Antibiotic treatment duration for bloodstream infections in critically ill children—A survey of pediatric infectious diseases and critical care clinicians for clinical equipoise
To describe antibiotic treatment durations that pediatric infectious diseases (ID) and critical care clinicians usually recommend for bloodstream infections in critically ill children. Anonymous, online practice survey using five common pediatric-based case scenarios of bloodstream infections. Pedia...
Gespeichert in:
| Veröffentlicht in: | PloS one 2022-07, Vol.17 (7), p.e0272021-e0272021 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0272021 |
|---|---|
| container_issue | 7 |
| container_start_page | e0272021 |
| container_title | PloS one |
| container_volume | 17 |
| creator | Pong, Sandra Fowler, Robert A Murthy, Srinivas Pernica, Jeffrey M Gilfoyle, Elaine Fontela, Patricia Mitsakakis, Nicholas Bowen, Asha C Seto, Winnie Science, Michelle Hutchison, James S Jouvet, Philippe Rishu, Asgar Daneman, Nick |
| description | To describe antibiotic treatment durations that pediatric infectious diseases (ID) and critical care clinicians usually recommend for bloodstream infections in critically ill children. Anonymous, online practice survey using five common pediatric-based case scenarios of bloodstream infections. Pediatric intensive care units in Canada, Australia and New Zealand. Pediatric intensivists, nurse practitioners, ID physicians and pharmacists. Recommended treatment durations for common infectious syndromes associated with bloodstream infections and willingness to enrol patients into a trial to study treatment duration. Among 136 survey respondents, most recommended at least 10 days antibiotics for bloodstream infections associated with: pneumonia (65%), skin/soft tissue (74%), urinary tract (64%) and intra-abdominal infections (drained: 90%; undrained: 99%). For central vascular catheter-associated infections without catheter removal, over 90% clinicians recommended at least 10 days antibiotics, except for infections caused by coagulase negative staphylococci (79%). Recommendations for at least 10 days antibiotics were less common with catheter removal. In multivariable linear regression analyses, lack of source control was significantly associated with longer treatment durations (+5.2 days [95% CI: 4.4-6.1 days] for intra-abdominal infections and +4.1 days [95% CI: 3.8-4.4 days] for central vascular catheter-associated infections). Most clinicians (73-95%, depending on the source of bloodstream infection) would be willing to enrol patients into a trial of shorter versus longer antibiotic treatment duration. The majority of clinicians currently recommend at least 10 days of antibiotics for most scenarios of bloodstream infections in critically ill children. There is practice heterogeneity in self-reported treatment duration recommendations among clinicians. Treatment durations were similar across different infectious syndromes. Under appropriate clinical conditions, most clinicians would be willing to enrol patients into a trial of shorter versus longer treatment for common syndromes associated with bloodstream infections. |
| doi_str_mv | 10.1371/journal.pone.0272021 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2694902622</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A711554524</galeid><doaj_id>oai_doaj_org_article_28f3b04bc279448ca28fc3f18db21854</doaj_id><sourcerecordid>A711554524</sourcerecordid><originalsourceid>FETCH-LOGICAL-c669t-b43b9fab26bd88e4a77dc65c0b7fb6ab198389fa7ad5a5cffcc4c45d6632be853</originalsourceid><addsrcrecordid>eNqNk8tq3DAUQE1padK0f1CooFDaxUwtWZblTWEIfQwEAn1txdXDMxpkayLZodn1I_on_aN-SeWME-KSRfHC0r3nvnWz7DnOl7io8NudH0IHbrn3nVnmpCI5wQ-yY1wXZMFIXjy8cz7KnsS4y_Oy4Iw9zo6KknPMMD_Ofq-63krre6tQHwz0rel6pIcAvfUdanxA0nmv46hske0ao0