Ultrasonographic and cytologic assessments of follicular neoplasms of the thyroid: Predictive features differentiating follicular carcinoma from follicular adenoma
Background The preoperative diagnosis of follicular neoplasm of the thyroid is challenging due to difficulties in the assessment of capsular invasion. This study aimed to identify ultrasonographic (US) and cytopathologic features that are characteristic of follicular adenoma and carcinoma to aid in...
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| Veröffentlicht in: | PloS one 2022-07, Vol.17 (7), p.e0271437-e0271437 |
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| description | Background The preoperative diagnosis of follicular neoplasm of the thyroid is challenging due to difficulties in the assessment of capsular invasion. This study aimed to identify ultrasonographic (US) and cytopathologic features that are characteristic of follicular adenoma and carcinoma to aid in their differential diagnosis. Methods A total of 98 surgically resected nodules diagnosed as follicular neoplasms between 2011 and 2012 were analyzed. US findings were reviewed according to the Korean Thyroid Imaging Reporting and Data System (K-TIRADS). Six cytologic features (high cellularity, abundant microfollicles, cell crowding/nuclear overlapping, isolated cells, homogeneous nuclei, abundant colloid) were reviewed quantitatively. The radiologic findings and quantification of cytologic features were correlated with final diagnoses. Results In total, 70 (71.4%) and 28 (28.6%) of the nodules were follicular adenomas and follicular carcinomas, respectively. US findings of a heterogeneous echogenicity, speculated/ill-defined margin, and presence of calcifications were significantly associated with follicular carcinoma (p |
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This study aimed to identify ultrasonographic (US) and cytopathologic features that are characteristic of follicular adenoma and carcinoma to aid in their differential diagnosis. Methods A total of 98 surgically resected nodules diagnosed as follicular neoplasms between 2011 and 2012 were analyzed. US findings were reviewed according to the Korean Thyroid Imaging Reporting and Data System (K-TIRADS). Six cytologic features (high cellularity, abundant microfollicles, cell crowding/nuclear overlapping, isolated cells, homogeneous nuclei, abundant colloid) were reviewed quantitatively. The radiologic findings and quantification of cytologic features were correlated with final diagnoses. Results In total, 70 (71.4%) and 28 (28.6%) of the nodules were follicular adenomas and follicular carcinomas, respectively. US findings of a heterogeneous echogenicity, speculated/ill-defined margin, and presence of calcifications were significantly associated with follicular carcinoma (p<0.05). Calcifications had a predilection for pericapsular areas than for stromal areas in follicular carcinomas, whereas their location was more varied in follicular adenomas. No cytologic feature was significantly different between follicular adenomas and carcinomas. Conclusion Distinct from follicular adenomas, follicular carcinomas are characterized by heterogeneous echogenicity, speculated/ill-defined margin, and presence of calcifications on US. Thus, US findings can be helpful to differentiate between these two follicular neoplasms.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0271437</identifier><identifier>PMID: 35862471</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Adenoma ; Biology and Life Sciences ; Biopsy ; Cancer ; Carcinoma ; Cellular biology ; Diagnosis ; Differential diagnosis ; Evaluation ; Medical diagnosis ; Medicine and Health Sciences ; Neoplasms ; Nodules ; Patients ; Reviews ; Risk factors ; Thyroid ; Thyroid cancer ; Thyroid gland ; Thyroidectomy ; Tumors ; Ultrasound imaging</subject><ispartof>PloS one, 2022-07, Vol.17 (7), p.e0271437-e0271437</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Ahn et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Ahn et al 2022 Ahn