Predictive factors for alpha blocker use after transurethral prostatectomy: Can preoperative urodynamic outcome predict alpha blocker medication after surgery?
To analyze the diagnostic value of conducting urodynamic study (UDS) and show predictors for alpha blocker use 12 months after transurethral prostatectomy. Our study includes 406 participants that had a transurethral prostatectomy at our hospital between 2010 and 2019. All participants took alpha bl...
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| Veröffentlicht in: | PloS one 2022-09, Vol.17 (9), p.e0274399-e0274399 |
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| description | To analyze the diagnostic value of conducting urodynamic study (UDS) and show predictors for alpha blocker use 12 months after transurethral prostatectomy. Our study includes 406 participants that had a transurethral prostatectomy at our hospital between 2010 and 2019. All participants took alpha blockers for more than a month. We collected the participants' preoperative international prostatic symptom score (IPSS), uroflowmetry, transrectal ultrasound, and serum prostatic antigen (PSA) level. A total of 254 patients conducted UDS. After surgery, participants visited our hospital at 1,3,6, and 12 months. 133 patients (32.6%) took alpha blockers continuously for 12 months after surgery. They reported poor preoperative IPSS scores and uroflowmetry outcomes. They also had high postoperative PVR (40.68±24.56 vs 29.34±25.11, p |
| doi_str_mv | 10.1371/journal.pone.0274399 |
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Our study includes 406 participants that had a transurethral prostatectomy at our hospital between 2010 and 2019. All participants took alpha blockers for more than a month. We collected the participants' preoperative international prostatic symptom score (IPSS), uroflowmetry, transrectal ultrasound, and serum prostatic antigen (PSA) level. A total of 254 patients conducted UDS. After surgery, participants visited our hospital at 1,3,6, and 12 months. 133 patients (32.6%) took alpha blockers continuously for 12 months after surgery. They reported poor preoperative IPSS scores and uroflowmetry outcomes. They also had high postoperative PVR (40.68±24.56 vs 29.34±25.11, p<0.001) and total IPSS score (10.35±7.96 vs 8.43±6.74, p = 0.018) compared to the group which discontinued alpha blockers. A multivariate analysis (Table 2) found that conducting preoperative UDS (Odds ratio (OR) 6.067, p75 (OR 2.463, p<0.001), a history of taking 5-alpha reductase inhibitors (5-ARI) before surgery (OR 2.186 [95% CI 1.334-3.583], p = 0.002), IPSS item straining (OR 1.224, p = 0.003), duration of taking alpha blockers [OR 1.009, p = 0.020), and Qmax (OR 0.926, p = 0.018), PVR (OR 1.002, p = 0.022) were confirmed as a strong predictors of persistent alpha blocker use. Conducting preoperative UDS, Age>75, history of taking 5-ARI before surgery, IPSS item straining, duration of alpha blocker medication, Qmax, and PVR are possible determinant factors of alpha blocker use after surgery. By comparing UDS outcomes, detrusor underactivity can be a strong predictor of persisting alpha blocker therapy 12 months after surgery.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0274399</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Adrenergic alpha blockers ; Antigens ; Biology and Life Sciences ; Bladder ; Catheters ; Dosage and administration ; Hypertrophy ; Medicine and Health Sciences ; Multivariate analysis ; Older people ; Patient outcomes ; Patients ; Prostate ; Prostate cancer ; Prostatectomy ; Prostatectomy, Transurethral ; Reductases ; Regression analysis ; Surgery ; Urological surgery</subject><ispartof>PloS one, 2022-09, Vol.17 (9), p.e0274399-e0274399</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Kim et al 2022 Kim et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c669t-928703815439c6531ea6e80c8b347e5a5bd7ab8d28058d6899b61319c75d1fd23</citedby><cites>FETCH-LOGICAL-c669t-928703815439c6531ea6e80c8b347e5a5bd7ab8d28058d6899b61319c75d1fd23</cites><orcidid>0000-0002-4691-6159 ; 0000-0002-8933-6656 ; 0000-0002-0183-5689</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491595/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491595/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79472,79473</link.rule.ids></links><search><contributor>Machado-Alba, Jorge Enrique</contributor><creatorcontrib>Kim, Sung Jin</creatorcontrib><creatorcontrib>Park, Sung Gon</creatorcontrib><creatorcontrib>Pak, Sahyun</creatorcontrib><creatorcontrib>Lee, Young Goo</creatorcontrib><creatorcontrib>Cho, Sung Tae</creatorcontrib><creatorcontrib>Kwon, Ohseong</creatorcontrib><title>Predictive factors for alpha blocker use after transurethral prostatectomy: Can preoperative urodynamic outcome predict alpha blocker medication after surgery?</title><title>PloS one</title><description>To analyze the diagnostic value of conducting urodynamic study (UDS) and show predictors for alpha blocker use 12 months after transurethral prostatectomy. Our study includes 406 participants that had a transurethral prostatectomy at our hospital between 2010 and 2019. All participants took alpha blockers for more than a month. We collected the participants' preoperative international prostatic symptom score (IPSS), uroflowmetry, transrectal ultrasound, and serum prostatic antigen (PSA) level. A total of 254 patients conducted UDS. After surgery, participants visited our hospital at 1,3,6, and 12 months. 133 patients (32.6%) took alpha blockers continuously for 12 months after surgery. They reported poor preoperative IPSS scores and uroflowmetry outcomes. They also had high postoperative PVR (40.68±24.56 vs 29.34±25.11, p<0.001) and total IPSS score (10.35±7.96 vs 8.43±6.74, p = 0.018) compared to the group which discontinued alpha blockers. A multivariate analysis (Table 2) found that conducting preoperative UDS (Odds ratio (OR) 6.067, p75 (OR 2.463, p<0.001), a history of taking 5-alpha reductase inhibitors (5-ARI) before surgery (OR 2.186 [95% CI 1.334-3.583], p = 0.002), IPSS item straining (OR 1.224, p = 0.003), duration of taking alpha blockers [OR 1.009, p = 0.020), and Qmax (OR 0.926, p = 0.018), PVR (OR 1.002, p = 0.022) were confirmed as a strong predictors of persistent alpha blocker use. Conducting preoperative UDS, Age>75, history of taking 5-ARI before surgery, IPSS item straining, duration of alpha blocker medication, Qmax, and PVR are possible determinant factors of alpha blocker use after surgery. By comparing UDS outcomes, detrusor underactivity can be a strong predictor of persisting alpha blocker therapy 12 months after surgery.</description><subject>Adrenergic alpha blockers</subject><subject>Antigens</subject><subject>Biology and Life Sciences</subject><subject>Bladder</subject><subject>Catheters</subject><subject>Dosage and administration</subject><subject>Hypertrophy</subject><subject>Medicine and Health Sciences</subject><subject>Multivariate analysis</subject><subject>Older people</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Prostate</subject><subject>Prostate cancer</subject><subject>Prostatectomy</subject><subject>Prostatectomy, Transurethral</subject><subject>Reductases</subject><subject>Regression analysis</subject><subject>Surgery</subject><subject>Urological 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factors for alpha blocker use after transurethral prostatectomy: Can preoperative urodynamic outcome predict alpha blocker medication after surgery?