DPCfam: Unsupervised protein family classification by Density Peak Clustering of large sequence datasets

Proteins that are known only at a sequence level outnumber those with an experimental characterization by orders of magnitude. Classifying protein regions (domains) into homologous families can generate testable functional hypotheses for yet unannotated sequences. Existing domain family resources ty...

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Veröffentlicht in:PLoS computational biology 2022-10, Vol.18 (10), p.e1010610
Hauptverfasser: Russo, Elena Tea, Barone, Federico, Bateman, Alex, Cozzini, Stefano, Punta, Marco, Laio, Alessandro
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Sprache:eng
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