Development of E-ice-COLD-PCR assay combined with HRM analysis for Nucleophosmin1 gene mutation detection in acute myelogenous leukemia

Mutations of the nucleophosmin1 (NPM1) gene represent the most frequent molecular alteration in acute myelogenous leukemia (AML), especially in patients with AML who have a normal karyotype. These alterations have been shown to carry favorable prognostic significance in patients with AML. Several me...

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Veröffentlicht in:	PloS one 2022-09, Vol.17 (9), p.e0274034-e0274034
Hauptverfasser:	Kongta, Rattana, Panyasit, Noppamas, Jansaento, Wuttichote, Duangmano, Suwit
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Analysis Apoptosis Assaying Biology and Life Sciences Cold Denaturation Deoxyribonucleic acid DNA Engineering and Technology Evaluation Gene mutations Hematology Ice Karyotypes Leukemia Mortality Mutation Patients Point mutation Polymerase chain reaction Research and Analysis Methods
Online-Zugang:	Volltext
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