ZNTEekgk124NwVss4htbVOB9P9-flrheIQLs0V8g3aG22hDynAjfUQkbbRQDQRQadv_SAFwSDlbGeVhRRjDH-4JqW5GOzeJ7un2aMGXDTPpv9J9u3D-6-nnxZn5x_Xp6uzhWKs7heSFrJuQBImNeeGQlVpxUqVy6qRDCSuecETUIEuoVRNoxRVtNSMFUQaXhYn2YuD373zUUz9joKwmtY5YYQkYn0gtIed2AfbQrgSHqy4FviwERBSac4IwptC5lQqUtWUcgVJoIoGcy0J5iVNvt5N0QbZGq3SHAK4mdO5prNbsfGXIg0ZUzKm-3pyEPzFYGIvWhuVcQ46k1p-yJvlNeUJffkPen91E7WBVEAank9x1ehUrCqMy5KWZMx7eQ-VPm1aq9LjbGySzwzezAwS05sf_QaGGMX6y-f_Z8-_z9lXd9itAddvo3fD9XOdg_QAquBjDKa5bTLOxbhbN90Q426JabeKv7MNG7M</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2694902622</pqid></control><display><type>article</type><title>Antibiotic treatment duration for bloodstream infections in critically ill children—A survey of pediatric infectious diseases and critical care clinicians for clinical equipoise</title><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Pong, Sandra ; Fowler, Robert A ; Murthy, Srinivas ; Pernica, Jeffrey M ; Gilfoyle, Elaine ; Fontela, Patricia ; Mitsakakis, Nicholas ; Bowen, Asha C ; Seto, Winnie ; Science, Michelle ; Hutchison, James S ; Jouvet, Philippe ; Rishu, Asgar ; Daneman, Nick</creator><contributor>Vadivelu, Jamunarani</contributor><creatorcontrib>Pong, Sandra ; Fowler, Robert A ; Murthy, Srinivas ; Pernica, Jeffrey M ; Gilfoyle, Elaine ; Fontela, Patricia ; Mitsakakis, Nicholas ; Bowen, Asha C ; Seto, Winnie ; Science, Michelle ; Hutchison, James S ; Jouvet, Philippe ; Rishu, Asgar ; Daneman, Nick ; Vadivelu, Jamunarani</creatorcontrib><description>To describe antibiotic treatment durations that pediatric infectious diseases (ID) and critical care clinicians usually recommend for bloodstream infections in critically ill children. Anonymous, online practice survey using five common pediatric-based case scenarios of bloodstream infections. Pediatric intensive care units in Canada, Australia and New Zealand. Pediatric intensivists, nurse practitioners, ID physicians and pharmacists. Recommended treatment durations for common infectious syndromes associated with bloodstream infections and willingness to enrol patients into a trial to study treatment duration. Among 136 survey respondents, most recommended at least 10 days antibiotics for bloodstream infections associated with: pneumonia (65%), skin/soft tissue (74%), urinary tract (64%) and intra-abdominal infections (drained: 90%; undrained: 99%). For central vascular catheter-associated infections without catheter removal, over 90% clinicians recommended at least 10 days antibiotics, except for infections caused by coagulase negative staphylococci (79%). Recommendations for at least 10 days antibiotics were less common with catheter removal. In multivariable linear regression analyses, lack of source control was significantly associated with longer treatment durations (+5.2 days [95% CI: 4.4-6.1 days] for intra-abdominal infections and +4.1 days [95% CI: 3.8-4.4 days] for central vascular catheter-associated infections). Most clinicians (73-95%, depending on the source of bloodstream infection) would be willing to enrol patients into a trial of shorter versus longer antibiotic treatment duration. The majority of clinicians currently recommend at least 10 days of antibiotics for most scenarios of bloodstream infections in critically ill children. There is practice heterogeneity in self-reported treatment duration recommendations among clinicians. Treatment durations were similar across different infectious syndromes. Under appropriate clinical conditions, most clinicians would be willing to enrol patients into a trial of shorter versus longer treatment for common syndromes associated with bloodstream infections.