Genome analysis of secondary metabolite‑biosynthetic gene clusters of Photorhabdus akhurstii subsp. akhurstii and its antibacterial activity against antibiotic-resistant bacteria

Xenorhabdus and Photorhabdus can produce a variety of secondary metabolites with broad spectrum bioactivity against microorganisms. We investigated the antibacterial activity of Xenorhabdus and Photorhabdus against 15 antibiotic-resistant bacteria strains. Photorhabdus extracts had strong inhibitory...

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Veröffentlicht in:	PloS one 2022-09, Vol.17 (9), p.e0274956
Hauptverfasser:	Muangpat, Paramaporn, Meesil, Wipanee, Ngoenkam, Jatuporn, Teethaisong, Yothin, Thummeepak, Rapee, Sitthisak, Sutthirat, Tandhavanant, Sarunporn, Chantratita, Narisara, Bode, Helge B, Vitta, Apichat, Thanwisai, Aunchalee
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Antibacterial activity Antibacterial agents Antibiotic resistance Antibiotics Antimicrobial agents Bacteria Biological activity Biology and Life Sciences Cell membranes Cell viability Clusters Drug resistance E coli Gene clusters Genetic aspects Genomes Gram-negative bacteria Health aspects Medicine and Health Sciences Metabolites Methicillin Methicillin resistance Methicillin-Resistant Staphylococcus aureus - genetics Microbial Sensitivity Tests Microorganisms Minimum inhibitory concentration Mortality Multigene Family Nematoda Nematodes Oxacillin Oxacillin - pharmacology Peptides Photorhabdus Photorhabdus - metabolism Plant Extracts - pharmacology Plant metabolites Polyketide synthase Polyketide Synthases - genetics Secondary metabolites Siderophores - metabolism Staphylococcus aureus Staphylococcus aureus - genetics Staphylococcus infections Xenorhabdus Xenorhabdus - genetics
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