Development of an observational exposure human biomonitoring study to assess Canadian children's DEET exposure during protective use
Biomonitoring data of N,N-diethyl-meta-toluamide (DEET) in children is scarce and limited to controlled exposure and surveillance studies. We conducted a 24-hour observational exposure and human biomonitoring study designed to estimate use of and exposure to DEET-based insect repellents by Canadian...
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| Veröffentlicht in: | PloS one 2022-08, Vol.17 (8), p.e0268341 |
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| creator | Gibson, Jennifer C Marro, Leonora Borghese, Michael M Brandow, Danielle Remedios, Lauren Fisher, Mandy Malowany, Morie Kieliszkiewicz, Katarzyna Lukina, Anna O Irwin, Kim |
| description | Biomonitoring data of N,N-diethyl-meta-toluamide (DEET) in children is scarce and limited to controlled exposure and surveillance studies. We conducted a 24-hour observational exposure and human biomonitoring study designed to estimate use of and exposure to DEET-based insect repellents by Canadian children in an overnight summer camp setting. Here, we present our study design and methodology. In 2019, children between the ages of 7 and 13 took part in the study (n = 126). Children controlled their use of DEET-based insect repellents, and provided an account of their activities at camp that could impact insect repellent absorption. Children provided a total of 389 urine samples throughout the study day, and reported the time that they applied insect repellent, which allowed us to contextualize urinary DEET and metabolite concentrations with respect to the timing of insect repellent application. DEET (2.3% |
| doi_str_mv | 10.1371/journal.pone.0268341 |
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We conducted a 24-hour observational exposure and human biomonitoring study designed to estimate use of and exposure to DEET-based insect repellents by Canadian children in an overnight summer camp setting. Here, we present our study design and methodology. In 2019, children between the ages of 7 and 13 took part in the study (n = 126). Children controlled their use of DEET-based insect repellents, and provided an account of their activities at camp that could impact insect repellent absorption. Children provided a total of 389 urine samples throughout the study day, and reported the time that they applied insect repellent, which allowed us to contextualize urinary DEET and metabolite concentrations with respect to the timing of insect repellent application. DEET (2.3% <Limits of detection (LOD)) and two metabolites, N,N-diethyl-m-(hydroxymethyl)benzamide (DHMB) (0% <LOD) and 3-diethylcarbamoyl benzoic acid (DCBA) (0% <LOD), were measured in urine samples. Three time difference scenarios were established for the data and analysed to account for these complex time-dependent data, which demonstrated the need for DEET biomonitoring to be done in context with the timing of a known DEET exposure or over the course of at least 14 to 24 hours to better capture the excretion curve. To our knowledge, this is the first field-based study of real-world exposure to DEET in children. Our experience and results suggest that this type of real-world observational exposure study with a human biomonitoring component can generate data reflective of actual exposure, but is not without significant logistic, practical, and analytical challenges.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0268341</identifier><identifier>PMID: 35925987</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Age ; Benzamide ; Benzoic acid ; Biological Monitoring ; Biology and Life Sciences ; Biomonitoring ; Camps ; Canada ; Child ; Children ; Consent ; Contraindications ; Data collection ; DEET ; Evaluation ; Exposure ; Health aspects ; Humans ; Insect Repellents ; Insecticides ; Insects ; Medicine and Health Sciences ; Metabolites ; Packaging ; People and Places ; Physical Sciences ; Population ; Quality control ; Questionnaires ; Repellents ; Research and Analysis Methods ; Skin ; Time dependence ; Urine ; West Nile virus</subject><ispartof>PloS one, 2022-08, Vol.17 (8), p.e0268341</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Health Canada and Gibson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Health Canada and Gibson et al 2022 Health Canada and Gibson et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-6c1b20977e24e7925776bfc04e0038a93fbf8d14fe3a0a2cada2952d427724123</citedby><cites>FETCH-LOGICAL-c692t-6c1b20977e24e7925776bfc04e0038a93fbf8d14fe3a0a2cada2952d427724123</cites><orcidid>0000-0002-7351-522X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352095/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352095/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35925987$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Vieira, José Luiz Fernandes</contributor><creatorcontrib>Gibson, Jennifer C</creatorcontrib><creatorcontrib>Marro, Leonora</creatorcontrib><creatorcontrib>Borghese, Michael M</creatorcontrib><creatorcontrib>Brandow, Danielle</creatorcontrib><creatorcontrib>Remedios, Lauren</creatorcontrib><creatorcontrib>Fisher, Mandy</creatorcontrib><creatorcontrib>Malowany, Morie</creatorcontrib><creatorcontrib>Kieliszkiewicz, Katarzyna</creatorcontrib><creatorcontrib>Lukina, Anna O</creatorcontrib><creatorcontrib>Irwin, Kim</creatorcontrib><title>Development of an observational exposure human biomonitoring study to assess Canadian children's DEET exposure during protective use</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Biomonitoring data of N,N-diethyl-meta-toluamide (DEET) in children is scarce and limited to controlled exposure and surveillance studies. 