Comparison of functional-oil blend and anticoccidial antibiotics effects on performance and microbiota of broiler chickens challenged by coccidiosis
This study aimed to compare the effects of different levels of cashew nutshell liquid (CNSL) and castor oil (CNSL-castor oil) with growth-promoting antibiotics associated with anticoccidials in broiler chickens challenged with coccidiosis. In this work, 2520 one-day-old male broiler chicks (Cobb) we...
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| creator | Pires, Paula Gabriela da Silva Torres, Pedro Teixeira Soratto, Tatiany Aparecida Filho, Vilmar Benetti Hauptli, Lucélia Wagner, Glauber Haese, Douglas Pozzatti, Carolina D'ávila Moraes, Priscila de Oliveira |
| description | This study aimed to compare the effects of different levels of cashew nutshell liquid (CNSL) and castor oil (CNSL-castor oil) with growth-promoting antibiotics associated with anticoccidials in broiler chickens challenged with coccidiosis. In this work, 2520 one-day-old male broiler chicks (Cobb) were randomly assigned to 84 pens, containing 30 birds each. The experimental design was completely randomized, with seven treatments: enramycin (8 ppm), virginiamycin (16.5 ppm), and tylosin (55 ppm); different doses of CNSL-castor oil (0.5, 0.75, and 1.00 kg/t); and a control diet (without additives). All treatments received semduramicin + nicarbazin (500 g/t; Aviax® Plus) from 0 to 28 d and monensin sodium (100 ppm; Elanco) from 29 to 35 days of age, when the feed was without antibiotics. The challenge was introduced at 14 days of age by inoculating broiler chickens with sporulated Eimeria tenella, Eimeria acervulina, and Eimeria maxima oocysts via oral gavage. In addition to performance parameters, intestinal contents were collected at 28 and 42 days of age for microbiota analysis by sequencing the 16s rRNA in V3 and V4 regions using the Illumina MiSeq platform. Taxonomy was assigned using the SILVA database (v. 138) with QIIME2 software (v. 2020.11). After one week of challenge, the broilers that received tylosin had a higher body weight gain (BWG) than those in the control group (p < 0.05), while the other treatments presented intermediate values. At 28 d, the BWG was lower for the control, CNSL-Castor oil 0.5 kg/t, enramycin, and virginiamycin treatments than that in the tylosin treatment. The inclusion of CNSL-Castor oil at concentrations of 0.75 and 1 kg/t acted as an intermediate treatment (p < 0.05). For alpha diversity, using the Shannon index, it was possible to observe the effect of age, with substantial diversity at 42 d. The Firmicutes phylum had the highest abundance, with values between 84.33% and 95.16% at 42 d. Tylosin showed better performance indices than other treatments. CNSL-castor oil treatments with concentrations of 0.75 and 1 kg/t showed similar results to those of enramycin and virginiamycin. Furthermore, CNSL-castor oil acted as a modulator of intestinal microbiota, reducing the abundance of pathogenic bacteria. |
| doi_str_mv | 10.1371/journal.pone.0270350 |
| format | Article |
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In this work, 2520 one-day-old male broiler chicks (Cobb) were randomly assigned to 84 pens, containing 30 birds each. The experimental design was completely randomized, with seven treatments: enramycin (8 ppm), virginiamycin (16.5 ppm), and tylosin (55 ppm); different doses of CNSL-castor oil (0.5, 0.75, and 1.00 kg/t); and a control diet (without additives). All treatments received semduramicin + nicarbazin (500 g/t; Aviax® Plus) from 0 to 28 d and monensin sodium (100 ppm; Elanco) from 29 to 35 days of age, when the feed was without antibiotics. The challenge was introduced at 14 days of age by inoculating broiler chickens with sporulated Eimeria tenella, Eimeria acervulina, and Eimeria maxima oocysts via oral gavage. In addition to performance parameters, intestinal contents were collected at 28 and 42 days of age for microbiota analysis by sequencing the 16s rRNA in V3 and V4 regions using the Illumina MiSeq platform. Taxonomy was assigned using the SILVA database (v. 138) with QIIME2 software (v. 2020.11). After one week of challenge, the broilers that received tylosin had a higher