The effect of acupuncture on oxidative stress: A systematic review and meta-analysis of animal models
Oxidative stress is involved in the occurrence and development of multiple diseases. Acupuncture shows an excellent clinical efficacy in practical application but its mechanism remains unclear. This systematic review and meta-analysis was aimed at assessing the effect of acupuncture on oxidative str...
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| Veröffentlicht in: | PloS one 2022-09, Vol.17 (9), p.e0271098-e0271098 |
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| creator | Zhao, Yu Zhou, Bo Zhang, Guangyin Xu, Shixin Yang, Jipeng Deng, Shizhe Yao, Zengmin Geng, Qiang Ouyang, Bin Xia, Tian |
| description | Oxidative stress is involved in the occurrence and development of multiple diseases. Acupuncture shows an excellent clinical efficacy in practical application but its mechanism remains unclear. This systematic review and meta-analysis was aimed at assessing the effect of acupuncture on oxidative stress in animal models. PubMed, Embase, and Web of Science database were retrieved for randomized controlled trials about acupuncture on oxidative stress in animal models from inception to August 2021. Two reviewers independently screened and extracted articles according to inclusion and exclusion criteria. We used the mean difference (MD)/standardized mean difference (SMD) to perform an effect size analysis and selected fixed-effect or random-effect models to pool the data, depending on a 95% confidence interval (CI). A total of 12 studies comprising 125 samples were included in the quantitative meta-analysis. Compared with sham acupuncture, acupuncture (manual acupuncture, electropuncture, and laser acupuncture) reduced the level of malondialdehyde (SMD, -3.03; CI, -4.40, -1.65; p < 0.00001) and increased the levels of superoxide dismutase (SMD, 3.39; CI, 1.99, 4.79; p < 0.00001), glutathione peroxidase (SMD, 2.21; CI, 1.10, 3.32; p < 0.00001), and catalase (SMD, 2.80; CI, 0.57, 5.03; p = 0.01). This meta-analysis indicated that acupuncture can regulate oxidative stress by lowering the lipid peroxidation and activating the antioxidant enzyme system. In consideration of heterogeneity between studies, future studies should be performed by complying with strict standards and increasing sample size in animal experiments to reduce bias. |
| doi_str_mv | 10.1371/journal.pone.0271098 |
| format | Article |
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Acupuncture shows an excellent clinical efficacy in practical application but its mechanism remains unclear. This systematic review and meta-analysis was aimed at assessing the effect of acupuncture on oxidative stress in animal models. PubMed, Embase, and Web of Science database were retrieved for randomized controlled trials about acupuncture on oxidative stress in animal models from inception to August 2021. Two reviewers independently screened and extracted articles according to inclusion and exclusion criteria. We used the mean difference (MD)/standardized mean difference (SMD) to perform an effect size analysis and selected fixed-effect or random-effect models to pool the data, depending on a 95% confidence interval (CI). A total of 12 studies comprising 125 samples were included in the quantitative meta-analysis. Compared with sham acupuncture, acupuncture (manual acupuncture, electropuncture, and laser acupuncture) reduced the level of malondialdehyde (SMD, -3.03; CI, -4.40, -1.65; p < 0.00001) and increased the levels of superoxide dismutase (SMD, 3.39; CI, 1.99, 4.79; p < 0.00001), glutathione peroxidase (SMD, 2.21; CI, 1.10, 3.32; p < 0.00001), and catalase (SMD, 2.80; CI, 0.57, 5.03; p = 0.01). This meta-analysis indicated that acupuncture can regulate oxidative stress by lowering the lipid peroxidation and activating the antioxidant enzyme system. In consideration of heterogeneity between studies, future studies should be performed by complying with strict standards and increasing sample size in animal experiments to reduce bias.