Clinical outcome of Descemet membrane endothelial keratoplasty (DMEK) with imported donor corneas in eyes of Asian patients; endothelium‐in versus endothelium‐out method
Objective We investigated whether (1) imported pre-cut tissue is feasible for Descemet membrane endothelial keratoplasty (DMEK) in eyes of Asian patients, (2) the clinical outcome is comparable between the endothelium-in and endothelium-out methods, and (3) the corneal edema-induced anterior curvatu...
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description | Objective We investigated whether (1) imported pre-cut tissue is feasible for Descemet membrane endothelial keratoplasty (DMEK) in eyes of Asian patients, (2) the clinical outcome is comparable between the endothelium-in and endothelium-out methods, and (3) the corneal edema-induced anterior curvature changes may have an effect on the refractive error. Methods The medical records of 32 DMEK patients who underwent either the endothelium-out or endothelium-in method using imported pre-cut grafts with a 3-day pre-cut-to-use time were retrospectively analyzed. Fuchs' endothelial dystrophy (37.5%) and bullous keratopathy (62.5%) cases were included. The main clinical outcome measures were graft survival, best corrected visual acuity (BCVA), endothelial cell density (ECD), corneal thickness (CT), and complications. Correlation of the anterior curvature changes with refractive error was analyzed in the DMEK with cataract surgery group. Results The overall survival rate was 71.9%. Final graft failures were caused by rejection, glaucoma, and infection. Visual acuities improved by 89.3%. BCVA better than 20/40 and 20/20 was found in 75% and 28.6% of patients, respectively. The ECDs at 3 months and 1 year were 1400 and 1083 cells/mm.sup.2, respectively. The mean survival time, ECD, BCVA, CT, and complication rates were not different between the endothelium-in and endothelium-out methods. A hyperopic shift by +0.42 D was not related to the anterior curvature changes. Conclusion Imported pre-cut tissues with a [less than or equal to] 3-day pre-cut-to-use time are feasible for DMEK in the treatment of corneal endothelial edema in eyes of Asian patients, and both endothelium-in and endothelium-out methods appear to be comparatively effective. Edema-induced anterior curvature change may not affect the refractive shift. |
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fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2686271723</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A708717458</galeid><doaj_id>oai_doaj_org_article_c55eb813956b44d5881c2860b42cebd9</doaj_id><sourcerecordid>A708717458</sourcerecordid><originalsourceid>FETCH-LOGICAL-c570t-ea57a7c5c18dc02546de8c86b0edef759b11088f0707f1cc0ec83213e44490653</originalsourceid><addsrcrecordid>eNptkt1u0zAUxyMEYqPwBkhY4mZctPgjjh0hIVXdgIkhbuDacpyT1iWJg-0M9Y5H4EV4KZ4Edw0fnSbLsnX8P7_z4ZNlTwleECbIy60bfa_bxeB6WGAqMGbiXnZKSkbnBcXs_n_3k-xRCFuMOZNF8TA7YVwIIgk-zX6uWttbo1vkxmhcB8g16ByCgQ4i6qCrvO4BQV-7uIHWJuEX8Dq6odUh7tDZ-YeL9y_QNxs3yHaD8xFqVLveeWSc70EHZHsEOwh78DJY3aNBRwt9DK_-Ycfu1_cfSXgNPozhlj1lljKJG1c_zh40ug3wZDpn2ec3F59W7-ZXH99erpZXc8MFjnPQXGhhuCGyNpjyvKhBGllUGGpoBC8rQrCUDRZYNMQYDEYyShjkeV7igrNZ9uzAHVoX1NTpoGghCyqIoCwpLg-K2umtGrzttN8pp626MTi_VtpHa1pQhnOoJGElL6o8r7mUxFBZ4CqnBqq6TKzXU7Sx6qA2qTdet0fQ45febtTaXauS5gVlRQKcTQDvvo4Qoups-sG2TV_nxpu8qUgVpj3Lnt-S3l3dpFrrVIDtG5fimj1ULQWWSZTzPWtxhyqtGjpr0lg2NtmPHPKDg_EuBA_N3xoJVvuh_pOM2g-1moaa_QbUae-D</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2686271723</pqid></control><display><type>article</type><title>Clinical outcome of Descemet membrane endothelial keratoplasty (DMEK) with imported donor corneas in eyes of Asian patients; endothelium‐in versus endothelium‐out method</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Jung, Young-ho ; Yoon, Chang Ho ; Kim, Mee Kum</creator><creatorcontrib>Jung, Young-ho ; Yoon, Chang Ho ; Kim, Mee Kum</creatorcontrib><description>Objective We investigated whether (1) imported pre-cut tissue is feasible for Descemet membrane endothelial keratoplasty (DMEK) in eyes of Asian patients, (2) the clinical outcome is comparable between the endothelium-in and endothelium-out methods, and (3) the corneal edema-induced anterior curvature changes may have an