Propensity score analysis comparing survival between definitive chemoradiotherapy and esophagectomy with adjuvant chemoradiotherapy in patients with esophageal squamous cell carcinoma
Introduction The purpose of the current study is to compare definitive chemoradiotherapy and esophagectomy with adjuvant chemoradiotherapy in patients with cT1-3/N0-3 esophageal squamous cell carcinoma in survival. Methods Records from 2008 to 2014 of 4931 patients with clinical T1-3/N0-3 esophageal...
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| description | Introduction The purpose of the current study is to compare definitive chemoradiotherapy and esophagectomy with adjuvant chemoradiotherapy in patients with cT1-3/N0-3 esophageal squamous cell carcinoma in survival. Methods Records from 2008 to 2014 of 4931 patients with clinical T1-3/N0-3 esophageal squamous cell carcinoma receiving definitive chemoradiotherapy or esophagectomy with adjuvant chemoradiotherapy were obtained from the Taiwan Cancer Registry. Univariable and multivariable analyses were performed and propensity score matching was used to minimize the bias. Overall survival was compared between definitive chemoradiotherapy and esophagectomy with adjuvant chemoradiotherapy, and also in the three different clinical stages. Results Definitive chemoradiotherapy was performed on 4381 patients, and 550 patients received esophagectomy adjuvant chemoradiotherapy. Each group produced 456 patients for comparison after propensity score matching. The 1-year, 2-year, and 3-year overall survival rates for matched patients in with definitive chemoradiotherapy group were 57.18%, 31.92%, and 23.8%. The 1-year, 2-year, and 3-year overall survival rates for matched patients treated in the esophagectomy with adjuvant chemoradiotherapy group were 72.35%, 45.74%, and 34.04%(p |
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| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2724598159</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A722244380</galeid><doaj_id>oai_doaj_org_article_85524a6ed2cd4db8ab2a4f65eeb0f19d</doaj_id><sourcerecordid>A722244380</sourcerecordid><originalsourceid>FETCH-LOGICAL-c618t-28b87d93ca041a0a1c0ea2ebd4efc471b16cdfe217f0734c1f0f5e7df05985123</originalsourceid><addsrcrecordid>eNqNk9tq3DAQhk1poWnaNyjUUCjpxW4l-bg3hRB6WAik9HQrxtLI1mJLjiRvuk_W16s265RsyUXRhcTom380P5okeUnJkmYVfbexkzPQL0drcElYRbOsfpSc0FXGFiUj2eN756fJM-83hBRZXZYnye8vzo5ovA671AvrMIWotPPap8IOIzht2tRPbqu30KcNhhtEk0pU2uigt5iKDgfrQGobOnQw7qKATNHbsYMWRbDDLr3RoUtBbqYtmPBAhjbpCEGjCf7A3qXHkv56gsFO8TnY96kAJ7SxAzxPnijoPb6Y99Pkx8cP3y8-Ly6vPq0vzi8XoqR1WLC6qSu5ygSQnAIBKggCw0bmqERe0YaWQipktFKkynJBFVEFVlKRYlUXlGWnyauD7thbz2ejPWcVyyNBi1Uk1gdCWtjw0ekB3I5b0Pw2YF3LwQUteuR1UbAcSpRMyFw2NTQMclUWiA1RdCWj1vu52tQMKEV0xEF_JHp8Y3THW7vlq6IklBVR4GwWcPZ6Qh_4oP3eOTAYTdy_u2AkJ7edvf4Hfbi7mWohNqCNsrGu2Ivy84oxludZTSK1fICKS-KgRfyVSsf4UcLbo4TIBPwVWpi85-tvX_-fvfp5zL65x3bxA4XO234K2hp_DOYHUDjrvUP112RK-H6o7tzg-6Hi81BlfwAs3hws</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2724598159</pqid></control><display><type>article</type><title>Propensity score analysis comparing survival between definitive chemoradiotherapy and esophagectomy with adjuvant chemoradiotherapy in patients with esophageal squamous cell carcinoma</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Chang, Yi-Lin ; Cheng, Ya-Fu ; Chen, Hui-Shan ; Wu, Siao-Chi ; Hung, Wei-Heng ; Chen, Heng-Chung ; Huang, Chang-Lun ; Cheng, Ching-Yuan ; Wang, Bing-Yen</creator><creatorcontrib>Chang, Yi-Lin ; Cheng, Ya-Fu ; Chen, Hui-Shan ; Wu, Siao-Chi ; Hung, Wei-Heng ; Chen, Heng-Chung ; Huang, Chang-Lun ; Cheng, Ching-Yuan ; Wang, Bing-Yen</creatorcontrib><description>Introduction The purpose of the current study is to compare definitive chemoradiotherapy and esophagectomy with