Chemical evidence for the tradeoff-in-the-nephron hypothesis to explain secondary hyperparathyroidism

Secondary hyperparathyroidism (SHPT) complicates advanced chronic kidney disease (CKD) and causes skeletal and other morbidity. In animal models of CKD, SHPT was prevented and reversed by reduction of dietary phosphate in proportion to GFR, but the phenomena underlying these observations are not und...

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Veröffentlicht in:	PloS one 2022-08, Vol.17 (8), p.e0272380-e0272380
Hauptverfasser:	Phelps, Kenneth R, Gemoets, Darren E, May, Peter M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Biology and Life Sciences Calcium content Calcium phosphates Chemical precipitation Chemical speciation Creatinine Diagnosis Diet Epidermal growth factor receptors Evaluation Filtrate Glomerular filtration rate Health aspects Hyperparathyroidism Hypotheses Kidney diseases Laboratories Medicine and Health Sciences Morbidity Parathyroid hormone Patients pH effects Phosphaturia Phosphorus Physical Sciences Precipitation Reabsorption Reduction Risk factors Solid phases Speciation Tradeoffs Tricalcium phosphate Urine
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