-regulatory neuronal circuits in Drosophila melanogaster, the d...
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| creator | Kato, Yoshiaki S Tomita, Jun Kume, Kazuhiko |
| description | Sleep is required to maintain physiological functions and is widely conserved across species. To understand the sleep-regulatory mechanisms, sleep-regulating genes and neuronal circuits are studied in various animal species. In the sleep-regulatory neuronal circuits in Drosophila melanogaster, the dorsal fan-shaped body (dFB) is a major sleep-promoting region. However, other sleep-regulating neuronal circuits were not well identified. We recently found that arousal-promoting T1 dopamine neurons, interneurons of protocerebral bridge (PB) neurons, and PB neurons innervating the ventral part of the FB form a sleep-regulatory circuit, which we named "the PB-FB pathway". In the exploration of other sleep-regulatory circuits, we found that activation of FB interneurons, also known as pontine neurons, promoted arousal. We then found that FB interneurons had possible connections with the PB-FB pathway and dFB neurons. Ca2+ imaging revealed that FB interneurons received excitatory signals from the PB-FB pathway. We also demonstrated the possible role of FB interneurons to regulate dFB neurons. These results suggested the role of FB interneurons in sleep regulation. |
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C.</contributor><creatorcontrib>Kato, Yoshiaki S ; Tomita, Jun ; Kume, Kazuhiko ; Skoulakis, Efthimios M. C.</creatorcontrib><description>Sleep is required to maintain physiological functions and is widely conserved across species. To understand the sleep-regulatory mechanisms, sleep-regulating genes and neuronal circuits are studied in various animal species. In the sleep-regulatory neuronal circuits in Drosophila melanogaster, the dorsal fan-shaped body (dFB) is a major sleep-promoting region. However, other sleep-regulating neuronal circuits were not well identified. We recently found that arousal-promoting T1 dopamine neurons, interneurons of protocerebral bridge (PB) neurons, and PB neurons innervating the ventral part of the FB form a sleep-regulatory circuit, which we named "the PB-FB pathway". In the exploration of other sleep-regulatory circuits, we found that activation of FB interneurons, also known as pontine neurons, promoted arousal. We then found that FB interneurons had possible connections with the PB-FB pathway and dFB neurons. Ca2+ imaging revealed that FB interneurons received excitatory signals from the PB-FB pathway. We also demonstrated the possible role of FB interneurons to regulate dFB neurons. These results suggested the role of FB interneurons in sleep regulation.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0277918</identifier><identifier>PMID: 36409701</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Animal species ; Animals ; Arousal ; Arousal - physiology ; Biology and Life Sciences ; Calcium imaging ; Calcium ions ; Circuits ; Control ; Dopamine ; Dopaminergic Neurons - metabolism ; Drosophila ; Drosophila - metabolism ; Drosophila melanogaster - metabolism ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Fruit flies ; Identification and classification ; Insects ; Interneurons ; Interneurons - metabolism ; Mammals ; Medicine and Health Sciences ; Neurons ; Physical Sciences ; Prevention ; Regulation ; Regulatory mechanisms (biology) ; Research and Analysis Methods ; Risk factors ; Sleep ; Sleep disorders</subject><ispartof>PloS one, 2022-11, Vol.17 (11), p.e0277918-e0277918</ispartof><rights>Copyright: © 2022 Kato et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Kato et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Kato et al 2022 Kato et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c688t-94c3d210d2bbd81b8c1548972f7da6d17f77ca9e3264903bd7592fd10cfa77133</citedby><cites>FETCH-LOGICAL-c688t-94c3d210d2bbd81b8c1548972f7da6d17f77ca9e3264903bd7592fd10cfa77133</cites><orcidid>0000-0003-4232-1657</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678257/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678257/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23865,27923,27924,53790,53792,79371,79372</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36409701$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Skoulakis, Efthimios M. 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In the exploration of other sleep-regulatory circuits, we found that activation of FB interneurons, also known as pontine neurons, promoted arousal. We then found that FB interneurons had possible connections with the PB-FB pathway and dFB neurons. Ca2+ imaging revealed that FB interneurons received excitatory signals from the PB-FB pathway. We also demonstrated the possible role of FB interneurons to regulate dFB neurons. These results suggested the role of FB interneurons in sleep regulation.