body weight gain (BWG) than those in the control group (p < 0.05), while the other treatments presented intermediate values. At 28 d, the BWG was lower for the control, CNSL-Castor oil 0.5 kg/t, enramycin, and virginiamycin treatments than that in the tylosin treatment. The inclusion of CNSL-Castor oil at concentrations of 0.75 and 1 kg/t acted as an intermediate treatment (p < 0.05). For alpha diversity, using the Shannon index, it was possible to observe the effect of age, with substantial diversity at 42 d. The Firmicutes phylum had the highest abundance, with values between 84.33% and 95.16% at 42 d. Tylosin showed better performance indices than other treatments. CNSL-castor oil treatments with concentrations of 0.75 and 1 kg/t showed similar results to those of enramycin and virginiamycin. Furthermore, CNSL-castor oil acted as a modulator of intestinal microbiota, reducing the abundance of pathogenic bacteria.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0270350</identifier><identifier>PMID: 35793288</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Abundance ; Additives ; Age ; Age factors ; Animals ; Antibiotics ; Anticoccidials ; Biology and Life Sciences ; Birds ; Body weight ; Body weight gain ; Care and treatment ; Castor oil ; Chickens ; Coccidiosis ; Complications and side effects ; Design of experiments ; Experimental design ; Feeds ; Health aspects ; Intestinal microflora ; Intestine ; Medicine and Health Sciences ; Microbiota ; Microbiota (Symbiotic organisms) ; Monensin ; Oil ; Oocysts ; Patient outcomes ; Performance indices ; Poultry ; rRNA 16S ; Sodium ; Taxonomy ; Tylosin ; Virginiamycin</subject><ispartof>PloS one, 2022-07, Vol.17 (7), p.e0270350-e0270350</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Pires et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Pires et al 2022 Pires et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c669t-e65d184c6ec4fefb10813e7e11d42ee2b8a26965e647755e24fb38c54276800e3</citedby><cites>FETCH-LOGICAL-c669t-e65d184c6ec4fefb10813e7e11d42ee2b8a26965e647755e24fb38c54276800e3</cites><orcidid>0000-0001-6416-9436 ; 0000-0003-3026-6523 ; 0000-0003-0309-4877</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258845/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258845/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids></links><search><contributor>Kogut, Michael H.</contributor><creatorcontrib>Pires, Paula Gabriela da Silva</creatorcontrib><creatorcontrib>Torres, Pedro</creatorcontrib><creatorcontrib>Teixeira Soratto, Tatiany Aparecida</creatorcontrib><creatorcontrib>Filho, Vilmar Benetti</creatorcontrib><creatorcontrib>Hauptli, Lucélia</creatorcontrib><creatorcontrib>Wagner, Glauber</creatorcontrib><creatorcontrib>Haese, Douglas</creatorcontrib><creatorcontrib>Pozzatti, Carolina D'ávila</creatorcontrib><creatorcontrib>Moraes, Priscila de Oliveira</creatorcontrib><title>Comparison of functional-oil blend and anticoccidial antibiotics effects on performance and microbiota of broiler chickens challenged by coccidiosis</title><title>PloS one</title><description>This study aimed to compare the effects of different levels of cashew nutshell liquid (CNSL) and castor oil (CNSL-castor oil) with growth-promoting antibiotics associated with anticoccidials in broiler chickens challenged with coccidiosis. 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Furthermore, CNSL-castor oil acted as a modulator of intestinal microbiota, reducing the abundance of pathogenic bacteria.</description><subject>Abundance</subject><subject>Additives</subject><subject>Age</subject><subject>Age factors</subject><subject>Animals</subject><subject>Antibiotics</subject><subject>Anticoccidials</subject><subject>Biology and Life Sciences</subject><subject>Birds</subject><subject>Body weight</subject><subject>Body weight gain</subject><subject>Care and treatment</subject><subject>Castor oil</subject><subject>Chickens</subject><subject>Coccidiosis</subject><subject>Complications and side effects</subject><subject>Design of experiments</subject><subject>Experimental design</subject><subject>Feeds</subject><subject>Health aspects</subject><subject>Intestinal microflora</subject><subject>Intestine</subject><subject>Medicine