Diagnostic performances of pepsinogens and gastrin-17 for atrophic gastritis and gastric cancer in Mongolian subjects
In Mongolia, gastric cancer morbidity and mortality are high, and more than 80 percent of cases are diagnosed at an advanced stage. This study aimed to evaluate pepsinogens (PGIs) and gastrin-17 (G-17) levels and to determine the diagnostic performances for gastric cancer and chronic atrophic gastri...
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| creator | Dondov, Ganchimeg Amarbayasgalan, Dashmaa Batsaikhan, Batbold Badamjav, Tegshjargal Batbaatar, Batchimeg Tuvdenjamts, Baljinnyam Tumurbat, Nasanjargal Davaa, Bayar Purevdorj, Erkhembulgan Nyamaa, Bayarmaa Lonjid, Tulgaa |
| description | In Mongolia, gastric cancer morbidity and mortality are high, and more than 80 percent of cases are diagnosed at an advanced stage. This study aimed to evaluate pepsinogens (PGIs) and gastrin-17 (G-17) levels and to determine the diagnostic performances for gastric cancer and chronic atrophic gastritis among Mongolian individuals. We enrolled a total of 120 subjects, including gastric cancer (40), atrophic gastritis (40), and healthy control (40), matched by age (±2) and sex. Pepsinogen I (PGI), Pepsinogen II (PGII), G-17, and H. pylori IgG levels were measured using GastroPanel ELISA kit (Biohit, Helsinki, Finland). Also, PGI to PGII ratio (PGR) was calculated. For atrophic gastritis, when the optimal cut-off value of PGI was [less than or equal to]75.07 ng/ml, the sensitivity and specificity were 75% and 50%, respectively; when the optimal cut-off value of PGR was [less than or equal to]6.25, sensitivity and specificity were 85% and 44.7%, respectively. For gastric cancer, when the optimal cut-off value of PGI was [less than or equal to]35.25 ng/ml, the sensitivity and specificity were 47.2% and 86.8%, respectively; when the optimal cut-off value of PGR was [less than or equal to]5.27, sensitivity and specificity were 75% and 60.5%, respectively. Combinations of biomarkers with risk factors could improve diagnostic accuracy (AUC for atrophic gastritis 74.8, 95% CI 64.0-85.7, p |
| doi_str_mv | 10.1371/journal.pone.0274938 |
| format | Article |
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This study aimed to evaluate pepsinogens (PGIs) and gastrin-17 (G-17) levels and to determine the diagnostic performances for gastric cancer and chronic atrophic gastritis among Mongolian individuals. We enrolled a total of 120 subjects, including gastric cancer (40), atrophic gastritis (40), and healthy control (40), matched by age (±2) and sex. Pepsinogen I (PGI), Pepsinogen II (PGII), G-17, and H. pylori IgG levels were measured using GastroPanel ELISA kit (Biohit, Helsinki, Finland). Also, PGI to PGII ratio (PGR) was calculated. For atrophic gastritis, when the optimal cut-off value of PGI was [less than or equal to]75.07 ng/ml, the sensitivity and specificity were 75% and 50%, respectively; when the optimal cut-off value of PGR was [less than or equal to]6.25, sensitivity and specificity were 85% and 44.7%, respectively. For gastric cancer, when the optimal cut-off value of PGI was [less than or equal to]35.25 ng/ml, the sensitivity and specificity were 47.2% and 86.8%, respectively; when the optimal cut-off value of PGR was [less than or equal to]5.27, sensitivity and specificity were 75% and 60.5%, respectively. Combinations of biomarkers with risk factors could improve diagnostic accuracy (AUC for atrophic gastritis 74.8, 95% CI 64.0-85.7, p<0.001; AUC for gastric cancer 75.5, 95% CI 64.2-86.8, p<0.001). PGI, PGR biomarkers combined with the risk of age, family history of gastric cancer, and previous gastric disease could not be an alternative test for upper endoscopy but might be a supportive method which is identifying individuals at medium- and high risk of gastric cancer and precancerous lesions who may need upper endoscopy.