Single-cell analysis of Kaposi's sarcoma-associated herpesvirus infection in three-dimensional air-liquid interface culture model

The oral cavity is the major site for transmission of Kaposi's sarcoma-associated herpesvirus (KSHV), but how KSHV establishes infection and replication in the oral epithelia remains unclear. Here, we report a KSHV spontaneous lytic replication model using fully differentiated, three-dimensiona...

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Veröffentlicht in:	PLoS pathogens 2022-08, Vol.18 (8), p.e1010775-e1010775
Hauptverfasser:	Jung, Kyle L, Choi, Un Yung, Park, Angela, Foo, Suan-Sin, Kim, Stephanie, Lee, Shin-Ae, Jung, Jae U
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome Biology and Life Sciences Cell culture Cell death Cell differentiation Development and progression Differentiation Distribution Epithelial cells Epithelium Gene expression Gene Expression Regulation, Viral Gene sequencing Herpesviridae Infections Herpesvirus 8, Human - physiology Humans Infections Kaposi's sarcoma Kaposis sarcoma Keratin Medicine and Health Sciences Oral cavity Organoids Quorum sensing Replication Sarcoma Single-Cell Analysis Virus Latency Virus Replication
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