Describing characteristics and treatment patterns of patients hospitalized with COVID-19 by race and ethnicity in a national RWD during the early months of the pandemic
To describe differences by race and ethnicity in treatment patterns among hospitalized COVID-19 patients in the US from March-August 2020. Among patients in de-identified Optum electronic health record data hospitalized with COVID-19 (March-August 2020), we estimated odds ratios of receiving COVID-1...
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| Veröffentlicht in: | PloS one 2022-09, Vol.17 (9), p.e0267815 |
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| creator | Vititoe, Sarah E Easthausen, Imaani J Lasky, Tamar Chakravarty, Aloka Bradley, Marie C Roe, Laura M Gatto, Nicolle M Weckstein, Andrew R Garry, Elizabeth M |
| description | To describe differences by race and ethnicity in treatment patterns among hospitalized COVID-19 patients in the US from March-August 2020.
Among patients in de-identified Optum electronic health record data hospitalized with COVID-19 (March-August 2020), we estimated odds ratios of receiving COVID-19 treatments of interest (azithromycin, dexamethasone, hydroxychloroquine, remdesivir, and other steroids) at hospital admission, by race and ethnicity, after adjusting for key covariates of interest.
After adjusting for key covariates, Black/African American patients were less likely to receive dexamethasone (adj. OR [95% CI]: 0.83 [0.71, 0.96]) and more likely to receive other steroids corticosteroids (adj. OR [95% CI]: 2.13 [1.90, 2.39]), relative to White patients. Hispanic/Latino patients were less likely to receive dexamethasone than Not Hispanic/Latino patients (adj. OR [95% CI]: 0.69 [0.58, 0.82]).
Our findings suggest that COVID-19 treatments patients received in Optum varied by race and ethnicity after adjustment for other possible explanatory factors. In the face of rapidly evolving treatment landscapes, policies are needed to ensure equitable access to novel and repurposed therapeutics to avoid disparities in care by race and ethnicity. |
| doi_str_mv | 10.1371/journal.pone.0267815 |
| format | Article |
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Among patients in de-identified Optum electronic health record data hospitalized with COVID-19 (March-August 2020), we estimated odds ratios of receiving COVID-19 treatments of interest (azithromycin, dexamethasone, hydroxychloroquine, remdesivir, and other steroids) at hospital admission, by race and ethnicity, after adjusting for key covariates of interest.
After adjusting for key covariates, Black/African American patients were less likely to receive dexamethasone (adj. OR [95% CI]: 0.83 [0.71, 0.96]) and more likely to receive other steroids corticosteroids (adj. OR [95% CI]: 2.13 [1.90, 2.39]), relative to White patients. Hispanic/Latino patients were less likely to receive dexamethasone than Not Hispanic/Latino patients (adj. OR [95% CI]: 0.69 [0.58, 0.82]).
Our findings suggest that COVID-19 treatments patients received in Optum varied by race and ethnicity after adjustment for other possible explanatory factors. In the face of rapidly evolving treatment landscapes, policies are needed to ensure equitable access to novel and repurposed therapeutics to avoid disparities in care by race and ethnicity.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0267815</identifier><identifier>PMID: 36155644</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>African Americans ; Age ; Analysis ; Azithromycin ; Azithromycin - therapeutic use ; Care and treatment ; Comorbidity ; Computer and Information Sciences ; Coronaviruses ; Corticoids ; Corticosteroids ; COVID-19 ; COVID-19 - epidemiology ; COVID-19 Drug Treatment ; Demographic aspects ; Dexamethasone ; Dexamethasone - therapeutic use ; Economic aspects ; Electronic health records ; Electronic medical records ; Ethnicity ; Frailty ; Health care disparities ; Health disparities ; Hispanic Americans ; Hospital patients ; Hospitalization ; Humans ; Hydroxychloroquine ; Hydroxychloroquine - therapeutic use ; Hypothesis testing ; Medical records ; Medicine and Health Sciences ; Minority & ethnic groups ; Obesity ; Overweight ; Pandemics ; Patients ; People and Places ; Race ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Social Sciences ; Steroid hormones ; Steroids ; United States ; Ventilation ; White People</subject><ispartof>PloS one, 2022-09, Vol.17 (9), p.e0267815</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c641t-471d2858ab218c39830ca55e75f0280ddd7d87b6c1cedd9f20a253b1b60664d73</cites><orcidid>0000-0003-2331-3053 ; 0000-0003-3466-9928 ; 0000-0002-5871-1599</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512177/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512177/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36155644$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kardeş, Sinan</contributor><creatorcontrib>Vititoe, Sarah E</creatorcontrib><creatorcontrib>Easthausen, Imaani J</creatorcontrib><creatorcontrib>Lasky, Tamar</creatorcontrib><creatorcontrib>Chakravarty, Aloka</creatorcontrib><creatorcontrib>Bradley, Marie C</creatorcontrib><creatorcontrib>Roe, Laura M</creatorcontrib><creatorcontrib>Gatto, Nicolle M</creatorcontrib><creatorcontrib>Weckstein, Andrew R</creatorcontrib><creatorcontrib>Garry, Elizabeth M</creatorcontrib><title>Describing characteristics and treatment patterns of patients hospitalized with COVID-19 by race and ethnicity in a national RWD during the early months of the pandemic</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To describe differences by race and ethnicity in treatment patterns among hospitalized COVID-19 patients in the US from March-August 2020.
Among patients in de-identified Optum electronic health record data hospitalized with COVID-19 (March-August 2020), we estimated odds ratios of receiving COVID-19 treatments of interest (azithromycin, dexamethasone, hydroxychloroquine, remdesivir, and other steroids) at hospital admission, by race and ethnicity, after adjusting for key covariates of interest.
