EDTA salt modified carbon paste electrode for square wave voltammetric determination of theophylline in pharmaceutical tablet formulation
In this study, a square wave voltammetric method for determination of theophylline in tablet formulation based on EDTA salt modified carbon paste electrode is presented. CV, FT-IR, and EIS results confirmed modification of the carbon paste with EDTA salt. In contrast to the unmodified carbon paste e...
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| Veröffentlicht in: | PloS one 2022-06, Vol.17 (6), p.e0255700-e0255700 |
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| description | In this study, a square wave voltammetric method for determination of theophylline in tablet formulation based on EDTA salt modified carbon paste electrode is presented. CV, FT-IR, and EIS results confirmed modification of the carbon paste with EDTA salt. In contrast to the unmodified carbon paste electrode, the modified carbon paste electrode showed irreversible oxidation of theophylline with considerable current enhancement. Investigation of the effect of scan rate on the Ip and Ep response of the modified electrode for theophylline revealed predominantly diffusion controlled oxidation kinetics. Under the optimized conditions, square wave oxidative peak current of theophylline in pH 7.0 PBS showed linear dependence on concentration in the range 10-200 μM with determination coefficient (R2), limit of detection, and limit of quantification of 0.99782, 0.0257 μM, and 0.0857 μM, respectively. Detection of an amount of theophylline in the analyzed tablet formulation with 1.85% error from its nominal content (120 mg/tablet) confirmed the accuracy of the developed method. Spike and interference recovery results of 98.59%, and 95.7-100%, respectively validated the applicability of the developed method for determination of theophylline content in tablet samples. |
| doi_str_mv | 10.1371/journal.pone.0255700 |
| format | Article |
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CV, FT-IR, and EIS results confirmed modification of the carbon paste with EDTA salt. In contrast to the unmodified carbon paste electrode, the modified carbon paste electrode showed irreversible oxidation of theophylline with considerable current enhancement. Investigation of the effect of scan rate on the Ip and Ep response of the modified electrode for theophylline revealed predominantly diffusion controlled oxidation kinetics. Under the optimized conditions, square wave oxidative peak current of theophylline in pH 7.0 PBS showed linear dependence on concentration in the range 10-200 μM with determination coefficient (R2), limit of detection, and limit of quantification of 0.99782, 0.0257 μM, and 0.0857 μM, respectively. Detection of an amount of theophylline in the analyzed tablet formulation with 1.85% error from its nominal content (120 mg/tablet) confirmed the accuracy of the developed method. Spike and interference recovery results of 98.59%, and 95.7-100%, respectively validated the applicability of the developed method for determination of theophylline content in tablet samples.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0255700</identifier><identifier>PMID: 35687564</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Asthma ; Caffeine ; Carbon ; Carbon - chemistry ; Chromatography ; Chronic obstructive pulmonary disease ; Drug discovery ; Edetic Acid ; Electrodes ; Engineering and Technology ; Ethylenediaminetetraacetic acid ; Ethylenediaminetetraacetic acids ; Evaluation ; Fourier transforms ; Graphite ; Hydrogen-Ion Concentration ; Laboratories ; Nervous system ; Oxidation ; Pharmaceuticals ; Physical Sciences ; Properties ; Reaction kinetics ; Salts ; Spectroscopy, Fourier Transform Infrared ; Square waves ; Tablets ; Testing ; Theophylline ; Theophylline - chemistry ; Uric acid ; Voltammetry</subject><ispartof>PloS one, 2022-06, Vol.17 (6), p.e0255700-e0255700</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Moges et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Moges et al 2022 Moges et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-8e4bd1acb0bca23b7126b8eac0ae86639ccc55c9d5a877dd5ddecceb42cee8873</citedby><cites>FETCH-LOGICAL-c692t-8e4bd1acb0bca23b7126b8eac0ae86639ccc55c9d5a877dd5ddecceb42cee8873</cites><orcidid>0000-0001-8817-9508</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187066/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187066/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23868,27926,27927,53793,53795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35687564$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Sailor, Girish</contributor><creatorcontrib>Moges, Amsalu</creatorcontrib><creatorcontrib>Dawit, Mulugeta</creatorcontrib><creatorcontrib>Turbale, Mahilet</creatorcontrib><creatorcontrib>Amare, Meareg</creatorcontrib><title>EDTA salt modified carbon paste electrode for square wave voltammetric determination of theophylline in pharmaceutical tablet formulation</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>In this