Pertussis toxin suppresses dendritic cell-mediated delivery of B. pertussis into lung-draining lymph nodes

The adenylate cyclase (ACT) and the pertussis (PT) toxins of Bordetella pertussis exert potent immunomodulatory activities that synergize to suppress host defense in the course of whooping cough pathogenesis. We compared the mouse lung infection capacities of B. pertussis (Bp) mutants (Bp AC-or Bp P...

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Veröffentlicht in:	PLoS pathogens 2022-06, Vol.18 (6), p.e1010577-e1010577
Hauptverfasser:	Klimova, Nela, Holubova, Jana, Streparola, Gaia, Tomala, Jakub, Brazdilova, Ludmila, Stanek, Ondrej, Bumba, Ladislav, Sebo, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Adenylate cyclase Antibodies Antigens Bacteria Biology and Life Sciences Bronchopulmonary infection Cell migration Chemokines Colonization Dendritic cells Enzymes Immune clearance Immune response Immune system Immunoglobulin G Immunomodulation Infections Kinases Leukocytes (neutrophilic) Lungs Lymph nodes Lymphatic system Lymphocytes Lymphocytes B Lymphocytes T Lymphoid tissue Medicine and Health Sciences Mutants Neutrophils Pathogenesis Pertussis Pertussis toxin Proteins Synergism Toxins Toxoids Vaccines Whooping cough
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