Early life events in functional abdominal pain disorders in children
Objectives Functional abdominal pain disorders (FAPDs) are common gastrointestinal problems in children, and the pathophysiology is thought to be multifactorial. Adverse early life events (ELE) induce alterations in the central nervous system, perhaps predisposing individuals to develop FAPDs. We ai...
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| description | Objectives Functional abdominal pain disorders (FAPDs) are common gastrointestinal problems in children, and the pathophysiology is thought to be multifactorial. Adverse early life events (ELE) induce alterations in the central nervous system, perhaps predisposing individuals to develop FAPDs. We aimed to study the potential adverse ELE that are associated with FAPDs. Methods We steered a school-based survey involving 1000 children from 4 randomly selected schools. FAPDs were assessed using the translated Rome III questionnaire, and ELE were identified using a pre-tested, parental questionnaire. FAPDs were diagnosed using the Rome III criteria. Results Hundred and eighty-two (182) children had FAPDs (62.1% girls, mean age 8.5, SD 2.1). ELE of them were compared with 571 children without FAPDs (51.1% girls, mean age 8.8, SD 1.9). According to the binary logistic regression analysis, family members with abdominal pain, family member with chronic pain other than abdominal pain, prenatal maternal complications and interventional deliveries, were recognized as potential risk factors for the development of FAPDs. Breast feeding over two years has shown to reduce the prevalence of FAPDs.a. Conclusions Prenatal maternal medical problems are associated a with higher prevalence of FAPDs later in life. Prolonged breastfeeding and normal vaginal delivery could be considered as factors that reduce the vulnerability of developing FAPDs in children. Therefore, minimizing pregnancy-related complications, encouraging vaginal deliveries, and encouraging breastfeeding are potentially valuable measures to prevent FAPDs during childhood. |
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Adverse early life events (ELE) induce alterations in the central nervous system, perhaps predisposing individuals to develop FAPDs. We aimed to study the potential adverse ELE that are associated with FAPDs. Methods We steered a school-based survey involving 1000 children from 4 randomly selected schools. FAPDs were assessed using the translated Rome III questionnaire, and ELE were identified using a pre-tested, parental questionnaire. FAPDs were diagnosed using the Rome III criteria. Results Hundred and eighty-two (182) children had FAPDs (62.1% girls, mean age 8.5, SD 2.1). ELE of them were compared with 571 children without FAPDs (51.1% girls, mean age 8.8, SD 1.9). According to the binary logistic regression analysis, family members with abdominal pain, family member with chronic pain other than abdominal pain, prenatal maternal complications and interventional deliveries, were recognized as potential risk factors for the development of FAPDs. Breast feeding over two years has shown to reduce the prevalence of FAPDs.a. Conclusions Prenatal maternal medical problems are associated a with higher prevalence of FAPDs later in life. Prolonged breastfeeding and normal vaginal delivery could be considered as factors that reduce the vulnerability of developing FAPDs in children. Therefore, minimizing pregnancy-related complications, encouraging vaginal deliveries, and encouraging breastfeeding are potentially valuable measures to prevent FAPDs during childhood.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0275419</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Abdomen ; Abdominal pain in children ; Breast feeding ; Breastfeeding & lactation ; Care and treatment ; Central nervous system ; Children ; Chronic pain ; Complications ; Data collection ; Diagnosis ; Disorders ; Education ; Families & family life ; Gastrointestinal diseases ; Health aspects ; Health risks ; Hypnotherapy ; Irritable bowel syndrome ; Methods ; Newborn babies ; Pain ; Parents & parenting ; Pediatrics ; Physiology, Pathological ; Postpartum period ; Pregnancy complications ; Pregnancy, Complications of ; Prevention ; Quality of life ; Questionnaires ; Regression analysis ; Risk analysis ; Risk factors ; Schools ; Vagina</subject><ispartof>PloS one, 2022-11, Vol.17 (11), p.e0275419-e0275419</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Karunanayake et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Karunanayake et al 2022 Karunanayake et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c669t-50eb3217491f80da47536e50cfa0d8214a691828f9447f0fd42b8f8ba36e1d993</citedby><cites>FETCH-LOGICAL-c669t-50eb3217491f80da47536e50cfa0d8214a691828f9447f0fd42b8f8ba36e1d993</cites><orcidid>0000-0001-5836-6329</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629606/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629606/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids></links><search><contributor>Hu, Zhen Hua</contributor><creatorcontrib>Karunanayake, Amaranath</creatorcontrib><creatorcontrib>Devanarayana, Niranga Manjuri</creatorcontrib><creatorcontrib>Rajindrajith, Shaman</creatorcontrib><title>Early life events in functional abdominal pain disorders in children</title><title>PloS one</title><description>Objectives Functional abdominal pain disorders (FAPDs) are common gastrointestinal problems in children, and the pathophysiology is thought to be multifactorial. Adverse early life events (ELE) induce alterations in the central nervous system, perhaps predisposing individuals to develop FAPDs. We aimed to study the potential adverse ELE that are associated with FAPDs. Methods We steered a school-based survey involving 1000 children from 4 randomly selected schools. FAPDs were assessed using the translated Rome III questionnaire, and ELE were identified using a pre-tested, parental questionnaire. FAPDs were diagnosed using the Rome III criteria. Results Hundred and eighty-two (182) children had