Assessment of oxidative stress markers in elderly patients with SARS-CoV-2 infection and potential prognostic implications in the medium and long term
We aimed to evaluate the correlation of plasma levels of thiobarbituric acid reactive substances (TBARS) and reduced thiols with morbidity, mortality and immune response during and after SARS-CoV-2 infection. This was an observational study that included inpatients with SARS-CoV-2 infection older th...
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| creator | Vazquez-Agra, Nestor Marques-Afonso, Ana-Teresa Cruces-Sande, Anton Novo-Veleiro, Ignacio Pose-Reino, Antonio Mendez-Alvarez, Estefania Soto-Otero, Ramon Hermida-Ameijeiras, Alvaro |
| description | We aimed to evaluate the correlation of plasma levels of thiobarbituric acid reactive substances (TBARS) and reduced thiols with morbidity, mortality and immune response during and after SARS-CoV-2 infection. This was an observational study that included inpatients with SARS-CoV-2 infection older than 65 years. The individuals were followed up to the twelfth month post-discharge. Plasma levels of TBARS and reduced thiols were quantified as a measure of lipid and protein oxidation, respectively. Fatal and non-fatal events were evaluated during admission and at the third, sixth and twelfth month post-discharge. Differences in oxidative stress markers between the groups of interest, time to a negative RT-qPCR and time to significant anti-SARS-CoV-2 IgM titers were assessed. We included 61 patients (57% women) with a mean age of 83 years old. After multivariate analysis, we found differences in TBARS and reduced thiol levels between the comparison groups in fatal and non-fatal events during hospital admission. TBARS levels were also correlated with fatal events at the 6.sup.th and 12.sup.th months post-discharge. One year after hospital discharge, other predictors rather than oxidative stress markers were relevant in the models. The median time to reach significant anti-SARS-CoV-2 IgM titers was lower in patients with low levels of reduced thiols. Assessment of some parameters related to oxidative stress may help identify groups of patients with a higher risk of morbidity, mortality and delayed immune response during and after SARS-CoV-2 infection. |
| doi_str_mv | 10.1371/journal.pone.0268871 |
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This was an observational study that included inpatients with SARS-CoV-2 infection older than 65 years. The individuals were followed up to the twelfth month post-discharge. Plasma levels of TBARS and reduced thiols were quantified as a measure of lipid and protein oxidation, respectively. Fatal and non-fatal events were evaluated during admission and at the third, sixth and twelfth month post-discharge. Differences in oxidative stress markers between the groups of interest, time to a negative RT-qPCR and time to significant anti-SARS-CoV-2 IgM titers were assessed. We included 61 patients (57% women) with a mean age of 83 years old. After multivariate analysis, we found differences in TBARS and reduced thiol levels between the comparison groups in fatal and non-fatal events during hospital admission. TBARS levels were also correlated with fatal events at the 6.sup.th and 12.sup.th months post-discharge. One year after hospital discharge, other predictors rather than oxidative stress markers were relevant in the models. The median time to reach significant anti-SARS-CoV-2 IgM titers was lower in patients with low levels of reduced thiols. Assessment of some parameters related to oxidative stress may help identify groups of patients with a higher risk of morbidity, mortality and delayed immune response during and after SARS-CoV-2 infection.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0268871</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Aged patients ; Biology and life sciences ; Blood ; Diabetes ; Disease ; Dyspnea ; Evaluation ; Hospitals ; Immune response ; Immune system ; Immunoglobulin M ; Infections ; Laboratories ; Lipid peroxidation ; Lipids ; Markers ; Medical prognosis ; Medicine and health sciences ; Morbidity ; Mortality ; Multivariate analysis ; Older people ; Oxidation ; Oxidative stress ; Parameter identification ; Patients ; Physical Sciences ; Physiology ; Plasma ; Plasma levels ; Prognosis ; Proteins ; Sample size ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Statistical analysis ; Thiobarbituric acid ; Thiols ; Tumor necrosis factor-TNF</subject><ispartof>PloS one, 2022-10, Vol.17 (10), p.e0268871-e0268871</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Vazquez-Agra et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Vazquez-Agra et al 2022 Vazquez-Agra et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c669t-782c6ea5d1c992e4ad633c70c02a10405f5923c15e92edac7da25e6a61ace3b73</citedby><cites>FETCH-LOGICAL-c669t-782c6ea5d1c992e4ad633c70c02a10405f5923c15e92edac7da25e6a61ace3b73</cites><orcidid>0000-0002-8318-1710 ; 0000-0003-0079-0279 ; 0000-0003-3227-8990 ; 0000-0002-9121-2441</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536629/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536629/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53770,53772,79347,79348</link.rule.ids></links><search><contributor>Nasrallah, Gheyath K.</contributor><creatorcontrib>Vazquez-Agra, Nestor</creatorcontrib><creatorcontrib>Marques-Afonso, Ana-Teresa</creatorcontrib><creatorcontrib>Cruces-Sande, Anton</creatorcontrib><creatorcontrib>Novo-Veleiro, Ignacio</creatorcontrib><creatorcontrib>Pose-Reino, Antonio</creatorcontrib><creatorcontrib>Mendez-Alvarez, Estefania</creatorcontrib><creatorcontrib>Soto-Otero, Ramon</creatorcontrib><creatorcontrib>Hermida-Ameijeiras, Alvaro</creatorcontrib><title>Assessment of oxidative stress markers in elderly patients with SARS-CoV-2 infection and potential prognostic implications in the medium and long term</title><title>PloS one</title><description>We aimed to evaluate the correlation of plasma levels of thiobarbituric acid reactive substances (TBARS) and reduced thiols with morbidity, mortality and immune response during and after SARS-CoV-2 infection. This was an observational study that included inpatients with SARS-CoV-2 infection older than 65 years. The individuals were followed up to the twelfth month post-discharge. Plasma levels of TBARS and reduced