</description><subject>Analysis</subject><subject>Animal species</subject><subject>Animals</subject><subject>Arousal</subject><subject>Arousal - physiology</subject><subject>Biology and Life Sciences</subject><subject>Calcium imaging</subject><subject>Calcium ions</subject><subject>Circuits</subject><subject>Control</subject><subject>Dopamine</subject><subject>Dopaminergic Neurons - metabolism</subject><subject>Drosophila</subject><subject>Drosophila - metabolism</subject><subject>Drosophila melanogaster - metabolism</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - metabolism</subject><subject>Fruit flies</subject><subject>Identification and classification</subject><subject>Insects</subject><subject>Interneurons</subject><subject>Interneurons - metabolism</subject><subject>Mammals</subject><subject>Medicine and Health Sciences</subject><subject>Neurons</subject><subject>Physical Sciences</subject><subject>Prevention</subject><subject>Regulation</subject><subject>Regulatory mechanisms (biology)</subject><subject>Research and Analysis Methods</subject><subject>Risk factors</subject><subject>Sleep</subject><subject>Sleep disorders</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkltrFDEYhgdRbF39B6IDgujFrjlNDhcKpZ4WCgVPtyGTw25KdjImM2L_vVl3WnakF5KLhOR53-T78lbVUwhWEDP45iqOqVNh1cfOrgBiTEB-rzqFAqMlRQDfP1qfVI9yvgKgwZzSh9UJpgQIBuBp9XbdDTZ1dkyxy3V0tVPdMm9Vb03dRnNd9ynu4mBrleKYVah9V79PMcd-64N6XD1wKmT7ZJoX1fePH76df15eXH5an59dLDXlfFgKorFBEBjUtobDlmvYEC4YcswoaiBzjGklLEaUCIBbwxqBnIFAO8UYxHhRPT_49iFmOVWeJWKYE8Bh0Syq9YEwUV3JPvmdStcyKi__bsS0kSoNXgcrUeMooEY3xCjSEsK1oBxwqoWx1sG2eL2bbhvbnTXadkNSYWY6P-n8Vm7iLyko46hhxeDVZJDiz9HmQe581jYE1dnSxcO7OScCFfTFP-jd1U3URpUCfOdiuVfvTeUZQ4xQyPCeWt1BlWHszusSE-fL_kzweiYozGB_Dxs15izXX7_8P3v5Y86-PGK3VoVhm2MYB19CNgfJAdQlUjlZd9tkCOQ-5TfdkPuUyynlRfbs-INuRTexxn8ApRn2Pw</recordid><startdate>20221121</startdate><enddate>20221121</enddate><creator>Kato, Yoshiaki S</creator><creator>Tomita, Jun</creator><creator>Kume, Kazuhiko</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4232-1657</orcidid></search><sort><creationdate>20221121</creationdate><title>Interneurons of fan-shaped body promote arousal in Drosophila</title><author>Kato, Yoshiaki S ; Tomita, Jun ; Kume, Kazuhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c688t-94c3d210d2bbd81b8c1548972f7da6d17f77ca9e3264903bd7592fd10cfa77133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Analysis</topic><topic>Animal species</topic><topic>Animals</topic><topic>Arousal</topic><topic>Arousal - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kato, Yoshiaki S</au><au>Tomita, Jun</au><au>Kume, Kazuhiko</au><au>Skoulakis, Efthimios M. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interneurons of fan-shaped body promote arousal in Drosophila</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2022-11-21</date><risdate>2022</risdate><volume>17</volume><issue>11</issue><spage>e0277918</spage><epage>e0277918</epage><pages>e0277918-e0277918</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Sleep is required to maintain physiological functions and is widely conserved across species. To understand the sleep-regulatory mechanisms, sleep-regulating genes and neuronal circuits are studied in various animal species. In the sleep-regulatory neuronal circuits in Drosophila melanogaster, the dorsal fan-shaped body (dFB) is a major sleep-promoting region. However, other sleep-regulating neuronal circuits were not well identified. We recently found that arousal-promoting T1 dopamine neurons, interneurons of protocerebral bridge (PB) neurons, and PB neurons innervating the ventral part of the FB form a sleep-regulatory circuit, which we named "the PB-FB pathway". In the exploration of other sleep-regulatory circuits, we found that activation of FB interneurons, also known as pontine neurons, promoted arousal. We then found that FB interneurons had possible connections with the PB-FB pathway and dFB neurons. Ca2+ imaging revealed that FB interneurons received excitatory signals from the PB-FB pathway. We also demonstrated the possible role of FB interneurons to regulate dFB neurons. These results suggested the role of FB interneurons in sleep regulation.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>36409701</pmid><doi>10.1371/journal.pone.0277918</doi><tpages>e0277918</tpages><orcidid>https://orcid.org/0000-0003-4232-1657</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Animal species Animals Arousal Arousal - physiology Biology and Life Sciences Calcium imaging Calcium ions Circuits Control Dopamine Dopaminergic Neurons - metabolism Drosophila Drosophila - metabolism Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Fruit flies Identification and classification Insects Interneurons Interneurons - metabolism Mammals Medicine and Health Sciences Neurons Physical Sciences Prevention Regulation Regulatory mechanisms (biology) Research and Analysis Methods Risk factors Sleep Sleep disorders |
| title | Interneurons of fan-shaped body promote arousal in Drosophila |
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