Pyrylium based derivatization imaging mass spectrometer revealed the localization of L-DOPA

Simultaneous imaging of l-dihydroxyphenylalanine (l-DOPA), dopamine (DA) and norepinephrine (NE) in the catecholamine metabolic pathway is particularly useful because l-DOPA is a neurophysiologically important metabolic intermediate. In this study, we found that 2,4,6-trimethylpyrillium tetrafluorob...

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Veröffentlicht in:	PloS one 2022-08, Vol.17 (8), p.e0271697-e0271697
Hauptverfasser:	Taira, Shu, Ikeda, Akari, Sugiura, Yuki, Shikano, Hitomi, Kobayashi, Shoko, Terauchi, Tsutomu, Yokoyama, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biology and Life Sciences Brain Brain stem Catecholamine Catecholamines Chromatography Deuteration Dihydroxyphenylalanine Dopamine Dopamine D3 receptors Evaluation Gene expression Hydroxylase Imaging Laboratory animals Lasers Levodopa Localization Locus coeruleus Mass spectrometry Mass spectroscopy Medicine and Health Sciences Metabolic pathways Metabolism Metabolites Monoamines Neostriatum Neuroimaging Neurotransmitters Norepinephrine Physical Sciences Reagents Research and Analysis Methods Signal transduction Tyrosine Tyrosine 3-monooxygenase
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