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0272021</identifier><identifier>PMID: 35881618</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Abdomen ; Adults ; Antibiotics ; Antimicrobial agents ; Biology and Life Sciences ; Catheters ; Children ; Coagulase ; Consent ; Critical care ; Critically ill children ; Disorders ; Drug stores ; Drug therapy ; Engineering and Technology ; Health services ; Heterogeneity ; Hospitals ; Infections ; Infectious diseases ; Intensive care ; Intensive care units ; Medical instruments ; Medical personnel ; Medicine and Health Sciences ; Mortality ; Multivariable control ; Participation ; Patients ; Pediatric research ; Pediatrics ; Pharmacists ; Physicians ; Pneumonia ; Polls & surveys ; Practice ; Privacy ; Regression analysis ; Research and Analysis Methods ; Response rates ; Sepsis ; Soft tissues ; Surveys ; Urinary tract ; Urogenital system</subject><ispartof>PloS one, 2022-07, Vol.17 (7), p.e0272021-e0272021</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Pong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Pong et al 2022 Pong et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c669t-b43b9fab26bd88e4a77dc65c0b7fb6ab198389fa7ad5a5cffcc4c45d6632be853</citedby><cites>FETCH-LOGICAL-c669t-b43b9fab26bd88e4a77dc65c0b7fb6ab198389fa7ad5a5cffcc4c45d6632be853</cites><orcidid>0000-0001-5684-3398 ; 0000-0002-4380-5402 ; 0000-0003-2963-9601</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321425/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321425/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53770,53772,79347,79348</link.rule.ids></links><search><contributor>Vadivelu, Jamunarani</contributor><creatorcontrib>Pong, Sandra</creatorcontrib><creatorcontrib>Fowler, Robert A</creatorcontrib><creatorcontrib>Murthy, Srinivas</creatorcontrib><creatorcontrib>Pernica, Jeffrey M</creatorcontrib><creatorcontrib>Gilfoyle, Elaine</creatorcontrib><creatorcontrib>Fontela, Patricia</creatorcontrib><creatorcontrib>Mitsakakis, Nicholas</creatorcontrib><creatorcontrib>Bowen, Asha C</creatorcontrib><creatorcontrib>Seto, Winnie</creatorcontrib><creatorcontrib>Science, Michelle</creatorcontrib><creatorcontrib>Hutchison, James S</creatorcontrib><creatorcontrib>Jouvet, Philippe</creatorcontrib><creatorcontrib>Rishu, Asgar</creatorcontrib><creatorcontrib>Daneman, Nick</creatorcontrib><title>Antibiotic treatment duration for bloodstream infections in critically ill children—A survey of pediatric infectious diseases and critical care clinicians for clinical equipoise</title><title>PloS one</title><description>To describe antibiotic treatment durations that pediatric infectious diseases (ID) and critical care clinicians usually recommend for bloodstream infections in critically ill children. Anonymous, online practice survey using five common pediatric-based case scenarios of bloodstream infections. Pediatric intensive care units in Canada, Australia and New Zealand. Pediatric intensivists, nurse practitioners, ID physicians and pharmacists. Recommended treatment durations for common infectious syndromes associated with bloodstream infections and willingness to enrol patients into a trial to study treatment duration. Among 136 survey respondents, most recommended at least 10 days antibiotics for bloodstream infections associated with: pneumonia (65%), skin/soft tissue (74%), urinary tract (64%) and intra-abdominal infections (drained: 90%; undrained: 99%). For central vascular catheter-associated infections without catheter removal, over 90% clinicians recommended at least 10 days antibiotics, except for infections caused by coagulase negative staphylococci (79%). Recommendations for at least 10 days antibiotics were less common with catheter removal. In multivariable linear regression analyses, lack of source control was significantly associated with longer treatment durations (+5.2 days [95% CI: 4.4-6.1 days] for intra-abdominal infections and +4.1 days [95% CI: 3.8-4.4 days] for central vascular