Temporal changes in spike IgG levels after two doses of BNT162b2 vaccine in Japanese healthcare workers: Do spike IgG levels at 3 months predict levels 6 or 8 months after vaccination?
Accurate timing of BNT162b2 boosters to prevent breakthrough infections of coronavirus disease 2019 (COVID-19) requires reliable estimates of immune status. We hypothesized that spike IgG levels at 3 months after two doses of the BNT162b2 vaccine might predict subsequent spike IgG levels. Spike IgG...
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| Veröffentlicht in: | PloS one 2022-06, Vol.17 (6), p.e0263486-e0263486 |
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| creator | Takeuchi, Masaaki Esaki, Akina Higa, Yukie Nakazono, Akemi |
| description | Accurate timing of BNT162b2 boosters to prevent breakthrough infections of coronavirus disease 2019 (COVID-19) requires reliable estimates of immune status. We hypothesized that spike IgG levels at 3 months after two doses of the BNT162b2 vaccine might predict subsequent spike IgG levels. Spike IgG levels were tested at 3, 6, and 8 months after the second dose of the BNT162b2 vaccine in 251 Japanese health care workers (median age: 39 years, female: 187). We conclude that predictive formulae using spike IgG levels at 3 months after two-dose vaccination with BNT162b2 reliably estimate subsequent spike IgG levels up to 8 months and provide useful information in terms of vaccination booster timing. |
| doi_str_mv | 10.1371/journal.pone.0263486 |
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We hypothesized that spike IgG levels at 3 months after two doses of the BNT162b2 vaccine might predict subsequent spike IgG levels. Spike IgG levels were tested at 3, 6, and 8 months after the second dose of the BNT162b2 vaccine in 251 Japanese health care workers (median age: 39 years, female: 187). We conclude that predictive formulae using spike IgG levels at 3 months after two-dose vaccination with BNT162b2 reliably estimate subsequent spike IgG levels up to 8 months and provide useful information in terms of vaccination booster timing.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0263486</identifier><identifier>PMID: 35714162</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Antibodies ; Architects ; Biology and Life Sciences ; Coronaviruses ; Correlation ; COVID-19 ; COVID-19 vaccines ; Health aspects ; Health care ; Immune status ; Immunoglobulin G ; Infections ; Laboratories ; Medical personnel ; Medicine and Health Sciences ; Proteins ; Regression analysis ; Severe acute respiratory syndrome coronavirus 2 ; Vaccination ; Vaccines ; Viral diseases</subject><ispartof>PloS one, 2022-06, Vol.17 (6), p.e0263486-e0263486</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Takeuchi et al. 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Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takeuchi, Masaaki</au><au>Esaki, Akina</au><au>Higa, Yukie</au><au>Nakazono, Akemi</au><au>Ito, Etsuro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Temporal changes in spike IgG levels after two doses of BNT162b2 vaccine in Japanese healthcare workers: Do spike IgG levels at 3 months predict levels 6 or 8 months after vaccination?</atitle><jtitle>PloS one</jtitle><date>2022-06-17</date><risdate>2022</risdate><volume>17</volume><issue>6</issue><spage>e0263486</spage><epage>e0263486</epage><pages>e0263486-e0263486</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Accurate timing of BNT162b2 boosters to prevent breakthrough infections of coronavirus disease 2019 (COVID-19) requires reliable estimates of immune status. We hypothesized that spike IgG levels at 3 months after two doses of the BNT162b2 vaccine might predict subsequent spike IgG levels. Spike IgG levels were tested at 3, 6, and 8 months after the second dose of the BNT162b2 vaccine in 251 Japanese health care workers (median age: 39 years, female: 187). We conclude that predictive formulae using spike IgG levels at 3 months after two-dose vaccination with BNT162b2 reliably estimate subsequent spike IgG levels up to 8 months and provide useful information in terms of vaccination booster timing.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>35714162</pmid><doi>10.1371/journal.pone.0263486</doi><tpages>e0263486</tpages><orcidid>https://orcid.org/0000-0001-7606-1537</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antibodies Architects Biology and Life Sciences Coronaviruses Correlation COVID-19 COVID-19 vaccines Health aspects Health care Immune status Immunoglobulin G Infections Laboratories Medical personnel Medicine and Health Sciences Proteins Regression analysis Severe acute respiratory syndrome coronavirus 2 Vaccination Vaccines Viral diseases |
| title | Temporal changes in spike IgG levels after two doses of BNT162b2 vaccine in Japanese healthcare workers: Do spike IgG levels at 3 months predict levels 6 or 8 months after vaccination? |
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