Parainfluenza virus infections in patients with hematological malignancies or stem cell transplantation: Analysis of clinical characteristics, nosocomial transmission and viral shedding
To assess morbidity and mortality of parainfluenza virus (PIV) infections in immunocompromised patients, we analysed PIV infections in a hematology and stem cell transplantation (SCT) unit over the course of three years. Isolated PIV strains were characterized by sequence analysis and nosocomial tra...
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| Veröffentlicht in: | PloS one 2022-07, Vol.17 (7), p.e0271756-e0271756 |
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| creator | Tabatabai, Julia Schnitzler, Paul Prifert, Christiane Schiller, Martin Weissbrich, Benedikt von Lilienfeld-Toal, Marie Teschner, Daniel Jordan, Karin Müller-Tidow, Carsten Egerer, Gerlinde Giesen, Nicola |
| description | To assess morbidity and mortality of parainfluenza virus (PIV) infections in immunocompromised patients, we analysed PIV infections in a hematology and stem cell transplantation (SCT) unit over the course of three years. Isolated PIV strains were characterized by sequence analysis and nosocomial transmission was assessed including phylogenetic analysis of viral strains. 109 cases of PIV infection were identified, 75 in the setting of SCT. PIV type 3 (n = 68) was the most frequent subtype. PIV lower respiratory tract infection (LRTI) was observed in 47 patients (43%) with a mortality of 19%. Severe leukopenia, prior steroid therapy and presence of co-infections were significant risk factors for development of PIV-LRTI in multivariate analysis. Prolonged viral shedding was frequently observed with a median duration of 14 days and up to 79 days, especially in patients after allogeneic SCT and with LRTI. Nosocomial transmission occurred in 47 patients. Phylogenetic analysis of isolated PIV strains and combination with clinical data enabled the identification of seven separate clusters of nosocomial transmission. In conclusion, we observed significant morbidity and mortality of PIV infection in hematology and transplant patients. The clinical impact of co-infections, the possibility of long-term viral shedding and frequent nosocomial transmission should be taken into account when designing infection control strategies. |
| doi_str_mv | 10.1371/journal.pone.0271756 |
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Isolated PIV strains were characterized by sequence analysis and nosocomial transmission was assessed including phylogenetic analysis of viral strains. 109 cases of PIV infection were identified, 75 in the setting of SCT. PIV type 3 (n = 68) was the most frequent subtype. PIV lower respiratory tract infection (LRTI) was observed in 47 patients (43%) with a mortality of 19%. Severe leukopenia, prior steroid therapy and presence of co-infections were significant risk factors for development of PIV-LRTI in multivariate analysis. Prolonged viral shedding was frequently observed with a median duration of 14 days and up to 79 days, especially in patients after allogeneic SCT and with LRTI. Nosocomial transmission occurred in 47 patients. Phylogenetic analysis of isolated PIV strains and combination with clinical data enabled the identification of seven separate clusters of nosocomial transmission. In conclusion, we observed significant morbidity and mortality of PIV infection in hematology and transplant patients. The clinical impact of co-infections, the possibility of long-term viral shedding and frequent nosocomial transmission should be taken into account when designing infection control strategies.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0271756</identifier><identifier>PMID: 35905071</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Analysis ; Biology and Life Sciences ; Blood diseases ; Computer and Information Sciences ; Coronaviruses ; Diagnosis ; Disease transmission ; Distribution ; Health risks ; Hematology ; Hospitals ; Immunocompromised hosts ; Infections ; Influenza ; Leukopenia ; Medicine and Health Sciences ; Morbidity ; Mortality ; Multivariate analysis ; Nosocomial infection ; Parainfluenza ; Patients ; Phylogenetics ; Phylogeny ; Proteins ; Respiratory syncytial virus ; Respiratory tract ; Respiratory tract diseases ; Risk analysis ; Risk factors ; Sequence analysis ; Severe acute respiratory syndrome coronavirus 2 ; Stem cell transplantation ; Stem cells ; Steroids ; Strains (organisms) ; Transplantation ; Viruses</subject><ispartof>PloS one, 2022-07, Vol.17 (7), p.e0271756-e0271756</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Tabatabai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Tabatabai et al 2022 Tabatabai et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c669t-89b70a7343ca99d5c0b786c058870643ad80a48d9ac36febe847d40442822fb3</citedby><cites>FETCH-LOGICAL-c669t-89b70a7343ca99d5c0b786c058870643ad80a48d9ac36febe847d40442822fb3</cites><orcidid>0000-0001-7351-8060 ; 0000-0003-3205-9464 ; 0000-0001-7791-8045</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337657/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337657/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids></links><search><creatorcontrib>Tabatabai, Julia</creatorcontrib><creatorcontrib>Schnitzler, Paul</creatorcontrib><creatorcontrib>Prifert, Christiane</creatorcontrib><creatorcontrib>Schiller, Martin</creatorcontrib><creatorcontrib>Weissbrich, Benedikt</creatorcontrib><creatorcontrib>von Lilienfeld-Toal, Marie</creatorcontrib><creatorcontrib>Teschner, Daniel</creatorcontrib><creatorcontrib>Jordan, Karin</creatorcontrib><creatorcontrib>Müller-Tidow, Carsten</creatorcontrib><creatorcontrib>Egerer, Gerlinde</creatorcontrib><creatorcontrib>Giesen, Nicola</creatorcontrib><title>Parainfluenza virus infections in patients with hematological malignancies or stem cell transplantation: Analysis of clinical characteristics, nosocomial transmission and viral shedding</title><title>PloS one</title><description>To assess morbidity and mortality of parainfluenza virus (PIV) infections in immunocompromised patients, we analysed PIV infections in a hematology and stem cell transplantation (SCT) unit over the course of three years. Isolated PIV strains were characterized by sequence analysis and nosocomial transmission was assessed including phylogenetic analysis of viral strains. 