catheter-associated infections). Most clinicians (73-95%, depending on the source of bloodstream infection) would be willing to enrol patients into a trial of shorter versus longer antibiotic treatment duration. The majority of clinicians currently recommend at least 10 days of antibiotics for most scenarios of bloodstream infections in critically ill children. There is practice heterogeneity in self-reported treatment duration recommendations among clinicians. Treatment durations were similar across different infectious syndromes. Under appropriate clinical conditions, most clinicians would be willing to enrol patients into a trial of shorter versus longer treatment for common syndromes associated with bloodstream infections.</description><subject>Abdomen</subject><subject>Adults</subject><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Biology and Life Sciences</subject><subject>Catheters</subject><subject>Children</subject><subject>Coagulase</subject><subject>Consent</subject><subject>Critical care</subject><subject>Critically ill children</subject><subject>Disorders</subject><subject>Drug stores</subject><subject>Drug therapy</subject><subject>Engineering and Technology</subject><subject>Health services</subject><subject>Heterogeneity</subject><subject>Hospitals</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Intensive care</subject><subject>Intensive care units</subject><subject>Medical instruments</subject><subject>Medical personnel</subject><subject>Medicine and Health Sciences</subject><subject>Mortality</subject><subject>Multivariable control</subject><subject>Participation</subject><subject>Patients</subject><subject>Pediatric research</subject><subject>Pediatrics</subject><subject>Pharmacists</subject><subject>Physicians</subject><subject>Pneumonia</subject><subject>Polls & surveys</subject><subject>Practice</subject><subject>Privacy</subject><subject>Regression analysis</subject><subject>Research and Analysis Methods</subject><subject>Response rates</subject><subject>Sepsis</subject><subject>Soft tissues</subject><subject>Surveys</subject><subject>Urinary tract</subject><subject>Urogenital system</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk8tq3DAUQE1padK0f1CooFDaxUwtWZblTWEIfQwEAn1txdXDMxpkayLZodn1I_on_aN-SeWME-KSRfHC0r3nvnWz7DnOl7io8NudH0IHbrn3nVnmpCI5wQ-yY1wXZMFIXjy8cz7KnsS4y_Oy4Iw9zo6KknPMMD_Ofq-63krre6tQHwz0rel6pIcAvfUdanxA0nmv46hske0ao0ZNTEekgk124NwVss4htbVOB9P9-flrheIQLs0V8g3aG22hDynAjfUQkbbRQDQRQadv_SAFwSDlbGeVhRRjDH-4JqW5GOzeJ7un2aMGXDTPpv9J9u3D-6-nnxZn5x_Xp6uzhWKs7heSFrJuQBImNeeGQlVpxUqVy6qRDCSuecETUIEuoVRNoxRVtNSMFUQaXhYn2YuD373zUUz9joKwmtY5YYQkYn0gtIed2AfbQrgSHqy4FviwERBSac4IwptC5lQqUtWUcgVJoIoGcy0J5iVNvt5N0QbZGq3SHAK4mdO5prNbsfGXIg0ZUzKm-3pyEPzFYGIvWhuVcQ46k1p-yJvlNeUJffkPen91E7WBVEAank9x1ehUrCqMy5KWZMx7eQ-VPm1aq9LjbGySzwzezAwS05sf_QaGGMX6y-f_Z8-_z9lXd9itAddvo3fD9XOdg_QAquBjDKa5bTLOxbhbN90Q426JabeKv7MNG7M</recordid><startdate>20220726</startdate><enddate>20220726</enddate><creator>Pong, Sandra</creator><creator>Fowler, Robert A</creator><creator>Murthy, Srinivas</creator><creator>Pernica, Jeffrey M</creator><creator>Gilfoyle, Elaine</creator><creator>Fontela, Patricia</creator><creator>Mitsakakis, Nicholas</creator><creator>Bowen, Asha C</creator><creator>Seto, Winnie</creator><creator>Science, Michelle</creator><creator>Hutchison, James S</creator><creator>Jouvet, Philippe</creator><creator>Rishu, Asgar</creator><creator>Daneman, Nick</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5684-3398</orcidid><orcidid>https://orcid.org/0000-0002-4380-5402</orcidid><orcidid>https://orcid.org/0000-0003-2963-9601</orcidid></search><sort><creationdate>20220726</creationdate><title>Antibiotic treatment duration for bloodstream infections in critically ill children—A survey of pediatric infectious diseases and