</title><author>Kim, Sung Jin ; Park, Sung Gon ; Pak, Sahyun ; Lee, Young Goo ; Cho, Sung Tae ; Kwon, Ohseong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c669t-928703815439c6531ea6e80c8b347e5a5bd7ab8d28058d6899b61319c75d1fd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adrenergic alpha blockers</topic><topic>Antigens</topic><topic>Biology and Life Sciences</topic><topic>Bladder</topic><topic>Catheters</topic><topic>Dosage and administration</topic><topic>Hypertrophy</topic><topic>Medicine and Health Sciences</topic><topic>Multivariate analysis</topic><topic>Older people</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Prostate</topic><topic>Prostate cancer</topic><topic>Prostatectomy</topic><topic>Prostatectomy, Transurethral</topic><topic>Reductases</topic><topic>Regression analysis</topic><topic>Surgery</topic><topic>Urological surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Sung Jin</creatorcontrib><creatorcontrib>Park, Sung Gon</creatorcontrib><creatorcontrib>Pak, Sahyun</creatorcontrib><creatorcontrib>Lee, Young Goo</creatorcontrib><creatorcontrib>Cho, Sung Tae</creatorcontrib><creatorcontrib>Kwon, Ohseong</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology 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Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Sung Jin</au><au>Park, Sung Gon</au><au>Pak, Sahyun</au><au>Lee, Young Goo</au><au>Cho, Sung Tae</au><au>Kwon, Ohseong</au><au>Machado-Alba, Jorge Enrique</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive factors for alpha blocker use after transurethral prostatectomy: Can preoperative urodynamic outcome predict alpha blocker medication after surgery?</atitle><jtitle>PloS one</jtitle><date>2022-09-21</date><risdate>2022</risdate><volume>17</volume><issue>9</issue><spage>e0274399</spage><epage>e0274399</epage><pages>e0274399-e0274399</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To analyze the diagnostic value of conducting urodynamic study (UDS) and show predictors for alpha blocker use 12 months after transurethral prostatectomy. Our study includes 406 participants that had a transurethral prostatectomy at our hospital between 2010 and 2019. All participants took alpha blockers for more than a month. We collected the participants' preoperative international prostatic symptom score (IPSS), uroflowmetry, transrectal ultrasound, and serum prostatic antigen (PSA) level. A total of 254 patients conducted UDS. After surgery, participants visited our hospital at 1,3,6, and 12 months. 133 patients (32.6%) took alpha blockers continuously for 12 months after surgery. They reported poor preoperative IPSS scores and uroflowmetry outcomes. They also had high postoperative PVR (40.68±24.56 vs 29.34±25.11, p<0.001) and total IPSS score (10.35±7.96 vs 8.43±6.74, p = 0.018) compared to the group which discontinued alpha blockers. A multivariate analysis (Table 2) found that conducting preoperative UDS (Odds ratio (OR) 6.067, p75 (OR 2.463, p<0.001), a history of taking 5-alpha reductase inhibitors (5-ARI) before surgery (OR 2.186 [95% CI 1.334-3.583], p = 0.002), IPSS item straining (OR 1.224, p = 0.003), duration of taking alpha blockers [OR 1.009, p = 0.020), and Qmax (OR 0.926, p = 0.018), PVR (OR 1.002, p = 0.022) were confirmed as a strong predictors of persistent alpha blocker use. Conducting preoperative UDS, Age>75, history of taking 5-ARI before surgery, IPSS item straining, duration of alpha blocker medication, Qmax, and PVR are possible determinant factors of alpha blocker use after surgery. By comparing UDS outcomes, detrusor underactivity can be a strong predictor of persisting alpha blocker therapy 12 months after surgery.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><doi>10.1371/journal.pone.0274399</doi><tpages>e0274399</tpages><orcidid>https://orcid.org/0000-0002-4691-6159</orcidid><orcidid>https://orcid.org/0000-0002-8933-6656</orcidid><orcidid>https://orcid.org/0000-0002-0183-5689</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adrenergic alpha blockers Antigens Biology and Life Sciences Bladder Catheters Dosage and administration Hypertrophy Medicine and Health Sciences Multivariate analysis Older people Patient outcomes Patients Prostate Prostate cancer Prostatectomy Prostatectomy, Transurethral Reductases Regression analysis Surgery Urological surgery |
| title | Predictive factors for alpha blocker use after transurethral prostatectomy: Can preoperative urodynamic outcome predict alpha blocker medication after surgery? |
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