Transcriptional changes in Plasmodium falciparum upon conditional knock down of mitochondrial ribosomal proteins RSM22 and L23

The mitochondrion of malaria parasites is an attractive antimalarial drug target, which require mitoribosomes to translate genes encoded in the mitochondrial (mt) DNA. Plasmodium mitoribosomes are composed of highly fragmented ribosomal RNA (rRNA) encoded in the mtDNA. All mitoribosomal proteins (MR...

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Veröffentlicht in:	PloS one 2022-10, Vol.17 (10), p.e0274993-e0274993
Hauptverfasser:	Dass, Swati, Mather, Michael W, Morrisey, Joanne M, Ling, Liqin, Vaidya, Akhil B, Ke, Hangjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antimalarial agents Antimalarials - therapeutic use Assembly Atovaquone Atovaquone - pharmacology Biology and Life Sciences Cloning CRISPR Cytochrome Cytochrome bc1 Cytochromes Deoxyribonucleic acid DNA DNA, Mitochondrial - metabolism E coli Electron Transport Complex III - metabolism Gene sequencing Genetic aspects Genetic transcription Genomes Humans Identification and classification Malaria Malaria, Falciparum - drug therapy Metabolic pathways Mitochondria - metabolism Mitochondrial DNA Mitochondrial Proteins - metabolism Organisms Parasites Plasmids Plasmodium Plasmodium - genetics Plasmodium falciparum Proteins Research and analysis methods Ribonucleic acid Ribosomal proteins Ribosomal Proteins - genetics Ribosomal Proteins - metabolism RNA RNA, Ribosomal - genetics rRNA Therapeutic targets Transcription, Genetic Transcriptomics Vector-borne diseases
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