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0274938</identifier><identifier>PMID: 36251649</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Biology and Life Sciences ; Biomarkers ; Biopsy ; Cancer ; Diagnosis ; Diagnostic systems ; Disease ; Endoscopy ; Family medical history ; Gastric cancer ; Gastrin ; Gastritis ; Genetic aspects ; Genetics ; Health aspects ; Health risks ; Immunoglobulin G ; Medical diagnosis ; Medicine and Health Sciences ; Morbidity ; Mortality ; Risk analysis ; Risk factors ; Sensitivity ; Stomach cancer</subject><ispartof>PloS one, 2022-10, Vol.17 (10), p.e0274938-e0274938</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Dondov et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Dondov et al 2022 Dondov et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c599t-e79f5124f968d7cc9c077d05db0b720f83e4b7c2bd0841b71f00528d647fae823</citedby><cites>FETCH-LOGICAL-c599t-e79f5124f968d7cc9c077d05db0b720f83e4b7c2bd0841b71f00528d647fae823</cites><orcidid>0000-0002-2565-0347</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576095/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576095/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2101,2927,23865,27923,27924,53790,53792,79471,79472</link.rule.ids></links><search><contributor>Abdel Ghafar, Muhammad Tarek</contributor><creatorcontrib>Dondov, Ganchimeg</creatorcontrib><creatorcontrib>Amarbayasgalan, Dashmaa</creatorcontrib><creatorcontrib>Batsaikhan, Batbold</creatorcontrib><creatorcontrib>Badamjav, Tegshjargal</creatorcontrib><creatorcontrib>Batbaatar, Batchimeg</creatorcontrib><creatorcontrib>Tuvdenjamts, Baljinnyam</creatorcontrib><creatorcontrib>Tumurbat, Nasanjargal</creatorcontrib><creatorcontrib>Davaa, Bayar</creatorcontrib><creatorcontrib>Purevdorj, Erkhembulgan</creatorcontrib><creatorcontrib>Nyamaa, Bayarmaa</creatorcontrib><creatorcontrib>Lonjid, Tulgaa</creatorcontrib><title>Diagnostic performances of pepsinogens and gastrin-17 for atrophic gastritis and gastric cancer in Mongolian subjects</title><title>PloS one</title><description>In Mongolia, gastric cancer morbidity and mortality are high, and more than 80 percent of cases are diagnosed at an advanced stage. This study aimed to evaluate pepsinogens (PGIs) and gastrin-17 (G-17) levels and to determine the diagnostic performances for gastric cancer and chronic atrophic gastritis among Mongolian individuals. We enrolled a total of 120 subjects, including gastric cancer (40), atrophic gastritis (40), and healthy control (40), matched by age (±2) and sex. Pepsinogen I (PGI), Pepsinogen II (PGII), G-17, and H. pylori IgG levels were measured using GastroPanel ELISA kit (Biohit, Helsinki, Finland). Also, PGI to PGII ratio (PGR) was calculated. For atrophic gastritis, when the optimal cut-off value of PGI was [less than or equal to]75.07 ng/ml, the sensitivity and specificity were 75% and 50%, respectively; when the optimal cut-off value of PGR was [less than or equal to]6.25, sensitivity and specificity were 85% and 44.7%, respectively. 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PGI, PGR biomarkers combined with the risk of age, family history of gastric cancer, and previous gastric disease could not be an alternative test for upper endoscopy but might be a supportive method which is identifying individuals at medium- and high risk of gastric cancer and precancerous lesions who may need upper endoscopy.</description><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Biopsy</subject><subject>Cancer</subject><subject>Diagnosis</subject><subject>Diagnostic systems</subject><subject>Disease</subject><subject>Endoscopy</subject><subject>Family medical history</subject><subject>Gastric cancer</subject><subject>Gastrin</subject><subject>Gastritis</subject><subject>Genetic aspects</subject><subject>Genetics</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Immunoglobulin G</subject><subject>Medical diagnosis</subject><subject>Medicine and Health 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performances of pepsinogens and gastrin-17 for atrophic gastritis and gastric cancer in Mongolian subjects</title><author>Dondov, Ganchimeg ; Amarbayasgalan, Dashmaa ; Batsaikhan, Batbold ; Badamjav, Tegshjargal ; Batbaatar, Batchimeg ; Tuvdenjamts, Baljinnyam ; Tumurbat, Nasanjargal ; Davaa, Bayar ; Purevdorj, Erkhembulgan ; Nyamaa, Bayarmaa ; Lonjid, Tulgaa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c599t-e79f5124f968d7cc9c077d05db0b720f83e4b7c2bd0841b71f00528d647fae823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Biopsy</topic><topic>Cancer</topic><topic>Diagnosis</topic><topic>Diagnostic systems</topic><topic>Disease</topic><topic>Endoscopy</topic><topic>Family medical history</topic><topic>Gastric cancer</topic><topic>Gastrin</topic><topic>Gastritis</topic><topic>Genetic aspects</topic><topic>Genetics</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Immunoglobulin G</topic><topic>Medical diagnosis</topic><topic>Medicine and Health