In silico analysis and in planta production of recombinant ccl21/IL1β protein and characterization of its in vitro anti-tumor and immunogenic activity

CCL21 has an essential role in anti-tumor immune activity. Epitopes of IL1β have adjuvant activity without causing inflammatory responses. CCR7 and its ligands play a vital role in the immune balance; specifically, in transport of T lymphocytes and antigen-presenting cells such as dendritic cells to...

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Veröffentlicht in:	PloS one 2022-08, Vol.17 (8), p.e0261101
Hauptverfasser:	Marashi, Hasan, Beihaghi, Maria, Chaboksavar, Masoud, Khaksar, Samad, Tehrani, Homan, Abiri, Ardavan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Anticancer properties Antigen-presenting cells Antigens Binding sites Biological activity Biology and Life Sciences Breast cancer Cancer CC chemokine receptors CCL21 protein CCR7 protein Cell Movement Chemokine CCL21 - genetics Chemokine CCL21 - metabolism Chemokines Computer simulation Cytokines Dendritic cells Engineering and Technology Epitopes Gene expression Genomes Humans IL-1β Immunogenicity In vivo methods and tests Inflammation Leukocyte migration Ligands Lymph nodes Lymphocytes Lymphocytes T Medical research Medicine and Health Sciences Neutrophils Peptides Protein structure Proteins Receptors, CCR7 - genetics Receptors, CCR7 - metabolism Recombinant Proteins - genetics Research and Analysis Methods Servers Structure-function relationships Survival T-Lymphocytes - metabolism Tobacco Tumors Western blotting Wound healing
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