Are interferon-gamma release assays reliable to detect tuberculosis infection in patients with rheumatoid arthritis treated with Janus kinase inhibitors?

Screening for latent tuberculosis infection is recommended in patients with rheumatoid arthritis (RA) starting Janus kinase inhibitors (Jaki). Interferon (IFN)-gamma release assays (IGRAs) are increasingly used for this purpose. Jaki tend to decrease the levels of IFNs, questioning the reliability o...

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Veröffentlicht in:	PloS one 2022-09, Vol.17 (9), p.e0275329-e0275329
Hauptverfasser:	Scrivo, Rossana, Molteni, Emanuele, Castellani, Chiara, Altobelli, Alessio, Alessandri, Cristiano, Ceccarelli, Fulvia, Di Franco, Manuela, Priori, Roberta, Riccieri, Valeria, Sili Scavalli, Antonio, Spinelli, Francesca Romana, Mastroianni, Claudio Maria, Conti, Fabrizio
Format:	Artikel
Sprache:	eng
Schlagworte:	Agreements Arthritis Biology and Life Sciences Care and treatment Chest Diagnosis Glucocorticoids Gold Health aspects Health services Infections Inhibitors Interferon Interferon gamma Janus kinase Kinases Lymphocytes Medicine and Health Sciences Patients Radiography Rheumatoid arthritis Signal transduction Skin tests Statistical analysis Tuberculin Tuberculosis γ-Interferon
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