After adjusting for key covariates, Black/African American patients were less likely to receive dexamethasone (adj. OR [95% CI]: 0.83 [0.71, 0.96]) and more likely to receive other steroids corticosteroids (adj. OR [95% CI]: 2.13 [1.90, 2.39]), relative to White patients. Hispanic/Latino patients were less likely to receive dexamethasone than Not Hispanic/Latino patients (adj. OR [95% CI]: 0.69 [0.58, 0.82]).
Our findings suggest that COVID-19 treatments patients received in Optum varied by race and ethnicity after adjustment for other possible explanatory factors. In the face of rapidly evolving treatment landscapes, policies are needed to ensure equitable access to novel and repurposed therapeutics to avoid disparities in care by race and ethnicity.</description><subject>African Americans</subject><subject>Age</subject><subject>Analysis</subject><subject>Azithromycin</subject><subject>Azithromycin - therapeutic use</subject><subject>Care and treatment</subject><subject>Comorbidity</subject><subject>Computer and Information Sciences</subject><subject>Coronaviruses</subject><subject>Corticoids</subject><subject>Corticosteroids</subject><subject>COVID-19</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 Drug Treatment</subject><subject>Demographic aspects</subject><subject>Dexamethasone</subject><subject>Dexamethasone - therapeutic use</subject><subject>Economic aspects</subject><subject>Electronic health records</subject><subject>Electronic medical records</subject><subject>Ethnicity</subject><subject>Frailty</subject><subject>Health care disparities</subject><subject>Health disparities</subject><subject>Hispanic Americans</subject><subject>Hospital patients</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Hydroxychloroquine</subject><subject>Hydroxychloroquine - therapeutic use</subject><subject>Hypothesis testing</subject><subject>Medical records</subject><subject>Medicine and Health Sciences</subject><subject>Minority & ethnic groups</subject><subject>Obesity</subject><subject>Overweight</subject><subject>Pandemics</subject><subject>Patients</subject><subject>People and Places</subject><subject>Race</subject><subject>SARS-CoV-2</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Social Sciences</subject><subject>Steroid hormones</subject><subject>Steroids</subject><subject>United States</subject><subject>Ventilation</subject><subject>White 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by race and ethnicity in a national RWD during the early months of the pandemic</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2022-09-26</date><risdate>2022</risdate><volume>17</volume><issue>9</issue><spage>e0267815</spage><pages>e0267815-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To describe differences by race and ethnicity in treatment patterns among hospitalized COVID-19 patients in the US from March-August 2020.
Among patients in de-identified Optum electronic health record data hospitalized with COVID-19 (March-August 2020), we estimated odds ratios of receiving COVID-19 treatments of interest (azithromycin, dexamethasone, hydroxychloroquine, remdesivir, and other steroids) at hospital admission, by race and ethnicity, after adjusting for key covariates of interest.
After adjusting for key covariates, Black/African American patients were less likely to receive dexamethasone (adj. OR [95% CI]: 0.83 [0.71, 0.96]) and more likely to receive other steroids corticosteroids (adj. OR [95% CI]: 2.13 [1.90, 2.39]), relative to White patients. Hispanic/Latino patients were less likely to receive dexamethasone than Not Hispanic/Latino patients (adj. OR [95% CI]: 0.69 [0.58, 0.82]).
Our findings suggest that COVID-19 treatments patients received in Optum varied by race and ethnicity after adjustment for other possible explanatory factors. In the face of rapidly evolving treatment landscapes, policies are needed to ensure equitable access to novel and repurposed therapeutics to avoid disparities in care by race and ethnicity.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>36155644</pmid><doi>10.1371/journal.pone.0267815</doi><tpages>e0267815</tpages><orcidid>https://orcid.org/0000-0003-2331-3053</orcidid><orcidid>https://orcid.org/0000-0003-3466-9928</orcidid><orcidid>https://orcid.org/0000-0002-5871-1599</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2022-09, Vol.17 (9), p.e0267815 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2718126315 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | African Americans Age Analysis Azithromycin Azithromycin - therapeutic use Care and treatment Comorbidity Computer and Information Sciences Coronaviruses Corticoids Corticosteroids COVID-19 COVID-19 - epidemiology COVID-19 Drug Treatment Demographic aspects Dexamethasone Dexamethasone - therapeutic use Economic aspects Electronic health records Electronic medical records Ethnicity Frailty Health care disparities Health disparities Hispanic Americans Hospital patients Hospitalization Humans Hydroxychloroquine Hydroxychloroquine - therapeutic use Hypothesis testing Medical records Medicine and Health Sciences Minority & ethnic groups Obesity Overweight Pandemics Patients People and Places Race SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Social Sciences Steroid hormones Steroids United States Ventilation White People |
| title | Describing characteristics and treatment patterns of patients hospitalized with COVID-19 by race and ethnicity in a national RWD during the early months of the pandemic |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T06%3A13%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Describing%20characteristics%20and%20treatment%20patterns%20of%20patients%20hospitalized%20with%20COVID-19%20by%20race%20and%20ethnicity%20in%20a%20national%20RWD%20during%20the%20early%20months%20of%20the%20pandemic&rft.jtitle=PloS%20one&rft.au=Vititoe,%20Sarah%20E&rft.date=2022-09-26&rft.volume=17&rft.issue=9&rft.spage=e0267815&rft.pages=e0267815-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0267815&rft_dat=%3Cgale_plos_%3EA719694945%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2718126315&rft_id=info:pmid/36155644&rft_galeid=A719694945&rft_doaj_id=oai_doaj_org_article_463a645815e5403e99e5cdf75e581d67&rfr_iscdi=true |