HSV-1 and influenza infection induce linear and circular splicing of the long NEAT1 isoform

The herpes simplex virus 1 (HSV-1) virion host shut-off (vhs) protein cleaves both cellular and viral mRNAs by a translation-initiation-dependent mechanism, which should spare circular RNAs (circRNAs). Here, we show that vhs-mediated degradation of linear mRNAs leads to an enrichment of circRNAs rel...

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Veröffentlicht in:	PloS one 2022-10, Vol.17 (10), p.e0276467-e0276467
Hauptverfasser:	Friedl, Marie-Sophie, Djakovic, Lara, Kluge, Michael, Hennig, Thomas, Whisnant, Adam W, Backes, Simone, Dölken, Lars, Friedel, Caroline C
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Alternative splicing Analysis Assembly Biology and life sciences Biosynthesis Complications and side effects Cyclin-dependent kinases Degradation Diagnosis DNA-directed RNA polymerase Gene expression Genetic translation Herpes simplex Herpes simplex virus Herpes viruses Immediate-early proteins Infection Infections Influenza Influenza A Isoforms Kinases Medicine and health sciences Phosphorylation Proteins Research and Analysis Methods Risk factors RNA polymerase RNA-directed RNA polymerase Translation initiation Viral infections Virions Viruses
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