adjuvant chemoradiotherapy in patients with cT1-3/N0-3 esophageal squamous cell carcinoma in survival. Methods Records from 2008 to 2014 of 4931 patients with clinical T1-3/N0-3 esophageal squamous cell carcinoma receiving definitive chemoradiotherapy or esophagectomy with adjuvant chemoradiotherapy were obtained from the Taiwan Cancer Registry. Univariable and multivariable analyses were performed and propensity score matching was used to minimize the bias. Overall survival was compared between definitive chemoradiotherapy and esophagectomy with adjuvant chemoradiotherapy, and also in the three different clinical stages. Results Definitive chemoradiotherapy was performed on 4381 patients, and 550 patients received esophagectomy adjuvant chemoradiotherapy. Each group produced 456 patients for comparison after propensity score matching. The 1-year, 2-year, and 3-year overall survival rates for matched patients in with definitive chemoradiotherapy group were 57.18%, 31.92%, and 23.8%. The 1-year, 2-year, and 3-year overall survival rates for matched patients treated in the esophagectomy with adjuvant chemoradiotherapy group were 72.35%, 45.74%, and 34.04%(p<0.0001). In multivariable analysis, treatment modality was an independent prognostic factor. Esophagectomy with adjuvant chemoradiotherapy provided better survival outcome than definitive chemoradiotherapy for patients with clinical stage II/III disease. As for patients with clinical stage I disease, there was no significant survival difference between definitive chemoradiotherapy and esophagectomy with adjuvant chemoradiotherapy. Conclusions Esophagectomy with adjuvant chemoradiotherapy provided better survival than definitive chemoradiotherapy in clinical II/III esophageal squamous cell carcinoma. However, more data are needed to conduct a convincing conclusion in clinical stage I patients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0271338</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Bias ; Cancer ; Care and treatment ; Cell survival ; Chemoradiotherapy ; Chemotherapy ; Complications and side effects ; Esophageal cancer ; Esophagus ; Matching ; Medical prognosis ; Medicine and Health Sciences ; Patient outcomes ; Patients ; Radiation therapy ; Squamous cell carcinoma ; Statistical analysis ; Surgery ; Survival ; Survival analysis</subject><ispartof>PloS one, 2022-10, Vol.17 (10), p.e0271338-e0271338</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Chang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Chang et al 2022 Chang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c618t-28b87d93ca041a0a1c0ea2ebd4efc471b16cdfe217f0734c1f0f5e7df05985123</cites><orcidid>0000-0001-5510-3865 ; 0000-0001-8949-1034</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9560125/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9560125/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids></links><search><creatorcontrib>Chang, Yi-Lin</creatorcontrib><creatorcontrib>Cheng, Ya-Fu</creatorcontrib><creatorcontrib>Chen, Hui-Shan</creatorcontrib><creatorcontrib>Wu, Siao-Chi</creatorcontrib><creatorcontrib>Hung, Wei-Heng</creatorcontrib><creatorcontrib>Chen, Heng-Chung</creatorcontrib><creatorcontrib>Huang, Chang-Lun</creatorcontrib><creatorcontrib>Cheng, Ching-Yuan</creatorcontrib><creatorcontrib>Wang, Bing-Yen</creatorcontrib><title>Propensity score analysis comparing survival between definitive chemoradiotherapy and esophagectomy with adjuvant chemoradiotherapy in patients with esophageal squamous cell carcinoma</title><title>PloS one</title><description>Introduction The purpose of the current study is to compare definitive chemoradiotherapy and esophagectomy with adjuvant chemoradiotherapy in patients with cT1-3/N0-3 esophageal squamous cell carcinoma in