Triple-negative breast cancer influences a mixed M1/M2 macrophage phenotype associated with tumor aggressiveness

Triple-negative breast cancer (TNBC) is characterized by excessive accumulation of tumor-infiltrating immune cells, including tumor-associated macrophages (TAMs). TAMs consist of a heterogeneous population with high plasticity and are associated with tumor aggressiveness and poor prognosis. Moreover...

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Veröffentlicht in:	PloS one 2022-08, Vol.17 (8), p.e0273044-e0273044
Hauptverfasser:	Pe, Kristine Cate S, Saetung, Rattana, Yodsurang, Varalee, Chaotham, Chatchai, Suppipat, Koramit, Chanvorachote, Pithi, Tawinwung, Supannikar
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and Life Sciences Breast cancer Cell growth Chemokines Crosstalk CXCL10 protein Cytokines Development and progression Diagnosis Flow cytometry Gene expression Genes Genotype & phenotype Growth factors Health aspects IL-1β Immune system Inflammation Interleukin 10 Interleukin 6 Macrophages Medical prognosis Medicine and Health Sciences Phenotypes Polarization Polymerase chain reaction Survival analysis Tumor necrosis factor-TNF Tumor-infiltrating lymphocytes
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