Optimization and evaluation of a live virus SARS-CoV-2 neutralization assay

Virus neutralization assays provide a means to quantitate functional antibody responses that block virus infection. These assays are instrumental in defining vaccine and therapeutic antibody potency, immune evasion by viral variants, and post-infection immunity. Here we describe the development, opt...

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Veröffentlicht in:	PloS one 2022-07, Vol.17 (7), p.e0272298
Hauptverfasser:	Frische, Anders, Brooks, Patrick Terrence, Gybel-Brask, Mikkel, Sækmose, Susanne Gjørup, Jensen, Bitten Aagaard, Mikkelsen, Susan, Bruun, Mie Topholm, Boding, Lasse, Strandh, Charlotta Polacek, Jørgensen, Charlotte Sværke, Krogfelt, Karen Angeliki, Fomsgaard, Anders, Lassauniere, Ria
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Neutralizing Antibodies, Viral Assaying Biology and life sciences Blood & organ donations Cell culture Clinical isolates Coronaviruses COVID-19 Enzyme-Linked Immunosorbent Assay Growth kinetics Humans Immune response Immunization Infections Influenza Inoculation Inoculum Medicine and health sciences Mutation Neutralization Neutralization Tests - methods Nucleocapsid Proteins Nucleocapsids Optimization Pandemics Penicillin Plasma Proteins Public health Research and Analysis Methods Respiratory diseases SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus Titration Vaccines Viral diseases Virus research Viruses
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