Progression of microstructural deterioration in load-bearing immobilization osteopenia

Immobilization osteopenia is a major healthcare problem in clinical and social medicine. However, the mechanisms underlying this bone pathology caused by immobilization under load-bearing conditions are not yet fully understood. This study aimed to evaluate sequential changes to the three-dimensiona...

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Veröffentlicht in:	PloS one 2022-11, Vol.17 (11), p.e0275439-e0275439
Hauptverfasser:	Koseki, Hironobu, Osaki, Makoto, Honda, Yuichiro, Sunagawa, Shinya, Imai, Chieko, Shida, Takayuki, Matsumura, Umi, Sakamoto, Junya, Tomonaga, Iku, Yokoo, Seiichi, Mizukami, Satoshi, Okita, Minoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Biology and Life Sciences Bone (cancellous) Bone (cortical) Bone Density Bone Diseases, Metabolic - pathology Botulinum toxin Cancellous bone Care and treatment Computed tomography Cortical bone Development and progression Femur Fixation Fracture fixation Fractures Immobilization Immobilization - adverse effects Male Medicine and Health Sciences Metabolism Methods Microstructure Moments of inertia Muscle contraction Orthopedics Osteopenia Osteoporosis Parameters Patient outcomes Physical Sciences Rats Rats, Wistar Rodents Social medicine Specific pathogen free Spinal cord Weight-Bearing X-Ray Microtomography - adverse effects
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