109 cases of PIV infection were identified, 75 in the setting of SCT. PIV type 3 (n = 68) was the most frequent subtype. PIV lower respiratory tract infection (LRTI) was observed in 47 patients (43%) with a mortality of 19%. Severe leukopenia, prior steroid therapy and presence of co-infections were significant risk factors for development of PIV-LRTI in multivariate analysis. Prolonged viral shedding was frequently observed with a median duration of 14 days and up to 79 days, especially in patients after allogeneic SCT and with LRTI. Nosocomial transmission occurred in 47 patients. Phylogenetic analysis of isolated PIV strains and combination with clinical data enabled the identification of seven separate clusters of nosocomial transmission. In conclusion, we observed significant morbidity and mortality of PIV infection in hematology and transplant patients. The clinical impact of co-infections, the possibility of long-term viral shedding and frequent nosocomial transmission should be taken into account when designing infection control strategies.</description><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Blood diseases</subject><subject>Computer and Information Sciences</subject><subject>Coronaviruses</subject><subject>Diagnosis</subject><subject>Disease transmission</subject><subject>Distribution</subject><subject>Health risks</subject><subject>Hematology</subject><subject>Hospitals</subject><subject>Immunocompromised hosts</subject><subject>Infections</subject><subject>Influenza</subject><subject>Leukopenia</subject><subject>Medicine and Health Sciences</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Multivariate analysis</subject><subject>Nosocomial 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morbidity and mortality of parainfluenza virus (PIV) infections in immunocompromised patients, we analysed PIV infections in a hematology and stem cell transplantation (SCT) unit over the course of three years. Isolated PIV strains were characterized by sequence analysis and nosocomial transmission was assessed including phylogenetic analysis of viral strains. 109 cases of PIV infection were identified, 75 in the setting of SCT. PIV type 3 (n = 68) was the most frequent subtype. PIV lower respiratory tract infection (LRTI) was observed in 47 patients (43%) with a mortality of 19%. Severe leukopenia, prior steroid therapy and presence of co-infections were significant risk factors for development of PIV-LRTI in multivariate analysis. Prolonged viral shedding was frequently observed with a median duration of 14 days and up to 79 days, especially in patients after allogeneic SCT and with LRTI. Nosocomial transmission occurred in 47 patients. Phylogenetic analysis of isolated PIV strains and combination with clinical data enabled the identification of seven separate clusters of nosocomial transmission. In conclusion, we observed significant morbidity and mortality of PIV infection in hematology and transplant patients. The clinical impact of co-infections, the possibility of long-term viral shedding and frequent nosocomial transmission should be taken into account when designing infection control strategies.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>35905071</pmid><doi>10.1371/journal.pone.0271756</doi><tpages>e0271756</tpages><orcidid>https://orcid.org/0000-0001-7351-8060</orcidid><orcidid>https://orcid.org/0000-0003-3205-9464</orcidid><orcidid>https://orcid.org/0000-0001-7791-8045</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2022-07, Vol.17 (7), p.e0271756-e0271756 |
| issn | 1932-6203 1932-6203 |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Analysis Biology and Life Sciences Blood diseases Computer and Information Sciences Coronaviruses Diagnosis Disease transmission Distribution Health risks Hematology Hospitals Immunocompromised hosts Infections Influenza Leukopenia Medicine and Health Sciences Morbidity Mortality Multivariate analysis Nosocomial infection Parainfluenza Patients Phylogenetics Phylogeny Proteins Respiratory syncytial virus Respiratory tract Respiratory tract diseases Risk analysis Risk factors Sequence analysis Severe acute respiratory syndrome coronavirus 2 Stem cell transplantation Stem cells Steroids Strains (organisms) Transplantation Viruses |
| title | Parainfluenza virus infections in patients with hematological malignancies or stem cell transplantation: Analysis of clinical characteristics, nosocomial transmission and viral shedding |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T01%3A37%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Parainfluenza%20virus%20infections%20in%20patients%20with%20hematological%20malignancies%20or%20stem%20cell%20transplantation:%20Analysis%20of%20clinical%20characteristics,%20nosocomial%20transmission%20and%20viral%20shedding&rft.jtitle=PloS%20one&rft.au=Tabatabai,%20Julia&rft.date=2022-07-29&rft.volume=17&rft.issue=7&rft.spage=e0271756&rft.epage=e0271756&rft.pages=e0271756-e0271756&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0271756&rft_dat=%3Cgale_plos_%3EA711930502%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2696472827&rft_id=info:pmid/35905071&rft_galeid=A711930502&rft_doaj_id=oai_doaj_org_article_55dc4e1ed7874c6282ab9145dd7ba2be&rfr_iscdi=true |