Characteristics of colorectal cancer and use of colonoscopy before colorectal cancer diagnosis among individuals with inflammatory bowel disease: A population-based study
There are limited recent data on the characteristics of inflammatory bowel disease (IBD)-associated colorectal cancer (CRC) and the use of colonoscopy prior to CRC diagnosis among persons with IBD. We analyzed IBD-CRC characteristics, survival after IBD-CRC diagnosis and the use of colonoscopy prior...
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| Veröffentlicht in: | PloS one 2022-08, Vol.17 (8), p.e0272158-e0272158 |
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| description | There are limited recent data on the characteristics of inflammatory bowel disease (IBD)-associated colorectal cancer (CRC) and the use of colonoscopy prior to CRC diagnosis among persons with IBD. We analyzed IBD-CRC characteristics, survival after IBD-CRC diagnosis and the use of colonoscopy prior to IBD-CRC diagnosis over time. We identified individuals with and without IBD from the University of Manitoba IBD Epidemiology Database and CRC from linkage to the Manitoba Cancer Registry. We compared characteristics of IBD-CRC and sporadic-CRC using logistic regression and survival after CRC diagnosis using Cox regression analysis. We assessed rate and predictors of colonoscopy use 5 years to 6 months prior to IBD-CRC. 1,262 individuals with CRC were included (212 IBD-CRC). IBD was associated with an increased risk of death after CRC diagnosis in 2004-2011 (HR 1.89; 95% CI 1.25-2.88) but not in 2012-2017 (HR = 1.002; CI 0.50-2.03). In the 5 years to 6 months prior to IBD-CRC (1989-2018), 51% underwent colonoscopy, which was very similar to IBD without CRC and contrasted to 9% among sporadic CRCs. Exposure to colonoscopy pre IBD-CRC remained stable through the study period (1989-2002 OR = 1.25; CI 0.77-2.01; 2003-2011 OR = 1.21; CI 0.56-1.70; reference 2012-2018). Exposure to colonoscopy pre-IBD-CRC was not associated with improved post-CRC survival. The risk of death following CRC diagnosis is not impacted by a diagnosis of IBD in recent years. There is a very high proportion of post colonoscopy CRC among IBD-CRC, which has not changed over the years and needs detailed root-cause analysis and interventions. |
| doi_str_mv | 10.1371/journal.pone.0272158 |
| format | Article |
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IBD was associated with an increased risk of death after CRC diagnosis in 2004-2011 (HR 1.89; 95% CI 1.25-2.88) but not in 2012-2017 (HR = 1.002; CI 0.50-2.03). In the 5 years to 6 months prior to IBD-CRC (1989-2018), 51% underwent colonoscopy, which was very similar to IBD without CRC and contrasted to 9% among sporadic CRCs. Exposure to colonoscopy pre IBD-CRC remained stable through the study period (1989-2002 OR = 1.25; CI 0.77-2.01; 2003-2011 OR = 1.21; CI 0.56-1.70; reference 2012-2018). Exposure to colonoscopy pre-IBD-CRC was not associated with improved post-CRC survival. The risk of death following CRC diagnosis is not impacted by a diagnosis of IBD in recent years. There is a very high proportion of post colonoscopy CRC among IBD-CRC, which has not changed over the years and needs detailed root-cause analysis and interventions.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0272158</identifier><identifier>PMID: 35913956</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Ambulatory care ; Biology and Life Sciences ; Cancer ; Colonoscopy ; Colorectal cancer ; Colorectal carcinoma ; Comorbidity ; Complications and side effects ; Crohn's disease ; Diagnosis ; Epidemiology ; Evaluation ; Health insurance ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Intestine ; Medical diagnosis ; Medicine and Health Sciences ; People and places ; Personal health ; Pharmaceuticals ; Population ; Population studies ; Population-based studies ; Regression analysis ; Root cause analysis ; Socioeconomic factors ; Survival</subject><ispartof>PloS one, 2022-08, Vol.17 (8), p.e0272158-e0272158</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Hansen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Jewel</creatorcontrib><creatorcontrib>Murthy, Sanjay K</creatorcontrib><creatorcontrib>Singh, Harminder</creatorcontrib><title>Characteristics of colorectal cancer and use of colonoscopy before colorectal cancer diagnosis among individuals with inflammatory bowel disease: A population-based study</title><title>PloS one</title><description>There are limited recent data on the characteristics of inflammatory