Mechanisms of azole antifungal resistance in clinical isolates of Candida tropicalis

This study was designed to understand the molecular mechanisms of azole resistance in Candida tropicalis using genetic and bioinformatics approaches. Thirty-two azole-resistant and 10 azole-susceptible (S) clinical isolates of C. tropicalis were subjected to mutation analysis of the azole target gen...

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Veröffentlicht in:	PloS one 2022-07, Vol.17 (7), p.e0269721
Hauptverfasser:	Paul, Saikat, Shaw, Dipika, Joshi, Himanshu, Singh, Shreya, Chakrabarti, Arunaloke, Rudramurthy, Shivaprakash M, Ghosh, Anup K
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Analysis Antifungal agents Antifungal Agents - pharmacology Azoles - pharmacology Bioinformatics Biology and Life Sciences Biosynthesis Candida Candida tropicalis Clinical isolates Complementarity-determining region 1 Complementarity-determining region 3 Drug resistance in microorganisms Enzymes ERG11 gene Ergosterol Fungicides Gene expression Genes Genetic aspects Genetic transcription Homology Infections Medicine and Health Sciences Microbial Sensitivity Tests Molecular docking Molecular Docking Simulation Molecular modelling Mutation Physical Sciences Proteins Ribosomal DNA Sepsis Statistical analysis Transcription factors
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