effect on the refractive error. Methods The medical records of 32 DMEK patients who underwent either the endothelium-out or endothelium-in method using imported pre-cut grafts with a 3-day pre-cut-to-use time were retrospectively analyzed. Fuchs' endothelial dystrophy (37.5%) and bullous keratopathy (62.5%) cases were included. The main clinical outcome measures were graft survival, best corrected visual acuity (BCVA), endothelial cell density (ECD), corneal thickness (CT), and complications. Correlation of the anterior curvature changes with refractive error was analyzed in the DMEK with cataract surgery group. Results The overall survival rate was 71.9%. Final graft failures were caused by rejection, glaucoma, and infection. Visual acuities improved by 89.3%. BCVA better than 20/40 and 20/20 was found in 75% and 28.6% of patients, respectively. The ECDs at 3 months and 1 year were 1400 and 1083 cells/mm.sup.2, respectively. The mean survival time, ECD, BCVA, CT, and complication rates were not different between the endothelium-in and endothelium-out methods. A hyperopic shift by +0.42 D was not related to the anterior curvature changes. Conclusion Imported pre-cut tissues with a [less than or equal to] 3-day pre-cut-to-use time are feasible for DMEK in the treatment of corneal endothelial edema in eyes of Asian patients, and both endothelium-in and endothelium-out methods appear to be comparatively effective. Edema-induced anterior curvature change may not affect the refractive shift.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0270037</identifier><identifier>PMID: 35771810</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Acuity ; Biology and Life Sciences ; Cataracts ; Cell density ; Clinical outcomes ; Complications ; Cornea ; Corneal transplantation ; Curvature ; Dystrophy ; Edema ; Endothelial cells ; Endothelium ; Error analysis ; Eye ; Eye surgery ; Glaucoma ; Graft rejection ; Grafting ; Iris ; Medical records ; Medicine and Health Sciences ; Membranes ; Patients ; Review boards ; Social Sciences ; Survival ; Tomography ; Transplantation ; Visual acuity</subject><ispartof>PloS one, 2022-06, Vol.17 (6), p.e0270037-e0270037</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Jung et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Jung et al 2022 Jung et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-ea57a7c5c18dc02546de8c86b0edef759b11088f0707f1cc0ec83213e44490653</citedby><cites>FETCH-LOGICAL-c570t-ea57a7c5c18dc02546de8c86b0edef759b11088f0707f1cc0ec83213e44490653</cites><orcidid>0000-0001-7850-6894</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246236/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246236/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids></links><search><creatorcontrib>Jung, Young-ho</creatorcontrib><creatorcontrib>Yoon, Chang Ho</creatorcontrib><creatorcontrib>Kim, Mee Kum</creatorcontrib><title>Clinical outcome of Descemet membrane endothelial keratoplasty (DMEK) with imported donor corneas in eyes of Asian patients; endothelium‐in versus endothelium‐out method</title><title>PloS one</title><description>Objective We investigated whether (1) imported pre-cut tissue is feasible for Descemet membrane endothelial keratoplasty (DMEK) in eyes of Asian patients, (2) the clinical outcome is comparable between the endothelium-in and endothelium-out methods, and (3) the corneal edema-induced anterior curvature changes may have an effect on the refractive error. Methods The medical records of 32 DMEK patients who underwent either the endothelium-out or endothelium-in method using imported pre-cut grafts with a 3-day pre-cut-to-use time were retrospectively analyzed. Fuchs' endothelial dystrophy (37.5%) and bullous keratopathy (62.5%) cases were included. The main clinical outcome measures were graft survival, best corrected visual acuity (BCVA), endothelial cell density (ECD), corneal thickness (CT), and complications. Correlation of the anterior curvature changes with refractive error was analyzed in the DMEK with cataract surgery group. Results The overall survival rate was 71.9%. Final graft failures were caused by rejection, glaucoma, and infection. Visual acuities improved by 89.3%. BCVA better than 20/40 and 20/20 was found in 75% and 28.6% of