critical care clinicians for clinical equipoise</title><author>Pong, Sandra ; Fowler, Robert A ; Murthy, Srinivas ; Pernica, Jeffrey M ; Gilfoyle, Elaine ; Fontela, Patricia ; Mitsakakis, Nicholas ; Bowen, Asha C ; Seto, Winnie ; Science, Michelle ; Hutchison, James S ; Jouvet, Philippe ; Rishu, Asgar ; Daneman, Nick</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c669t-b43b9fab26bd88e4a77dc65c0b7fb6ab198389fa7ad5a5cffcc4c45d6632be853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Abdomen</topic><topic>Adults</topic><topic>Antibiotics</topic><topic>Antimicrobial agents</topic><topic>Biology and Life Sciences</topic><topic>Catheters</topic><topic>Children</topic><topic>Coagulase</topic><topic>Consent</topic><topic>Critical care</topic><topic>Critically ill children</topic><topic>Disorders</topic><topic>Drug stores</topic><topic>Drug therapy</topic><topic>Engineering and Technology</topic><topic>Health services</topic><topic>Heterogeneity</topic><topic>Hospitals</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Intensive care</topic><topic>Intensive care units</topic><topic>Medical instruments</topic><topic>Medical personnel</topic><topic>Medicine and Health Sciences</topic><topic>Mortality</topic><topic>Multivariable control</topic><topic>Participation</topic><topic>Patients</topic><topic>Pediatric research</topic><topic>Pediatrics</topic><topic>Pharmacists</topic><topic>Physicians</topic><topic>Pneumonia</topic><topic>Polls & surveys</topic><topic>Practice</topic><topic>Privacy</topic><topic>Regression analysis</topic><topic>Research and Analysis Methods</topic><topic>Response rates</topic><topic>Sepsis</topic><topic>Soft tissues</topic><topic>Surveys</topic><topic>Urinary tract</topic><topic>Urogenital system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pong, Sandra</creatorcontrib><creatorcontrib>Fowler, Robert A</creatorcontrib><creatorcontrib>Murthy, Srinivas</creatorcontrib><creatorcontrib>Pernica, Jeffrey M</creatorcontrib><creatorcontrib>Gilfoyle, Elaine</creatorcontrib><creatorcontrib>Fontela, Patricia</creatorcontrib><creatorcontrib>Mitsakakis, Nicholas</creatorcontrib><creatorcontrib>Bowen, Asha C</creatorcontrib><creatorcontrib>Seto, Winnie</creatorcontrib><creatorcontrib>Science, Michelle</creatorcontrib><creatorcontrib>Hutchison, James S</creatorcontrib><creatorcontrib>Jouvet, Philippe</creatorcontrib><creatorcontrib>Rishu, Asgar</creatorcontrib><creatorcontrib>Daneman, Nick</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pong, Sandra</au><au>Fowler, Robert A</au><au>Murthy, Srinivas</au><au>Pernica, Jeffrey M</au><au>Gilfoyle, Elaine</au><au>Fontela, Patricia</au><au>Mitsakakis, Nicholas</au><au>Bowen, Asha C</au><au>Seto, Winnie</au><au>Science, Michelle</au><au>Hutchison, James S</au><au>Jouvet, Philippe</au><au>Rishu, Asgar</au><au>Daneman, Nick</au><au>Vadivelu, Jamunarani</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibiotic treatment duration for bloodstream infections in critically ill children—A survey of pediatric infectious diseases and critical care clinicians for clinical equipoise</atitle><jtitle>PloS one</jtitle><date>2022-07-26</date><risdate>2022</risdate><volume>17</volume><issue>7</issue><spage>e0272021</spage><epage>e0272021</epage><pages>e0272021-e0272021</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To describe antibiotic treatment durations that pediatric infectious diseases (ID) and critical care clinicians usually recommend for bloodstream infections in critically ill children. Anonymous, online practice survey using five common pediatric-based case scenarios of bloodstream infections. Pediatric intensive care units in Canada, Australia and New Zealand. Pediatric intensivists, nurse practitioners, ID physicians and pharmacists. Recommended treatment durations for common