Sciences</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Sensitivity</topic><topic>Stomach cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dondov, Ganchimeg</creatorcontrib><creatorcontrib>Amarbayasgalan, Dashmaa</creatorcontrib><creatorcontrib>Batsaikhan, Batbold</creatorcontrib><creatorcontrib>Badamjav, Tegshjargal</creatorcontrib><creatorcontrib>Batbaatar, Batchimeg</creatorcontrib><creatorcontrib>Tuvdenjamts, Baljinnyam</creatorcontrib><creatorcontrib>Tumurbat, Nasanjargal</creatorcontrib><creatorcontrib>Davaa, Bayar</creatorcontrib><creatorcontrib>Purevdorj, Erkhembulgan</creatorcontrib><creatorcontrib>Nyamaa, Bayarmaa</creatorcontrib><creatorcontrib>Lonjid, 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Tarek</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic performances of pepsinogens and gastrin-17 for atrophic gastritis and gastric cancer in Mongolian subjects</atitle><jtitle>PloS one</jtitle><date>2022-10-17</date><risdate>2022</risdate><volume>17</volume><issue>10</issue><spage>e0274938</spage><epage>e0274938</epage><pages>e0274938-e0274938</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>In Mongolia, gastric cancer morbidity and mortality are high, and more than 80 percent of cases are diagnosed at an advanced stage. This study aimed to evaluate pepsinogens (PGIs) and gastrin-17 (G-17) levels and to determine the diagnostic performances for gastric cancer and chronic atrophic gastritis among Mongolian individuals. We enrolled a total of 120 subjects, including gastric cancer (40), atrophic gastritis (40), and healthy control (40), matched by age (±2) and sex. Pepsinogen I (PGI), Pepsinogen II (PGII), G-17, and H. pylori IgG levels were measured using GastroPanel ELISA kit (Biohit, Helsinki, Finland). Also, PGI to PGII ratio (PGR) was calculated. For atrophic gastritis, when the optimal cut-off value of PGI was [less than or equal to]75.07 ng/ml, the sensitivity and specificity were 75% and 50%, respectively; when the optimal cut-off value of PGR was [less than or equal to]6.25, sensitivity and specificity were 85% and 44.7%, respectively. For gastric cancer, when the optimal cut-off value of PGI was [less than or equal to]35.25 ng/ml, the sensitivity and specificity were 47.2% and 86.8%, respectively; when the optimal cut-off value of PGR was [less than or equal to]5.27, sensitivity and specificity were 75% and 60.5%, respectively. Combinations of biomarkers with risk factors could improve diagnostic accuracy (AUC for atrophic gastritis 74.8, 95% CI 64.0-85.7, p<0.001; AUC for gastric cancer 75.5, 95% CI 64.2-86.8, p<0.001). PGI, PGR biomarkers combined with the risk of age, family history of gastric cancer, and previous gastric disease could not be an alternative test for upper endoscopy but might be a supportive method which is identifying individuals at medium- and high risk of gastric cancer and precancerous lesions who may need upper endoscopy.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>36251649</pmid><doi>10.1371/journal.pone.0274938</doi><tpages>e0274938</tpages><orcidid>https://orcid.org/0000-0002-2565-0347</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2022-10, Vol.17 (10), p.e0274938-e0274938 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Biology and Life Sciences Biomarkers Biopsy Cancer Diagnosis Diagnostic systems Disease Endoscopy Family medical history Gastric cancer Gastrin Gastritis Genetic aspects Genetics Health aspects Health risks Immunoglobulin G Medical diagnosis Medicine and Health Sciences Morbidity Mortality Risk analysis Risk factors Sensitivity Stomach cancer |
| title | Diagnostic performances of pepsinogens and gastrin-17 for atrophic gastritis and gastric cancer in Mongolian subjects |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T03%3A54%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Diagnostic%20performances%20of%20pepsinogens%20and%20gastrin-17%20for%20atrophic%20gastritis%20and%20gastric%20cancer%20in%20Mongolian%20subjects&rft.jtitle=PloS%20one&rft.au=Dondov,%20Ganchimeg&rft.date=2022-10-17&rft.volume=17&rft.issue=10&rft.spage=e0274938&rft.epage=e0274938&rft.pages=e0274938-e0274938&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0274938&rft_dat=%3Cgale_plos_%3EA722869598%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2725597878&rft_id=info:pmid/36251649&rft_galeid=A722869598&rft_doaj_id=oai_doaj_org_article_db782d7649fc47d8812d4ca046e8f424&rfr_iscdi=true |