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Three time difference scenarios were established for the data and analysed to account for these complex time-dependent data, which demonstrated the need for DEET biomonitoring to be done in context with the timing of a known DEET exposure or over the course of at least 14 to 24 hours to better capture the excretion curve. To our knowledge, this is the first field-based study of real-world exposure to DEET in children. Our experience and results suggest that this type of real-world observational exposure study with a human biomonitoring component can generate data reflective of actual exposure, but is not without significant logistic, practical, and analytical challenges.</description><subject>Adolescent</subject><subject>Age</subject><subject>Benzamide</subject><subject>Benzoic acid</subject><subject>Biological Monitoring</subject><subject>Biology and Life Sciences</subject><subject>Biomonitoring</subject><subject>Camps</subject><subject>Canada</subject><subject>Child</subject><subject>Children</subject><subject>Consent</subject><subject>Contraindications</subject><subject>Data collection</subject><subject>DEET</subject><subject>Evaluation</subject><subject>Exposure</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Insect Repellents</subject><subject>Insecticides</subject><subject>Insects</subject><subject>Medicine and Health 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of an observational exposure human biomonitoring study to assess Canadian children's DEET exposure during protective use</title><author>Gibson, Jennifer C ; Marro, Leonora ; Borghese, Michael M ; Brandow, Danielle ; Remedios, Lauren ; Fisher, Mandy ; Malowany, Morie ; Kieliszkiewicz, Katarzyna ; Lukina, Anna O ; Irwin, Kim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-6c1b20977e24e7925776bfc04e0038a93fbf8d14fe3a0a2cada2952d427724123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adolescent</topic><topic>Age</topic><topic>Benzamide</topic><topic>Benzoic acid</topic><topic>Biological Monitoring</topic><topic>Biology and Life Sciences</topic><topic>Biomonitoring</topic><topic>Camps</topic><topic>Canada</topic><topic>Child</topic><topic>Children</topic><topic>Consent</topic><topic>Contraindications</topic><topic>Data 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We conducted a 24-hour observational exposure and human biomonitoring study designed to estimate use of and exposure to DEET-based insect repellents by Canadian children in an overnight summer camp setting. Here, we present our study design and methodology. In 2019, children between the ages of 7 and 13 took part in the study (n = 126). Children controlled their use of DEET-based insect repellents, and provided an account of their activities at camp that could impact insect repellent absorption. Children provided a total of 389 urine samples throughout the study day, and reported the time that they applied insect repellent, which allowed us to contextualize urinary DEET and metabolite concentrations with respect to the timing of insect repellent application. DEET (2.3% <Limits of detection (LOD)) and two metabolites, N,N-diethyl-m-(hydroxymethyl)benzamide (DHMB) (0% <LOD) and 3-diethylcarbamoyl benzoic acid (DCBA) (0% <LOD), were measured in urine samples. Three time difference scenarios were established for the data and analysed to account for these complex time-dependent data, which demonstrated the need for DEET biomonitoring to be done in context with the timing of a known DEET exposure or over the course of at least 14 to 24 hours to better capture the excretion curve. To our knowledge, this is the first field-based study of real-world exposure to DEET in children. Our experience and results suggest that this type of real-world observational exposure study with a human biomonitoring component can generate data reflective of actual exposure, but is not without significant logistic, practical, and analytical challenges.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>35925987</pmid><doi>10.1371/journal.pone.0268341</doi><tpages>e0268341</tpages><orcidid>https://orcid.org/0000-0002-7351-522X</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2022-08, Vol.17 (8), p.e0268341 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2698609489 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Age Benzamide Benzoic acid Biological Monitoring Biology and Life Sciences Biomonitoring Camps Canada Child Children Consent Contraindications Data collection DEET Evaluation Exposure Health aspects Humans Insect Repellents Insecticides Insects Medicine and Health Sciences Metabolites Packaging People and Places Physical Sciences Population Quality control Questionnaires Repellents Research and Analysis Methods Skin Time dependence Urine West Nile virus |
| title | Development of an observational exposure human biomonitoring study to assess Canadian children's DEET exposure during protective use |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T23%3A37%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Development%20of%20an%20observational%20exposure%20human%20biomonitoring%20study%20to%20assess%20Canadian%20children's%20DEET%20exposure%20during%20protective%20use&rft.jtitle=PloS%20one&rft.au=Gibson,%20Jennifer%20C&rft.date=2022-08-04&rft.volume=17&rft.issue=8&rft.spage=e0268341&rft.pages=e0268341-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0268341&rft_dat=%3Cgale_plos_%3EA712539760%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2698609489&rft_id=info:pmid/35925987&rft_galeid=A712539760&rft_doaj_id=oai_doaj_org_article_6c9ea261544e4398a26377d28d0b8a9d&rfr_iscdi=true |