et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c669t-5846b8f7b05cd88dd7ff3f9b13d8f05f6b4b9084da8c133baa03920d4bb6ceb23</citedby><cites>FETCH-LOGICAL-c669t-5846b8f7b05cd88dd7ff3f9b13d8f05f6b4b9084da8c133baa03920d4bb6ceb23</cites><orcidid>0000-0002-8154-2391</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302718/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302718/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23847,27903,27904,53769,53771,79346,79347</link.rule.ids></links><search><contributor>Soares, Paula</contributor><creatorcontrib>Ahn, Hye Shin</creatorcontrib><creatorcontrib>Kim, Hee Sung</creatorcontrib><creatorcontrib>Hong, Min Ji</creatorcontrib><title>Ultrasonographic and cytologic assessments of follicular neoplasms of the thyroid: Predictive features differentiating follicular carcinoma from follicular adenoma</title><title>PloS one</title><description>Background The preoperative diagnosis of follicular neoplasm of the thyroid is challenging due to difficulties in the assessment of capsular invasion. This study aimed to identify ultrasonographic (US) and cytopathologic features that are characteristic of follicular adenoma and carcinoma to aid in their differential diagnosis. Methods A total of 98 surgically resected nodules diagnosed as follicular neoplasms between 2011 and 2012 were analyzed. US findings were reviewed according to the Korean Thyroid Imaging Reporting and Data System (K-TIRADS). Six cytologic features (high cellularity, abundant microfollicles, cell crowding/nuclear overlapping, isolated cells, homogeneous nuclei, abundant colloid) were reviewed quantitatively. The radiologic findings and quantification of cytologic features were correlated with final diagnoses. Results In total, 70 (71.4%) and 28 (28.6%) of the nodules were follicular adenomas and follicular carcinomas, respectively. US findings of a heterogeneous echogenicity, speculated/ill-defined margin, and presence of calcifications were significantly associated with follicular carcinoma (p<0.05). Calcifications had a predilection for pericapsular areas than for stromal areas in follicular carcinomas, whereas their location was more varied in follicular adenomas. No cytologic feature was significantly different between follicular adenomas and carcinomas. Conclusion Distinct from follicular adenomas, follicular carcinomas are characterized by heterogeneous echogenicity, speculated/ill-defined margin, and presence of calcifications on US. Thus, US findings can be helpful to differentiate between these two follicular neoplasms.</description><subject>Adenoma</subject><subject>Biology and Life Sciences</subject><subject>Biopsy</subject><subject>Cancer</subject><subject>Carcinoma</subject><subject>Cellular biology</subject><subject>Diagnosis</subject><subject>Differential diagnosis</subject><subject>Evaluation</subject><subject>Medical diagnosis</subject><subject>Medicine and Health Sciences</subject><subject>Neoplasms</subject><subject>Nodules</subject><subject>Patients</subject><subject>Reviews</subject><subject>Risk factors</subject><subject>Thyroid</subject><subject>Thyroid cancer</subject><subject>Thyroid gland</subject><subject>Thyroidectomy</subject><subject>Tumors</subject><subject>Ultrasound imaging</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk92K1DAUgIso7rr6BoIFQfRixjRJ09YLYVn8GVhYUdfbcJqfToa0mU3SxXkeX9R0p8qM7IWU0Pbky5fkJCfLnhdoWZCqeLtxox_ALrduUEuEq4KS6kF2WjQELxhG5OHB90n2JIQNQiWpGXucnZCyZphWxWn269pGD8ENrvOwXRuRwyBzsYvOum76C0GF0KshhtzpXDtrjRgt-HxQbmsh9HfxuFap7bwz8l3-xStpRDS3KtcK4uhVyKXRWvmkMRDN0B2KBHhhBtdDrr3rD3tAqin-NHukwQb1bH6fZdcfP3y_-Ly4vPq0uji_XAjGmrgoa8raWlctKoWsaykrrYlu2oLIWqNSs5a2DaqphFoUhLQAiDQYSdq2TKgWk7Psxd67tS7wOb-BY9ZgVtYYk0Ss9oR0sOFbb3rwO-7A8LuA8x0HH42wipNGoRJwIzBGlEIFmLRlU5OWSqpowZLr_Tzb2PZKipQbD_ZIetwzmDXv3C1vyHTadRK8ngXe3YwqRN6bIJS1kI5m3K-7KqsS0YS-_Ae9f3cz1UHagBm0S_OKScrPq6JA6dbhybW8h0qPVL0R6TJqk-JHA94cDUhMVD9jB2MIfPXt6_-zVz-O2VcH7FqBjevg7BiNG8IxSPeg8C4Er_TfJBeIT7X0Jxt8qiU-1xL5DcpfFEk</recordid><startdate>20220721</startdate><enddate>20220721</enddate><creator>Ahn, Hye 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and cytologic assessments