Nascent polypeptide-Associated Complex and Signal Recognition Particle have cardiac-specific roles in heart development and remodeling

Establishing a catalog of Congenital Heart Disease (CHD) genes and identifying functional networks would improve our understanding of its oligogenic underpinnings. Our studies identified protein biogenesis cofactors Nascent polypeptide-Associated Complex (NAC) and Signal-Recognition-Particle (SRP) a...

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Veröffentlicht in:	PLoS genetics 2022-10, Vol.18 (10), p.e1010448-e1010448
Hauptverfasser:	Schroeder, Analyne M, Nielsen, Tanja, Lynott, Michaela, Vogler, Georg, Colas, Alexandre R, Bodmer, Rolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Animals Biology and Life Sciences Biosynthesis Cell differentiation Cofactors Coronary vessels Drosophila - genetics Drosophila - metabolism Embryos Gene expression Genes, Homeobox Genetic aspects Genetic research Genomics Genotype & phenotype Growth Heart Heart cells Heart diseases HOX gene Humans Insects Localization Medicine and Health Sciences Metamorphosis Morphogenesis Pathogenesis Patients Pattern formation Peptides - metabolism Phenotypes Polypeptides Progenitor cells Properties Proteins Research and Analysis Methods Ribosomes - metabolism Signal recognition particle Signal Recognition Particle - metabolism Transcription factors
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