Mouse models of COVID-19 recapitulate inflammatory pathways rather than gene expression

How well mouse models recapitulate the transcriptional profiles seen in humans remains debatable, with both conservation and diversity identified in various settings. Herein we use RNA-Seq data and bioinformatics approaches to analyze the transcriptional responses in SARS-CoV-2 infected lungs, compa...

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Veröffentlicht in:	PLoS pathogens 2022-09, Vol.18 (9), p.e1010867-e1010867
Hauptverfasser:	Bishop, Cameron R, Dumenil, Troy, Rawle, Daniel J, Le, Thuy T, Yan, Kexin, Tang, Bing, Hartel, Gunter, Suhrbier, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Analysis Angiotensin-converting enzyme 2 Animal models Archives & records Bioinformatics Biology and life sciences Computational biology Coronaviruses COVID-19 Datasets Engineering and Technology Gene expression Genetic transcription Infections Inflammation Lungs Medicine and health sciences Pathways Research and Analysis Methods RNA sequencing Rodents Severe acute respiratory syndrome coronavirus 2 Viral diseases Viruses
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