HDAC6 inhibitor ACY-1083 shows lung epithelial protective features in COPD

Airway epithelial damage is a common feature in respiratory diseases such as COPD and has been suggested to drive inflammation and progression of disease. These features manifest as remodeling and destruction of lung epithelial characteristics including loss of small airways which contributes to chr...

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Veröffentlicht in:	PloS one 2022-10, Vol.17 (10), p.e0266310-e0266310
Hauptverfasser:	Horndahl, Jenny, Svärd, Rebecka, Berntsson, Pia, Wingren, Cecilia, Li, Jingjing, Abdillahi, Suado M, Ghosh, Baishakhi, Capodanno, Erin, Chan, Justin, Ripa, Lena, Åstrand, Annika, Sidhaye, Venkataramana K, Collins, Mia
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Beat frequencies Biology and Life Sciences Cell culture Cell cycle Chronic obstructive pulmonary disease Cigarette smoke Cilia Cilia beat frequency Cytokines Damage Diagnosis Epithelium Genetic aspects Histone deacetylase Immunohistochemistry Inflammation Inhibitors Lung diseases, Obstructive Lungs Medicine and Health Sciences Mesenchyme Mucin Mucins Oxidative stress Permeability Physical Sciences Proteins Recovery of function Research and Analysis Methods Respiratory diseases Respiratory tract Respiratory tract diseases Selectivity Social Sciences Structure-function relationships Tumor necrosis factor
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