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0271098</identifier><identifier>PMID: 36084019</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Acupuncture ; Alzheimer's disease ; Analysis ; Animal models ; Animal research ; Antioxidants ; Apoptosis ; Bias ; Biology and Life Sciences ; Catalase ; Clinical trials ; DNA damage ; DNA methylation ; Engineering and Technology ; Glutathione ; Glutathione peroxidase ; Heterogeneity ; Influence ; Injuries ; Laboratory animals ; Lasers ; Lipid peroxidation ; Lipids ; Medical research ; Medicine and Health Sciences ; Meta-analysis ; Modelling ; Oxidation ; Oxidative stress ; Peroxidase ; Peroxidation ; Physical Sciences ; Research and Analysis Methods ; Sperm ; Superoxide dismutase ; Systematic review</subject><ispartof>PloS one, 2022-09, Vol.17 (9), p.e0271098-e0271098</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Zhao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Zhao et al 2022 Zhao et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c669t-f8a29d4537e43520f9463b70a50d649ace2033744cc4919a7cd9c464a30eaf893</citedby><cites>FETCH-LOGICAL-c669t-f8a29d4537e43520f9463b70a50d649ace2033744cc4919a7cd9c464a30eaf893</cites><orcidid>0000-0003-3975-155X ; 0000-0001-5285-0064</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462787/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462787/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids></links><search><contributor>Ashraf, Ghulam Md</contributor><creatorcontrib>Zhao, Yu</creatorcontrib><creatorcontrib>Zhou, Bo</creatorcontrib><creatorcontrib>Zhang, Guangyin</creatorcontrib><creatorcontrib>Xu, Shixin</creatorcontrib><creatorcontrib>Yang, Jipeng</creatorcontrib><creatorcontrib>Deng, Shizhe</creatorcontrib><creatorcontrib>Yao, Zengmin</creatorcontrib><creatorcontrib>Geng, Qiang</creatorcontrib><creatorcontrib>Ouyang, Bin</creatorcontrib><creatorcontrib>Xia, Tian</creatorcontrib><title>The effect of acupuncture on oxidative stress: A systematic review and meta-analysis of animal models</title><title>PloS one</title><description>Oxidative stress is involved in the occurrence and development of multiple diseases. Acupuncture shows an excellent clinical efficacy in practical application but its mechanism remains unclear. This systematic review and meta-analysis was aimed at assessing the effect of acupuncture on oxidative stress in animal models. PubMed, Embase, and Web of Science database were retrieved for randomized controlled trials about acupuncture on oxidative stress in animal models from inception to August 2021. Two reviewers independently screened and extracted articles according to inclusion and exclusion criteria. We used the mean difference (MD)/standardized mean difference (SMD) to perform an effect size analysis and selected fixed-effect or random-effect models to pool the data, depending on a 95% confidence interval (CI). A total of 12 studies comprising 125 samples were included in the quantitative meta-analysis. Compared with sham acupuncture, acupuncture (manual acupuncture, electropuncture, and laser acupuncture) reduced the level of malondialdehyde (SMD, -3.03; CI, -4.40, -1.65; p < 0.00001) and increased the levels of superoxide dismutase (SMD, 3.39; CI, 1.99, 4.79; p < 0.00001), glutathione peroxidase (SMD, 2.21; CI, 1.10, 3.32; p < 0.00001), and catalase (SMD, 2.80; CI, 0.57, 5.03; p = 0.01). This meta-analysis indicated that acupuncture can regulate oxidative stress by lowering the lipid peroxidation and activating the antioxidant enzyme system. In consideration of heterogeneity between studies, future studies should be performed by complying with strict standards and increasing sample size in animal experiments to reduce bias.</description><subject>Acupuncture</subject><subject>Alzheimer's disease</subject><subject>Analysis</subject><subject>Animal models</subject><subject>Animal research</subject><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Bias</subject><subject>Biology and Life Sciences</subject><subject>Catalase</subject><subject>Clinical trials</subject><subject>DNA damage</subject><subject>DNA methylation</subject><subject>Engineering and Technology</subject><subject>Glutathione</subject><subject>Glutathione peroxidase</subject><subject>Heterogeneity</subject><subject>Influence</subject><subject>Injuries</subject><subject>Laboratory