of follicular neoplasms of the thyroid: Predictive features differentiating follicular carcinoma from follicular adenoma</title><author>Ahn, Hye Shin ; Kim, Hee Sung ; Hong, Min Ji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c669t-5846b8f7b05cd88dd7ff3f9b13d8f05f6b4b9084da8c133baa03920d4bb6ceb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adenoma</topic><topic>Biology and Life Sciences</topic><topic>Biopsy</topic><topic>Cancer</topic><topic>Carcinoma</topic><topic>Cellular biology</topic><topic>Diagnosis</topic><topic>Differential diagnosis</topic><topic>Evaluation</topic><topic>Medical diagnosis</topic><topic>Medicine and Health Sciences</topic><topic>Neoplasms</topic><topic>Nodules</topic><topic>Patients</topic><topic>Reviews</topic><topic>Risk factors</topic><topic>Thyroid</topic><topic>Thyroid cancer</topic><topic>Thyroid gland</topic><topic>Thyroidectomy</topic><topic>Tumors</topic><topic>Ultrasound imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahn, Hye Shin</creatorcontrib><creatorcontrib>Kim, Hee Sung</creatorcontrib><creatorcontrib>Hong, Min Ji</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids 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Ji</au><au>Soares, Paula</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultrasonographic and cytologic assessments of follicular neoplasms of the thyroid: Predictive features differentiating follicular carcinoma from follicular adenoma</atitle><jtitle>PloS one</jtitle><date>2022-07-21</date><risdate>2022</risdate><volume>17</volume><issue>7</issue><spage>e0271437</spage><epage>e0271437</epage><pages>e0271437-e0271437</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Background The preoperative diagnosis of follicular neoplasm of the thyroid is challenging due to difficulties in the assessment of capsular invasion. This study aimed to identify ultrasonographic (US) and cytopathologic features that are characteristic of follicular adenoma and carcinoma to aid in their differential diagnosis. Methods A total of 98 surgically resected nodules diagnosed as follicular neoplasms between 2011 and 2012 were analyzed. US findings were reviewed according to the Korean Thyroid Imaging Reporting and Data System (K-TIRADS). Six cytologic features (high cellularity, abundant microfollicles, cell crowding/nuclear overlapping, isolated cells, homogeneous nuclei, abundant colloid) were reviewed quantitatively. The radiologic findings and quantification of cytologic features were correlated with final diagnoses. Results In total, 70 (71.4%) and 28 (28.6%) of the nodules were follicular adenomas and follicular carcinomas, respectively. US findings of a heterogeneous echogenicity, speculated/ill-defined margin, and presence of calcifications were significantly associated with follicular carcinoma (p<0.05). Calcifications had a predilection for pericapsular areas than for stromal areas in follicular carcinomas, whereas their location was more varied in follicular adenomas. No cytologic feature was significantly different between follicular adenomas and carcinomas. Conclusion Distinct from follicular adenomas, follicular carcinomas are characterized by heterogeneous echogenicity, speculated/ill-defined margin, and presence of calcifications on US. Thus, US findings can be helpful to differentiate between these two follicular neoplasms.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>35862471</pmid><doi>10.1371/journal.pone.0271437</doi><tpages>e0271437</tpages><orcidid>https://orcid.org/0000-0002-8154-2391</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adenoma Biology and Life Sciences Biopsy Cancer Carcinoma Cellular biology Diagnosis Differential diagnosis Evaluation Medical diagnosis Medicine and Health Sciences Neoplasms Nodules Patients Reviews Risk factors Thyroid Thyroid cancer Thyroid gland Thyroidectomy Tumors Ultrasound imaging |
| title | Ultrasonographic and cytologic assessments of follicular neoplasms of the thyroid: Predictive features differentiating follicular carcinoma from follicular adenoma |
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