Immunomodulatory effects of chicken cathelicidin-2 on a primary hepatic cell co-culture model

Cathelicidin-2 is an antimicrobial peptide (AMP) produced as part of the innate immune system of chickens and might be a new candidate to combat infection and inflammation within the gut-liver axis. Studying the hepatic immune response is of high importance as the liver is primarily exposed to gut-d...

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Veröffentlicht in:	PloS one 2022-10, Vol.17 (10), p.e0275847-e0275847
Hauptverfasser:	Sebok, Csilla, Walmsley, Stephanie, Tráj, Patrik, Mackei, Máté, Vörösházi, Júlia, Petrilla, Janka, Kovács, László, Kemény, Ágnes, Neogrády, Zsuzsanna, Mátis, Gábor
Format:	Artikel
Sprache:	eng
Schlagworte:	12-O-Tetradecanoylphorbol-13-acetate Acetic acid Analysis Animal protection Animal welfare Antibiotics Antiinfectives and antibacterials Antimicrobial peptides Biology and Life Sciences Cathelicidins Cell culture Cell viability Chickens Colony-stimulating factor Cytokines Drug development Drug discovery Health aspects Homeostasis Hydrogen peroxide Immune response Immune system Immunomodulation Inflammation Innate immunity Integrity Interferon Interleukin 10 L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Lipid peroxidation Lipids Lipoteichoic acid Liver Macrophage colony stimulating factor Macrophages Medicine and Health Sciences Membranes Methods Mode of action Oxidative stress Oxygen Peptides Peroxidation Pharmaceutical industry Poultry Product development Properties Reactive oxygen species Research and Analysis Methods Tumor necrosis factor-TNF γ-Interferon
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