study, a square wave voltammetric method for determination of theophylline in tablet formulation based on EDTA salt modified carbon paste electrode is presented. CV, FT-IR, and EIS results confirmed modification of the carbon paste with EDTA salt. In contrast to the unmodified carbon paste electrode, the modified carbon paste electrode showed irreversible oxidation of theophylline with considerable current enhancement. Investigation of the effect of scan rate on the Ip and Ep response of the modified electrode for theophylline revealed predominantly diffusion controlled oxidation kinetics. Under the optimized conditions, square wave oxidative peak current of theophylline in pH 7.0 PBS showed linear dependence on concentration in the range 10-200 μM with determination coefficient (R2), limit of detection, and limit of quantification of 0.99782, 0.0257 μM, and 0.0857 μM, respectively. Detection of an amount of theophylline in the analyzed tablet formulation with 1.85% error from its nominal content (120 mg/tablet) confirmed the accuracy of the developed method. Spike and interference recovery results of 98.59%, and 95.7-100%, respectively validated the applicability of the developed method for determination of theophylline content in tablet samples.</description><subject>Analysis</subject><subject>Asthma</subject><subject>Caffeine</subject><subject>Carbon</subject><subject>Carbon - chemistry</subject><subject>Chromatography</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Drug discovery</subject><subject>Edetic Acid</subject><subject>Electrodes</subject><subject>Engineering and Technology</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Ethylenediaminetetraacetic acids</subject><subject>Evaluation</subject><subject>Fourier transforms</subject><subject>Graphite</subject><subject>Hydrogen-Ion Concentration</subject><subject>Laboratories</subject><subject>Nervous system</subject><subject>Oxidation</subject><subject>Pharmaceuticals</subject><subject>Physical Sciences</subject><subject>Properties</subject><subject>Reaction kinetics</subject><subject>Salts</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Square waves</subject><subject>Tablets</subject><subject>Testing</subject><subject>Theophylline</subject><subject>Theophylline - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moges, Amsalu</au><au>Dawit, Mulugeta</au><au>Turbale, Mahilet</au><au>Amare, Meareg</au><au>Sailor, Girish</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EDTA salt modified carbon paste electrode for square wave voltammetric determination of theophylline in pharmaceutical tablet formulation</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2022-06-10</date><risdate>2022</risdate><volume>17</volume><issue>6</issue><spage>e0255700</spage><epage>e0255700</epage><pages>e0255700-e0255700</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>In this study, a square wave voltammetric method for determination of theophylline in tablet formulation based on EDTA salt modified carbon paste electrode is presented. CV, FT-IR, and EIS results confirmed modification of the carbon paste with EDTA salt. In contrast to the unmodified carbon paste electrode, the modified carbon paste electrode showed irreversible oxidation of theophylline with considerable current enhancement. Investigation of the effect of scan rate on the Ip and Ep response of the modified electrode for theophylline revealed predominantly diffusion controlled oxidation kinetics. Under the optimized conditions, square wave oxidative peak current of theophylline in pH 7.0 PBS showed linear dependence on concentration in the range 10-200 μM with determination coefficient (R2), limit of detection, and limit of quantification of 0.99782, 0.0257 μM, and 0.0857 μM, respectively. Detection of an amount of theophylline in the analyzed tablet formulation with 1.85% error from its nominal content (120 mg/tablet) confirmed the accuracy of the developed method. Spike and interference recovery results of 98.59%, and 95.7-100%, respectively validated the applicability of the developed method for determination of theophylline content in tablet samples.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>35687564</pmid><doi>10.1371/journal.pone.0255700</doi><orcidid>https://orcid.org/0000-0001-8817-9508</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Asthma Caffeine Carbon Carbon - chemistry Chromatography Chronic obstructive pulmonary disease Drug discovery Edetic Acid Electrodes Engineering and Technology Ethylenediaminetetraacetic acid Ethylenediaminetetraacetic acids Evaluation Fourier transforms Graphite Hydrogen-Ion Concentration Laboratories Nervous system Oxidation Pharmaceuticals Physical Sciences Properties Reaction kinetics Salts Spectroscopy, Fourier Transform Infrared Square waves Tablets Testing Theophylline Theophylline - chemistry Uric acid Voltammetry |
| title | EDTA salt modified carbon paste electrode for square wave voltammetric determination of theophylline in pharmaceutical tablet formulation |
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