The regulon of Brucella abortus two-component system BvrR/BvrS reveals the coordination of metabolic pathways required for intracellular life

Brucella abortus is a facultative intracellular pathogen causing a severe zoonotic disease worldwide. The two-component regulatory system (TCS) BvrR/BvrS of B. abortus is conserved in members of the Alphaproteobacteria class. It is related to the expression of genes required for host interaction and...

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Veröffentlicht in:	PloS one 2022-09, Vol.17 (9), p.e0274397-e0274397
Hauptverfasser:	Rivas-Solano, Olga, Van der Henst, Mathilde, Castillo-Zeledón, Amanda, Suárez-Esquivel, Marcela, Muñoz-Vargas, Lohendy, Capitan-Barrios, Zeuz, Thomson, Nicholas R, Chaves-Olarte, Esteban, Moreno, Edgardo, De Bolle, Xavier, Guzmán-Verri, Caterina
Format:	Artikel
Sprache:	eng
Schlagworte:	Alphaproteobacteria Alternative energy Amino acids Analysis Bacteria Binding sites Biology and Life Sciences Brucella abortus Brucellosis Carbon Care and treatment Cell cycle Cell division Cellular stress response Deoxyribonucleic acid Diagnosis DNA DNA repair Gene expression Gene regulation Genes Genomes Gluconeogenesis Health aspects Homeostasis Infections Intracellular Kinases Maximum likelihood method Medicine and Health Sciences Metabolic pathways Metabolism Nitrogen Nitrogen metabolism Nucleotides Outer membrane proteins Pathways Pentose Pentose phosphate pathway Phosphorylation Proteins Proteomics Recombination Research and Analysis Methods Respiration Signal transduction Synteny Virulence Zoonoses
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