infectious syndromes associated with bloodstream infections and willingness to enrol patients into a trial to study treatment duration. Among 136 survey respondents, most recommended at least 10 days antibiotics for bloodstream infections associated with: pneumonia (65%), skin/soft tissue (74%), urinary tract (64%) and intra-abdominal infections (drained: 90%; undrained: 99%). For central vascular catheter-associated infections without catheter removal, over 90% clinicians recommended at least 10 days antibiotics, except for infections caused by coagulase negative staphylococci (79%). Recommendations for at least 10 days antibiotics were less common with catheter removal. In multivariable linear regression analyses, lack of source control was significantly associated with longer treatment durations (+5.2 days [95% CI: 4.4-6.1 days] for intra-abdominal infections and +4.1 days [95% CI: 3.8-4.4 days] for central vascular catheter-associated infections). Most clinicians (73-95%, depending on the source of bloodstream infection) would be willing to enrol patients into a trial of shorter versus longer antibiotic treatment duration. The majority of clinicians currently recommend at least 10 days of antibiotics for most scenarios of bloodstream infections in critically ill children. There is practice heterogeneity in self-reported treatment duration recommendations among clinicians. Treatment durations were similar across different infectious syndromes. Under appropriate clinical conditions, most clinicians would be willing to enrol patients into a trial of shorter versus longer treatment for common syndromes associated with bloodstream infections.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>35881618</pmid><doi>10.1371/journal.pone.0272021</doi><tpages>e0272021</tpages><orcidid>https://orcid.org/0000-0001-5684-3398</orcidid><orcidid>https://orcid.org/0000-0002-4380-5402</orcidid><orcidid>https://orcid.org/0000-0003-2963-9601</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2022-07, Vol.17 (7), p.e0272021-e0272021 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2694902622 |
| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abdomen Adults Antibiotics Antimicrobial agents Biology and Life Sciences Catheters Children Coagulase Consent Critical care Critically ill children Disorders Drug stores Drug therapy Engineering and Technology Health services Heterogeneity Hospitals Infections Infectious diseases Intensive care Intensive care units Medical instruments Medical personnel Medicine and Health Sciences Mortality Multivariable control Participation Patients Pediatric research Pediatrics Pharmacists Physicians Pneumonia Polls & surveys Practice Privacy Regression analysis Research and Analysis Methods Response rates Sepsis Soft tissues Surveys Urinary tract Urogenital system |
| title | Antibiotic treatment duration for bloodstream infections in critically ill children—A survey of pediatric infectious diseases and critical care clinicians for clinical equipoise |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T15%3A26%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antibiotic%20treatment%20duration%20for%20bloodstream%20infections%20in%20critically%20ill%20children%E2%80%94A%20survey%20of%20pediatric%20infectious%20diseases%20and%20critical%20care%20clinicians%20for%20clinical%20equipoise&rft.jtitle=PloS%20one&rft.au=Pong,%20Sandra&rft.date=2022-07-26&rft.volume=17&rft.issue=7&rft.spage=e0272021&rft.epage=e0272021&rft.pages=e0272021-e0272021&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0272021&rft_dat=%3Cgale_plos_%3EA711554524%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2694902622&rft_id=info:pmid/35881618&rft_galeid=A711554524&rft_doaj_id=oai_doaj_org_article_28f3b04bc279448ca28fc3f18db21854&rfr_iscdi=true |