thiols were quantified as a measure of lipid and protein oxidation, respectively. Fatal and non-fatal events were evaluated during admission and at the third, sixth and twelfth month post-discharge. Differences in oxidative stress markers between the groups of interest, time to a negative RT-qPCR and time to significant anti-SARS-CoV-2 IgM titers were assessed. We included 61 patients (57% women) with a mean age of 83 years old. After multivariate analysis, we found differences in TBARS and reduced thiol levels between the comparison groups in fatal and non-fatal events during hospital admission. TBARS levels were also correlated with fatal events at the 6.sup.th and 12.sup.th months post-discharge. One year after hospital discharge, other predictors rather than oxidative stress markers were relevant in the models. The median time to reach significant anti-SARS-CoV-2 IgM titers was lower in patients with low levels of reduced thiols. Assessment of some parameters related to oxidative stress may help identify groups of patients with a higher risk of morbidity, mortality and delayed immune response during and after SARS-CoV-2 infection.</description><subject>Aged patients</subject><subject>Biology and life sciences</subject><subject>Blood</subject><subject>Diabetes</subject><subject>Disease</subject><subject>Dyspnea</subject><subject>Evaluation</subject><subject>Hospitals</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunoglobulin M</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Markers</subject><subject>Medical prognosis</subject><subject>Medicine and health sciences</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Multivariate analysis</subject><subject>Older people</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Parameter identification</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Physiology</subject><subject>Plasma</subject><subject>Plasma levels</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Sample size</subject><subject>Severe acute respiratory syndrome</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Statistical analysis</subject><subject>Thiobarbituric acid</subject><subject>Thiols</subject><subject>Tumor necrosis 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of oxidative stress markers in elderly patients with SARS-CoV-2 infection and potential prognostic implications in the medium and long term</title><author>Vazquez-Agra, Nestor ; Marques-Afonso, Ana-Teresa ; Cruces-Sande, Anton ; Novo-Veleiro, Ignacio ; Pose-Reino, Antonio ; Mendez-Alvarez, Estefania ; Soto-Otero, Ramon ; Hermida-Ameijeiras, Alvaro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c669t-782c6ea5d1c992e4ad633c70c02a10405f5923c15e92edac7da25e6a61ace3b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aged patients</topic><topic>Biology and life sciences</topic><topic>Blood</topic><topic>Diabetes</topic><topic>Disease</topic><topic>Dyspnea</topic><topic>Evaluation</topic><topic>Hospitals</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunoglobulin M</topic><topic>Infections</topic><topic>Laboratories</topic><topic>Lipid 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This was an observational study that included inpatients with SARS-CoV-2 infection older than 65 years. The individuals were followed up to the twelfth month post-discharge. Plasma levels of TBARS and reduced thiols were quantified as a measure of lipid and protein oxidation, respectively. Fatal and non-fatal events were evaluated during admission and at the third, sixth and twelfth month post-discharge. Differences in oxidative stress markers between the groups of interest, time to a negative RT-qPCR and time to significant anti-SARS-CoV-2 IgM titers were assessed. We included 61 patients (57% women) with a mean age of 83 years old. After multivariate analysis, we found differences in TBARS and reduced thiol levels between the comparison groups in fatal and non-fatal events during hospital admission. TBARS levels were also correlated with fatal events at the 6.sup.th and 12.sup.th months post-discharge. One year after hospital discharge, other predictors rather than oxidative stress markers were relevant in the models. The median time to reach significant anti-SARS-CoV-2 IgM titers was lower in patients with low levels of reduced thiols. Assessment of some parameters related to oxidative stress may help identify groups of patients with a higher risk of morbidity, mortality and delayed immune response during and after SARS-CoV-2 infection.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><doi>10.1371/journal.pone.0268871</doi><tpages>e0268871</tpages><orcidid>https://orcid.org/0000-0002-8318-1710</orcidid><orcidid>https://orcid.org/0000-0003-0079-0279</orcidid><orcidid>https://orcid.org/0000-0003-3227-8990</orcidid><orcidid>https://orcid.org/0000-0002-9121-2441</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged patients Biology and life sciences Blood Diabetes Disease Dyspnea Evaluation Hospitals Immune response Immune system Immunoglobulin M Infections Laboratories Lipid peroxidation Lipids Markers Medical prognosis Medicine and health sciences Morbidity Mortality Multivariate analysis Older people Oxidation Oxidative stress Parameter identification Patients Physical Sciences Physiology Plasma Plasma levels Prognosis Proteins Sample size Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Statistical analysis Thiobarbituric acid Thiols Tumor necrosis factor-TNF |
| title | Assessment of oxidative stress markers in elderly patients with SARS-CoV-2 infection and potential prognostic implications in the medium and long term |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T12%3A56%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Assessment%20of%20oxidative%20stress%20markers%20in%20elderly%20patients%20with%20SARS-CoV-2%20infection%20and%20potential%20prognostic%20implications%20in%20the%20medium%20and%20long%20term&rft.jtitle=PloS%20one&rft.au=Vazquez-Agra,%20Nestor&rft.date=2022-10-06&rft.volume=17&rft.issue=10&rft.spage=e0268871&rft.epage=e0268871&rft.pages=e0268871-e0268871&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0268871&rft_dat=%3Cgale_plos_%3EA721201444%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2722285233&rft_id=info:pmid/&rft_galeid=A721201444&rft_doaj_id=oai_doaj_org_article_3322ee77fb7444a1aec9a034c088c5b9&rfr_iscdi=true |