FAPDs (62.1% girls, mean age 8.5, SD 2.1). ELE of them were compared with 571 children without FAPDs (51.1% girls, mean age 8.8, SD 1.9). According to the binary logistic regression analysis, family members with abdominal pain, family member with chronic pain other than abdominal pain, prenatal maternal complications and interventional deliveries, were recognized as potential risk factors for the development of FAPDs. Breast feeding over two years has shown to reduce the prevalence of FAPDs.a. Conclusions Prenatal maternal medical problems are associated a with higher prevalence of FAPDs later in life. Prolonged breastfeeding and normal vaginal delivery could be considered as factors that reduce the vulnerability of developing FAPDs in children. Therefore, minimizing pregnancy-related complications, encouraging vaginal deliveries, and encouraging breastfeeding are potentially valuable measures to prevent FAPDs during childhood.</description><subject>Abdomen</subject><subject>Abdominal pain in children</subject><subject>Breast feeding</subject><subject>Breastfeeding & lactation</subject><subject>Care and treatment</subject><subject>Central nervous system</subject><subject>Children</subject><subject>Chronic pain</subject><subject>Complications</subject><subject>Data collection</subject><subject>Diagnosis</subject><subject>Disorders</subject><subject>Education</subject><subject>Families & family life</subject><subject>Gastrointestinal diseases</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Hypnotherapy</subject><subject>Irritable bowel syndrome</subject><subject>Methods</subject><subject>Newborn babies</subject><subject>Pain</subject><subject>Parents & parenting</subject><subject>Pediatrics</subject><subject>Physiology, Pathological</subject><subject>Postpartum period</subject><subject>Pregnancy complications</subject><subject>Pregnancy, Complications of</subject><subject>Prevention</subject><subject>Quality of life</subject><subject>Questionnaires</subject><subject>Regression analysis</subject><subject>Risk analysis</subject><subject>Risk 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life events in functional abdominal pain disorders in children</title><author>Karunanayake, Amaranath ; Devanarayana, Niranga Manjuri ; Rajindrajith, Shaman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c669t-50eb3217491f80da47536e50cfa0d8214a691828f9447f0fd42b8f8ba36e1d993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Abdomen</topic><topic>Abdominal pain in children</topic><topic>Breast feeding</topic><topic>Breastfeeding & lactation</topic><topic>Care and treatment</topic><topic>Central nervous system</topic><topic>Children</topic><topic>Chronic pain</topic><topic>Complications</topic><topic>Data collection</topic><topic>Diagnosis</topic><topic>Disorders</topic><topic>Education</topic><topic>Families & family life</topic><topic>Gastrointestinal diseases</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Hypnotherapy</topic><topic>Irritable bowel 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karunanayake, Amaranath</au><au>Devanarayana, Niranga Manjuri</au><au>Rajindrajith, Shaman</au><au>Hu, Zhen Hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early life events in functional abdominal pain disorders in children</atitle><jtitle>PloS one</jtitle><date>2022-11-02</date><risdate>2022</risdate><volume>17</volume><issue>11</issue><spage>e0275419</spage><epage>e0275419</epage><pages>e0275419-e0275419</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Objectives Functional abdominal pain disorders (FAPDs) are common gastrointestinal problems in children, and the pathophysiology is thought to be multifactorial. Adverse early life events (ELE) induce alterations in the central nervous system, perhaps predisposing individuals to develop FAPDs. We aimed to study the potential adverse ELE that are associated with FAPDs. Methods We steered a school-based survey involving 1000 children from 4 randomly selected schools. FAPDs were assessed using the translated Rome III questionnaire, and ELE were identified using a pre-tested, parental questionnaire. FAPDs were diagnosed using the Rome III criteria. Results Hundred and eighty-two (182) children had FAPDs (62.1% girls, mean age 8.5, SD 2.1). ELE of them were compared with 571 children without FAPDs (51.1% girls, mean age 8.8, SD 1.9). According to the binary logistic regression analysis, family members with abdominal pain, family member with chronic pain other than abdominal pain, prenatal maternal complications and interventional deliveries, were recognized as potential risk factors for the development of FAPDs. Breast feeding over two years has shown to reduce the prevalence of FAPDs.a. Conclusions Prenatal maternal medical problems are associated a with higher prevalence of FAPDs later in life. Prolonged breastfeeding and normal vaginal delivery could be considered as factors that reduce the vulnerability of developing FAPDs in children. Therefore, minimizing pregnancy-related complications, encouraging vaginal deliveries, and encouraging breastfeeding are potentially valuable measures to prevent FAPDs during childhood.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><doi>10.1371/journal.pone.0275419</doi><tpages>e0275419</tpages><orcidid>https://orcid.org/0000-0001-5836-6329</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Abdomen Abdominal pain in children Breast feeding Breastfeeding & lactation Care and treatment Central nervous system Children Chronic pain Complications Data collection Diagnosis Disorders Education Families & family life Gastrointestinal diseases Health aspects Health risks Hypnotherapy Irritable bowel syndrome Methods Newborn babies Pain Parents & parenting Pediatrics Physiology, Pathological Postpartum period Pregnancy complications Pregnancy, Complications of Prevention Quality of life Questionnaires Regression analysis Risk analysis Risk factors Schools Vagina |
| title | Early life events in functional abdominal pain disorders in children |
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