bowel disease (IBD)-associated colorectal cancer (CRC) and the use of colonoscopy prior to CRC diagnosis among persons with IBD. We analyzed IBD-CRC characteristics, survival after IBD-CRC diagnosis and the use of colonoscopy prior to IBD-CRC diagnosis over time. We identified individuals with and without IBD from the University of Manitoba IBD Epidemiology Database and CRC from linkage to the Manitoba Cancer Registry. We compared characteristics of IBD-CRC and sporadic-CRC using logistic regression and survival after CRC diagnosis using Cox regression analysis. We assessed rate and predictors of colonoscopy use 5 years to 6 months prior to IBD-CRC. 1,262 individuals with CRC were included (212 IBD-CRC). IBD was associated with an increased risk of death after CRC diagnosis in 2004-2011 (HR 1.89; 95% CI 1.25-2.88) but not in 2012-2017 (HR = 1.002; CI 0.50-2.03). In the 5 years to 6 months prior to IBD-CRC (1989-2018), 51% underwent colonoscopy, which was very similar to IBD without CRC and contrasted to 9% among sporadic CRCs. Exposure to colonoscopy pre IBD-CRC remained stable through the study period (1989-2002 OR = 1.25; CI 0.77-2.01; 2003-2011 OR = 1.21; CI 0.56-1.70; reference 2012-2018). Exposure to colonoscopy pre-IBD-CRC was not associated with improved post-CRC survival. The risk of death following CRC diagnosis is not impacted by a diagnosis of IBD in recent years. 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Jewel</au><au>Murthy, Sanjay K</au><au>Singh, Harminder</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristics of colorectal cancer and use of colonoscopy before colorectal cancer diagnosis among individuals with inflammatory bowel disease: A population-based study</atitle><jtitle>PloS one</jtitle><date>2022-08-01</date><risdate>2022</risdate><volume>17</volume><issue>8</issue><spage>e0272158</spage><epage>e0272158</epage><pages>e0272158-e0272158</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>There are limited recent data on the characteristics of inflammatory bowel disease (IBD)-associated colorectal cancer (CRC) and the use of colonoscopy prior to CRC diagnosis among persons with IBD. We analyzed IBD-CRC characteristics, survival after IBD-CRC diagnosis and the use of colonoscopy prior to IBD-CRC diagnosis over time. We identified individuals with and without IBD from the University of Manitoba IBD Epidemiology Database and CRC from linkage to the Manitoba Cancer Registry. We compared characteristics of IBD-CRC and sporadic-CRC using logistic regression and survival after CRC diagnosis using Cox regression analysis. We assessed rate and predictors of colonoscopy use 5 years to 6 months prior to IBD-CRC. 1,262 individuals with CRC were included (212 IBD-CRC). IBD was associated with an increased risk of death after CRC diagnosis in 2004-2011 (HR 1.89; 95% CI 1.25-2.88) but not in 2012-2017 (HR = 1.002; CI 0.50-2.03). In the 5 years to 6 months prior to IBD-CRC (1989-2018), 51% underwent colonoscopy, which was very similar to IBD without CRC and contrasted to 9% among sporadic CRCs. Exposure to colonoscopy pre IBD-CRC remained stable through the study period (1989-2002 OR = 1.25; CI 0.77-2.01; 2003-2011 OR = 1.21; CI 0.56-1.70; reference 2012-2018). Exposure to colonoscopy pre-IBD-CRC was not associated with improved post-CRC survival. The risk of death following CRC diagnosis is not impacted by a diagnosis of IBD in recent years. There is a very high proportion of post colonoscopy CRC among IBD-CRC, which has not changed over the years and needs detailed root-cause analysis and interventions.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>35913956</pmid><doi>10.1371/journal.pone.0272158</doi><tpages>e0272158</tpages><orcidid>https://orcid.org/0000-0002-9354-2356</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Ambulatory care Biology and Life Sciences Cancer Colonoscopy Colorectal cancer Colorectal carcinoma Comorbidity Complications and side effects Crohn's disease Diagnosis Epidemiology Evaluation Health insurance Inflammatory bowel disease Inflammatory bowel diseases Intestine Medical diagnosis Medicine and Health Sciences People and places Personal health Pharmaceuticals Population Population studies Population-based studies Regression analysis Root cause analysis Socioeconomic factors Survival |
| title | Characteristics of colorectal cancer and use of colonoscopy before colorectal cancer diagnosis among individuals with inflammatory bowel disease: A population-based study |
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