Chemical and enzymatic modifications of 5-methylcytosine at the intersection of DNA damage, repair, and epigenetic reprogramming

The DNA of all living organisms is persistently damaged by endogenous reactions including deamination and oxidation. Such damage, if not repaired correctly, can result in mutations that drive tumor development. In addition to chemical damage, recent studies have established that DNA bases can be enz...

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Veröffentlicht in:	PloS one 2022-08, Vol.17 (8), p.e0273509
Hauptverfasser:	Baljinnyam, Tuvshintugs, Sowers, Mark L, Hsu, Chia Wei, Conrad, James W, Herring, Jason L, Hackfeld, Linda C, Sowers, Lawrence C
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methylcytosine - metabolism Analysis Biology and Life Sciences Chemical damage Deamination Deoxyribonucleic acid DNA DNA - genetics DNA Damage DNA methylation DNA Repair Enzymes Epigenesis, Genetic Epigenetic inheritance Epigenetics Genes Genetic transcription Humans Intersections Mutation Oligonucleotides Oxidation Physical Sciences Potassium Protein expression Protein interaction Proteins Repair SMUG1 protein Substrates Thymine DNA Glycosylase - chemistry Thymine DNA Glycosylase - genetics Thymine DNA Glycosylase - metabolism Tumors
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