survival. Methods Records from 2008 to 2014 of 4931 patients with clinical T1-3/N0-3 esophageal squamous cell carcinoma receiving definitive chemoradiotherapy or esophagectomy with adjuvant chemoradiotherapy were obtained from the Taiwan Cancer Registry. Univariable and multivariable analyses were performed and propensity score matching was used to minimize the bias. Overall survival was compared between definitive chemoradiotherapy and esophagectomy with adjuvant chemoradiotherapy, and also in the three different clinical stages. Results Definitive chemoradiotherapy was performed on 4381 patients, and 550 patients received esophagectomy adjuvant chemoradiotherapy. Each group produced 456 patients for comparison after propensity score matching. The 1-year, 2-year, and 3-year overall survival rates for matched patients in with definitive chemoradiotherapy group were 57.18%, 31.92%, and 23.8%. The 1-year, 2-year, and 3-year overall survival rates for matched patients treated in the esophagectomy with adjuvant chemoradiotherapy group were 72.35%, 45.74%, and 34.04%(p<0.0001). In multivariable analysis, treatment modality was an independent prognostic factor. Esophagectomy with adjuvant chemoradiotherapy provided better survival outcome than definitive chemoradiotherapy for patients with clinical stage II/III disease. As for patients with clinical stage I disease, there was no significant survival difference between definitive chemoradiotherapy and esophagectomy with adjuvant chemoradiotherapy. Conclusions Esophagectomy with adjuvant chemoradiotherapy provided better survival than definitive chemoradiotherapy in clinical II/III esophageal squamous cell carcinoma. However, more data are needed to conduct a convincing conclusion in clinical stage I patients.</description><subject>Bias</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Cell survival</subject><subject>Chemoradiotherapy</subject><subject>Chemotherapy</subject><subject>Complications and side effects</subject><subject>Esophageal cancer</subject><subject>Esophagus</subject><subject>Matching</subject><subject>Medical prognosis</subject><subject>Medicine and Health Sciences</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Radiation therapy</subject><subject>Squamous cell carcinoma</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Survival</subject><subject>Survival 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score analysis comparing survival between definitive chemoradiotherapy and esophagectomy with adjuvant chemoradiotherapy in patients with esophageal squamous cell carcinoma</title><author>Chang, Yi-Lin ; Cheng, Ya-Fu ; Chen, Hui-Shan ; Wu, Siao-Chi ; Hung, Wei-Heng ; Chen, Heng-Chung ; Huang, Chang-Lun ; Cheng, Ching-Yuan ; Wang, Bing-Yen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c618t-28b87d93ca041a0a1c0ea2ebd4efc471b16cdfe217f0734c1f0f5e7df05985123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Bias</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Cell survival</topic><topic>Chemoradiotherapy</topic><topic>Chemotherapy</topic><topic>Complications and side effects</topic><topic>Esophageal cancer</topic><topic>Esophagus</topic><topic>Matching</topic><topic>Medical prognosis</topic><topic>Medicine and Health Sciences</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Radiation therapy</topic><topic>Squamous cell carcinoma</topic><topic>Statistical analysis</topic><topic>Surgery</topic><topic>Survival</topic><topic>Survival analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Yi-Lin</creatorcontrib><creatorcontrib>Cheng, Ya-Fu</creatorcontrib><creatorcontrib>Chen, Hui-Shan</creatorcontrib><creatorcontrib>Wu, Siao-Chi</creatorcontrib><creatorcontrib>Hung, Wei-Heng</creatorcontrib><creatorcontrib>Chen, Heng-Chung</creatorcontrib><creatorcontrib>Huang, Chang-Lun</creatorcontrib><creatorcontrib>Cheng, Ching-Yuan</creatorcontrib><creatorcontrib>Wang, Bing-Yen</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts 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titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Yi-Lin</au><au>Cheng, Ya-Fu</au><au>Chen, Hui-Shan</au><au>Wu, Siao-Chi</au><au>Hung, Wei-Heng</au><au>Chen, Heng-Chung</au><au>Huang, Chang-Lun</au><au>Cheng, Ching-Yuan</au><au>Wang, Bing-Yen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Propensity score analysis comparing survival between definitive chemoradiotherapy and esophagectomy with adjuvant chemoradiotherapy in patients with esophageal squamous cell carcinoma</atitle><jtitle>PloS one</jtitle><date>2022-10-13</date><risdate>2022</risdate><volume>17</volume><issue>10</issue><spage>e0271338</spage><epage>e0271338</epage><pages>e0271338-e0271338</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Introduction The purpose of the current study is to compare definitive chemoradiotherapy and esophagectomy with adjuvant chemoradiotherapy in patients with cT1-3/N0-3 esophageal squamous cell carcinoma in survival. Methods Records from 2008 to 2014 of 4931 patients with clinical T1-3/N0-3 esophageal squamous cell carcinoma receiving definitive chemoradiotherapy or esophagectomy with adjuvant chemoradiotherapy were obtained from the Taiwan Cancer Registry. Univariable and multivariable analyses were performed and propensity score matching was used to minimize the bias. Overall survival was compared between definitive chemoradiotherapy and esophagectomy with adjuvant chemoradiotherapy, and also in the three different clinical stages. Results Definitive chemoradiotherapy was performed on 4381 patients, and 550 patients received esophagectomy adjuvant chemoradiotherapy. Each group produced 456 patients for comparison after propensity score matching. The 1-year, 2-year, and 3-year overall survival rates for matched patients in with definitive chemoradiotherapy group were 57.18%, 31.92%, and 23.8%. The 1-year, 2-year, and 3-year overall survival rates for matched patients treated in the esophagectomy with adjuvant chemoradiotherapy group were 72.35%, 45.74%, and 34.04%(p<0.0001). In multivariable analysis, treatment modality was an independent prognostic factor. Esophagectomy with adjuvant chemoradiotherapy provided better survival outcome than definitive chemoradiotherapy for patients with clinical stage II/III disease. As for patients with clinical stage I disease, there was no significant survival difference between definitive chemoradiotherapy and esophagectomy with adjuvant chemoradiotherapy. Conclusions Esophagectomy with adjuvant chemoradiotherapy provided better survival than definitive chemoradiotherapy in clinical II/III esophageal squamous cell carcinoma. However, more data are needed to conduct a convincing conclusion in clinical stage I patients.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><doi>10.1371/journal.pone.0271338</doi><tpages>e0271338</tpages><orcidid>https://orcid.org/0000-0001-5510-3865</orcidid><orcidid>https://orcid.org/0000-0001-8949-1034</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Bias Cancer Care and treatment Cell survival Chemoradiotherapy Chemotherapy Complications and side effects Esophageal cancer Esophagus Matching Medical prognosis Medicine and Health Sciences Patient outcomes Patients Radiation therapy Squamous cell carcinoma Statistical analysis Surgery Survival Survival analysis |
| title | Propensity score analysis comparing survival between definitive chemoradiotherapy and esophagectomy with adjuvant chemoradiotherapy in patients with esophageal squamous cell carcinoma |
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