Functional changes in hemostasis during asexual and sexual parasitemia in a controlled human malaria infection

Decreased platelet count is an early phenomenon in asexual Plasmodium falciparum parasitemia, but its association with acute or long-term functional changes in platelets and coagulation is unknown. Moreover, the impact of gametocytemia on platelets and coagulation remains unclear. We investigated th...

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Veröffentlicht in:	PloS one 2022-07, Vol.17 (7), p.e0271527-e0271527
Hauptverfasser:	Huang, Shengshi, van der Heijden, Wouter, Reuling, Isaie J, Wan, Jun, Yan, Qiuting, de Laat - Kremers, Romy M. W, Van der Ven, Andre J, de Groot, Philip G, McCall, Matthew, Sauerwein, Robert W, Bousema, Teun, Roest, Mark, Ninivaggi, Marisa, de Mast, Quirijn, de Laat, Bas
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Anticoagulants Antigens Assaying Biology and Life Sciences Blood platelets Bone marrow Care and treatment Coagulation Collagen Complications and side effects Convalescence Endothelium Enzymes Flow cytometry Hemostasis Hemostatics Hyperreactivity Hypersensitivity Infection Infections Malaria Medicine and Health Sciences P-selectin Parasitemia Parasites Peptides Plasma Plasmodium falciparum Platelets Prothrombin Reactivity Thrombin Thrombocytopenia Vector-borne diseases Von Willebrand factor
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