Distinct phosphorylation states of mammalian CaMKIIβ control the induction and maintenance of sleep

The reduced sleep duration previously observed in Camk2b knockout mice revealed a role for Ca 2+ /calmodulin-dependent protein kinase II (CaMKII)β as a sleep-promoting kinase. However, the underlying mechanism by which CaMKIIβ supports sleep regulation is largely unknown. Here, we demonstrate that a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS biology 2022-10, Vol.20 (10), p.e3001813-e3001813
Hauptverfasser:	Tone, Daisuke, Ode, Koji L., Zhang, Qianhui, Fujishima, Hiroshi, Yamada, Rikuhiro G., Nagashima, Yoshiki, Matsumoto, Katsuhiko, Wen, Zhiqing, Yoshida, Shota Y., Mitani, Tomoki T., Arisato, Yuki, Ohno, Rei-ichiro, Ukai-Tadenuma, Maki, Yoshida Garçon, Junko, Kaneko, Mari, Shi, Shoi, Ukai, Hideki, Miyamichi, Kazunari, Okada, Takashi, Sumiyama, Kenta, Kiyonari, Hiroshi, Ueda, Hiroki R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and Life Sciences Ca2+/calmodulin-dependent protein kinase II Calcium ions Calcium-binding protein Calmodulin Efficiency Gene expression Hypotheses Kinases Maintenance Mammals Medicine and Health Sciences Mimicry Mutants Phosphorylation Physiology Proteins Research and Analysis Methods Sleep
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!