Localization and functions of native and eGFP-tagged capsid proteins in HIV-1 particles

In infectious HIV-1 particles, the capsid protein (CA) forms a cone-shaped shell called the capsid, which encases the viral ribonucleoprotein complex (vRNP). Following cellular entry, the capsid is disassembled through a poorly understood process referred to as uncoating, which is required to releas...

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Veröffentlicht in:	PLoS pathogens 2022-08, Vol.18 (8), p.e1010754-e1010754
Hauptverfasser:	Francis, Ashwanth C, Cereseto, Anna, Singh, Parmit K, Shi, Jiong, Poeschla, Eric, Engelman, Alan N, Aiken, Christopher, Melikyan, Gregory B
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Biology and Life Sciences Capsid - metabolism Capsid protein Capsid Proteins - genetics Capsid Proteins - metabolism Capsids Chromatin Cytoplasm Experiments Fluorescent indicators Genomes HIV HIV Infections HIV-1 - genetics Human immunodeficiency virus Humans Infections Integrase Labeling Localization Markers Medicine and Health Sciences Nuclear pores Nuclear transport Nuclei (cytology) Physiological aspects Proteins Retention Ribonucleoproteins Structure Uncoating Viral proteins Virion - metabolism Virions Virus Integration Virus Replication Virus Uncoating Viruses
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