and Health Sciences</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic 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Lucélia</au><au>Wagner, Glauber</au><au>Haese, Douglas</au><au>Pozzatti, Carolina D'ávila</au><au>Moraes, Priscila de Oliveira</au><au>Kogut, Michael H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of functional-oil blend and anticoccidial antibiotics effects on performance and microbiota of broiler chickens challenged by coccidiosis</atitle><jtitle>PloS one</jtitle><date>2022-07-06</date><risdate>2022</risdate><volume>17</volume><issue>7</issue><spage>e0270350</spage><epage>e0270350</epage><pages>e0270350-e0270350</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>This study aimed to compare the effects of different levels of cashew nutshell liquid (CNSL) and castor oil (CNSL-castor oil) with growth-promoting antibiotics associated with anticoccidials in broiler chickens challenged with coccidiosis. In this work, 2520 one-day-old male broiler chicks (Cobb) were randomly assigned to 84 pens, containing 30 birds each. The experimental design was completely randomized, with seven treatments: enramycin (8 ppm), virginiamycin (16.5 ppm), and tylosin (55 ppm); different doses of CNSL-castor oil (0.5, 0.75, and 1.00 kg/t); and a control diet (without additives). All treatments received semduramicin + nicarbazin (500 g/t; Aviax® Plus) from 0 to 28 d and monensin sodium (100 ppm; Elanco) from 29 to 35 days of age, when the feed was without antibiotics. The challenge was introduced at 14 days of age by inoculating broiler chickens with sporulated Eimeria tenella, Eimeria acervulina, and Eimeria maxima oocysts via oral gavage. In addition to performance parameters, intestinal contents were collected at 28 and 42 days of age for microbiota analysis by sequencing the 16s rRNA in V3 and V4 regions using the Illumina MiSeq platform. Taxonomy was assigned using the SILVA database (v. 138) with QIIME2 software (v. 2020.11). After one week of challenge, the broilers that received tylosin had a higher body weight gain (BWG) than those in the control group (p < 0.05), while the other treatments presented intermediate values. At 28 d, the BWG was lower for the control, CNSL-Castor oil 0.5 kg/t, enramycin, and virginiamycin treatments than that in the tylosin treatment. The inclusion of CNSL-Castor oil at concentrations of 0.75 and 1 kg/t acted as an intermediate treatment (p < 0.05). For alpha diversity, using the Shannon index, it was possible to observe the effect of age, with substantial diversity at 42 d. The Firmicutes phylum had the highest abundance, with values between 84.33% and 95.16% at 42 d. Tylosin showed better performance indices than other treatments. CNSL-castor oil treatments with concentrations of 0.75 and 1 kg/t showed similar results to those of enramycin and virginiamycin. Furthermore, CNSL-castor oil acted as a modulator of intestinal microbiota, reducing the abundance of pathogenic bacteria.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>35793288</pmid><doi>10.1371/journal.pone.0270350</doi><tpages>e0270350</tpages><orcidid>https://orcid.org/0000-0001-6416-9436</orcidid><orcidid>https://orcid.org/0000-0003-3026-6523</orcidid><orcidid>https://orcid.org/0000-0003-0309-4877</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2022-07, Vol.17 (7), p.e0270350-e0270350 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2686273033 |
| source | PMC (PubMed Central); DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Abundance Additives Age Age factors Animals Antibiotics Anticoccidials Biology and Life Sciences Birds Body weight Body weight gain Care and treatment Castor oil Chickens Coccidiosis Complications and side effects Design of experiments Experimental design Feeds Health aspects Intestinal microflora Intestine Medicine and Health Sciences Microbiota Microbiota (Symbiotic organisms) Monensin Oil Oocysts Patient outcomes Performance indices Poultry rRNA 16S Sodium Taxonomy Tylosin Virginiamycin |
| title | Comparison of functional-oil blend and anticoccidial antibiotics effects on performance and microbiota of broiler chickens challenged by coccidiosis |
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