animals</subject><subject>Lasers</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Modelling</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Peroxidase</subject><subject>Peroxidation</subject><subject>Physical Sciences</subject><subject>Research and Analysis Methods</subject><subject>Sperm</subject><subject>Superoxide dismutase</subject><subject>Systematic 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effect of acupuncture on oxidative stress: A systematic review and meta-analysis of animal models</title><author>Zhao, Yu ; Zhou, Bo ; Zhang, Guangyin ; Xu, Shixin ; Yang, Jipeng ; Deng, Shizhe ; Yao, Zengmin ; Geng, Qiang ; Ouyang, Bin ; Xia, Tian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c669t-f8a29d4537e43520f9463b70a50d649ace2033744cc4919a7cd9c464a30eaf893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acupuncture</topic><topic>Alzheimer's disease</topic><topic>Analysis</topic><topic>Animal models</topic><topic>Animal research</topic><topic>Antioxidants</topic><topic>Apoptosis</topic><topic>Bias</topic><topic>Biology and Life Sciences</topic><topic>Catalase</topic><topic>Clinical trials</topic><topic>DNA damage</topic><topic>DNA methylation</topic><topic>Engineering and Technology</topic><topic>Glutathione</topic><topic>Glutathione 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Md</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of acupuncture on oxidative stress: A systematic review and meta-analysis of animal models</atitle><jtitle>PloS one</jtitle><date>2022-09-09</date><risdate>2022</risdate><volume>17</volume><issue>9</issue><spage>e0271098</spage><epage>e0271098</epage><pages>e0271098-e0271098</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Oxidative stress is involved in the occurrence and development of multiple diseases. Acupuncture shows an excellent clinical efficacy in practical application but its mechanism remains unclear. This systematic review and meta-analysis was aimed at assessing the effect of acupuncture on oxidative stress in animal models. PubMed, Embase, and Web of Science database were retrieved for randomized controlled trials about acupuncture on oxidative stress in animal models from inception to August 2021. Two reviewers independently screened and extracted articles according to inclusion and exclusion criteria. We used the mean difference (MD)/standardized mean difference (SMD) to perform an effect size analysis and selected fixed-effect or random-effect models to pool the data, depending on a 95% confidence interval (CI). A total of 12 studies comprising 125 samples were included in the quantitative meta-analysis. Compared with sham acupuncture, acupuncture (manual acupuncture, electropuncture, and laser acupuncture) reduced the level of malondialdehyde (SMD, -3.03; CI, -4.40, -1.65; p < 0.00001) and increased the levels of superoxide dismutase (SMD, 3.39; CI, 1.99, 4.79; p < 0.00001), glutathione peroxidase (SMD, 2.21; CI, 1.10, 3.32; p < 0.00001), and catalase (SMD, 2.80; CI, 0.57, 5.03; p = 0.01). This meta-analysis indicated that acupuncture can regulate oxidative stress by lowering the lipid peroxidation and activating the antioxidant enzyme system. In consideration of heterogeneity between studies, future studies should be performed by complying with strict standards and increasing sample size in animal experiments to reduce bias.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>36084019</pmid><doi>10.1371/journal.pone.0271098</doi><tpages>e0271098</tpages><orcidid>https://orcid.org/0000-0003-3975-155X</orcidid><orcidid>https://orcid.org/0000-0001-5285-0064</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acupuncture Alzheimer's disease Analysis Animal models Animal research Antioxidants Apoptosis Bias Biology and Life Sciences Catalase Clinical trials DNA damage DNA methylation Engineering and Technology Glutathione Glutathione peroxidase Heterogeneity Influence Injuries Laboratory animals Lasers Lipid peroxidation Lipids Medical research Medicine and Health Sciences Meta-analysis Modelling Oxidation Oxidative stress Peroxidase Peroxidation Physical Sciences Research and Analysis Methods Sperm Superoxide dismutase Systematic review |
| title | The effect of acupuncture on oxidative stress: A systematic review and meta-analysis of animal models |
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