Dynamical modeling of the H3K27 epigenetic landscape in mouse embryonic stem cells

The Polycomb system via the methylation of the lysine 27 of histone H3 (H3K27) plays central roles in the silencing of many lineage-specific genes during development. Recent experimental evidence suggested that the recruitment of histone modifying enzymes like the Polycomb repressive complex 2 (PRC2...

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Veröffentlicht in:	PLoS computational biology 2022-09, Vol.18 (9), p.e1010450-e1010450
Hauptverfasser:	Newar, Kapil, Abdulla, Amith Zafal, Salari, Hossein, Fanchon, Eric, Jost, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Analysis Biology and life sciences DNA methylation Dynamic models Embryo cells Embryonic stem cells Enzymes Epigenetic inheritance Epigenetics Gene expression Genes Genomes Histone H3 Histones Identification and classification Life Sciences Lysine Mathematical models Methylation Physical Sciences Polycomb group proteins Predictive maintenance Properties Proteins Qualitative analysis Recruitment Stem cell transplantation Stem cells
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