Triple-negative breast cancer influences a mixed M1/M2 macrophage phenotype associated with tumor aggressiveness
Triple-negative breast cancer (TNBC) is characterized by excessive accumulation of tumor-infiltrating immune cells, including tumor-associated macrophages (TAMs). TAMs consist of a heterogeneous population with high plasticity and are associated with tumor aggressiveness and poor prognosis. Moreover...
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| description | Triple-negative breast cancer (TNBC) is characterized by excessive accumulation of tumor-infiltrating immune cells, including tumor-associated macrophages (TAMs). TAMs consist of a heterogeneous population with high plasticity and are associated with tumor aggressiveness and poor prognosis. Moreover, breast cancer cells can secrete factors that influence TAM polarization. Therefore, this study aimed to evaluate the crosstalk between cancer cells and macrophages in the context of TNBC. Cytokine-polarized M2 macrophage were used as control. Distinct from the classical M2 macrophage, TAMs generated from TNBC-conditioned media upregulated both M1- and M2-associated genes, and secreted both the anti-inflammatory cytokine interleukin IL-10 and the proinflammatory cytokine IL-6 and tumor necrosis factor- [alpha]. Theses TNBC-induced TAMs exert aggressive behavior of TNBC cells. Consistently, TCGA and MTABRIC analyses of human breast cancer revealed upregulation of M1- associated genes in TNBC comparing with non-TNBC. Among these M1-associated genes, CXCL10 and IL1B were revealed to be independent prognostic factors for disease progression. In conclusion, TNBC cells induce macrophage polarization with a mixture of M1 and M2 phenotypes. These cancer-induced TAMs further enhance tumor cell growth and aggressiveness. |
| doi_str_mv | 10.1371/journal.pone.0273044 |
| format | Article |
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TAMs consist of a heterogeneous population with high plasticity and are associated with tumor aggressiveness and poor prognosis. Moreover, breast cancer cells can secrete factors that influence TAM polarization. Therefore, this study aimed to evaluate the crosstalk between cancer cells and macrophages in the context of TNBC. Cytokine-polarized M2 macrophage were used as control. Distinct from the classical M2 macrophage, TAMs generated from TNBC-conditioned media upregulated both M1- and M2-associated genes, and secreted both the anti-inflammatory cytokine interleukin IL-10 and the proinflammatory cytokine IL-6 and tumor necrosis factor- [alpha]. Theses TNBC-induced TAMs exert aggressive behavior of TNBC cells. Consistently, TCGA and MTABRIC analyses of human breast cancer revealed upregulation of M1- associated genes in TNBC comparing with non-TNBC. Among these M1-associated genes, CXCL10 and IL1B were revealed to be independent prognostic factors for disease progression. In conclusion, TNBC cells induce macrophage polarization with a mixture of M1 and M2 phenotypes. These cancer-induced TAMs further enhance tumor cell growth and aggressiveness.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0273044</identifier><identifier>PMID: 35960749</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Biology and Life Sciences ; Breast cancer ; Cell growth ; Chemokines ; Crosstalk ; CXCL10 protein ; Cytokines ; Development and progression ; Diagnosis ; Flow cytometry ; Gene expression ; Genes ; Genotype & phenotype ; Growth factors ; Health aspects ; IL-1β ; Immune system ; Inflammation ; Interleukin 10 ; Interleukin 6 ; Macrophages ; Medical prognosis ; Medicine and Health Sciences ; Phenotypes ; Polarization ; Polymerase chain reaction ; Survival analysis ; Tumor necrosis factor-TNF ; Tumor-infiltrating lymphocytes</subject><ispartof>PloS one, 2022-08, Vol.17 (8), p.e0273044-e0273044</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Pe et al. 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TAMs consist of a heterogeneous population with high plasticity and are associated with tumor aggressiveness and poor prognosis. Moreover, breast cancer cells can secrete factors that influence TAM polarization. Therefore, this study aimed to evaluate the crosstalk between cancer cells and macrophages in the context of TNBC. Cytokine-polarized M2 macrophage were used as control. Distinct from the classical M2 macrophage, TAMs generated from TNBC-conditioned media upregulated both M1- and M2-associated genes, and secreted both the anti-inflammatory cytokine interleukin IL-10 and the proinflammatory cytokine IL-6 and tumor necrosis factor- [alpha]. Theses TNBC-induced TAMs exert aggressive behavior of TNBC cells. Consistently, TCGA and MTABRIC analyses of human breast cancer revealed upregulation of M1- associated genes in TNBC comparing with non-TNBC. Among these M1-associated genes, CXCL10 and IL1B were revealed to be independent prognostic factors for disease progression. In conclusion, TNBC cells induce macrophage polarization with a mixture of M1 and M2 phenotypes. 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one</jtitle><date>2022-08-12</date><risdate>2022</risdate><volume>17</volume><issue>8</issue><spage>e0273044</spage><epage>e0273044</epage><pages>e0273044-e0273044</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Triple-negative breast cancer (TNBC) is characterized by excessive accumulation of tumor-infiltrating immune cells, including tumor-associated macrophages (TAMs). TAMs consist of a heterogeneous population with high plasticity and are associated with tumor aggressiveness and poor prognosis. Moreover, breast cancer cells can secrete factors that influence TAM polarization. Therefore, this study aimed to evaluate the crosstalk between cancer cells and macrophages in the context of TNBC. Cytokine-polarized M2 macrophage were used as control. Distinct from the classical M2 macrophage, TAMs generated from TNBC-conditioned media upregulated both M1- and M2-associated genes, and secreted both the anti-inflammatory cytokine interleukin IL-10 and the proinflammatory cytokine IL-6 and tumor necrosis factor- [alpha]. Theses TNBC-induced TAMs exert aggressive behavior of TNBC cells. Consistently, TCGA and MTABRIC analyses of human breast cancer revealed upregulation of M1- associated genes in TNBC comparing with non-TNBC. Among these M1-associated genes, CXCL10 and IL1B were revealed to be independent prognostic factors for disease progression. In conclusion, TNBC cells induce macrophage polarization with a mixture of M1 and M2 phenotypes. These cancer-induced TAMs further enhance tumor cell growth and aggressiveness.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>35960749</pmid><doi>10.1371/journal.pone.0273044</doi><tpages>e0273044</tpages><orcidid>https://orcid.org/0000-0003-2151-4580</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biology and Life Sciences Breast cancer Cell growth Chemokines Crosstalk CXCL10 protein Cytokines Development and progression Diagnosis Flow cytometry Gene expression Genes Genotype & phenotype Growth factors Health aspects IL-1β Immune system Inflammation Interleukin 10 Interleukin 6 Macrophages Medical prognosis Medicine and Health Sciences Phenotypes Polarization Polymerase chain reaction Survival analysis Tumor necrosis factor-TNF Tumor-infiltrating lymphocytes |
| title | Triple-negative breast cancer influences a mixed M1/M2 macrophage phenotype associated with tumor aggressiveness |
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