patients, respectively. The ECDs at 3 months and 1 year were 1400 and 1083 cells/mm.sup.2, respectively. The mean survival time, ECD, BCVA, CT, and complication rates were not different between the endothelium-in and endothelium-out methods. A hyperopic shift by +0.42 D was not related to the anterior curvature changes. Conclusion Imported pre-cut tissues with a [less than or equal to] 3-day pre-cut-to-use time are feasible for DMEK in the treatment of corneal endothelial edema in eyes of Asian patients, and both endothelium-in and endothelium-out methods appear to be comparatively effective. Edema-induced anterior curvature change may not affect the refractive shift.</description><subject>Acuity</subject><subject>Biology and Life Sciences</subject><subject>Cataracts</subject><subject>Cell density</subject><subject>Clinical outcomes</subject><subject>Complications</subject><subject>Cornea</subject><subject>Corneal transplantation</subject><subject>Curvature</subject><subject>Dystrophy</subject><subject>Edema</subject><subject>Endothelial cells</subject><subject>Endothelium</subject><subject>Error analysis</subject><subject>Eye</subject><subject>Eye surgery</subject><subject>Glaucoma</subject><subject>Graft rejection</subject><subject>Grafting</subject><subject>Iris</subject><subject>Medical records</subject><subject>Medicine and Health Sciences</subject><subject>Membranes</subject><subject>Patients</subject><subject>Review boards</subject><subject>Social Sciences</subject><subject>Survival</subject><subject>Tomography</subject><subject>Transplantation</subject><subject>Visual 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outcome of Descemet membrane endothelial keratoplasty (DMEK) with imported donor corneas in eyes of Asian patients; endothelium‐in versus endothelium‐out method</title><author>Jung, Young-ho ; Yoon, Chang Ho ; Kim, Mee Kum</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c570t-ea57a7c5c18dc02546de8c86b0edef759b11088f0707f1cc0ec83213e44490653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acuity</topic><topic>Biology and Life Sciences</topic><topic>Cataracts</topic><topic>Cell density</topic><topic>Clinical outcomes</topic><topic>Complications</topic><topic>Cornea</topic><topic>Corneal transplantation</topic><topic>Curvature</topic><topic>Dystrophy</topic><topic>Edema</topic><topic>Endothelial cells</topic><topic>Endothelium</topic><topic>Error analysis</topic><topic>Eye</topic><topic>Eye surgery</topic><topic>Glaucoma</topic><topic>Graft rejection</topic><topic>Grafting</topic><topic>Iris</topic><topic>Medical records</topic><topic>Medicine and Health Sciences</topic><topic>Membranes</topic><topic>Patients</topic><topic>Review boards</topic><topic>Social Sciences</topic><topic>Survival</topic><topic>Tomography</topic><topic>Transplantation</topic><topic>Visual acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jung, Young-ho</creatorcontrib><creatorcontrib>Yoon, Chang Ho</creatorcontrib><creatorcontrib>Kim, Mee Kum</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jung, Young-ho</au><au>Yoon, Chang Ho</au><au>Kim, Mee Kum</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical outcome of Descemet membrane endothelial keratoplasty (DMEK) with imported donor corneas in eyes of Asian patients; endothelium‐in versus endothelium‐out method</atitle><jtitle>PloS one</jtitle><date>2022-06-30</date><risdate>2022</risdate><volume>17</volume><issue>6</issue><spage>e0270037</spage><epage>e0270037</epage><pages>e0270037-e0270037</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Objective We investigated whether (1) imported pre-cut tissue is feasible for Descemet membrane endothelial keratoplasty (DMEK) in eyes of Asian patients, (2) the clinical outcome is comparable between the endothelium-in and endothelium-out methods, and (3) the corneal edema-induced anterior curvature changes may have an effect on the refractive error. Methods The medical records of 32 DMEK patients who underwent either the endothelium-out or endothelium-in method using imported pre-cut grafts with a 3-day pre-cut-to-use time were retrospectively analyzed. Fuchs' endothelial dystrophy (37.5%) and bullous keratopathy (62.5%) cases were included. The main clinical outcome measures were graft survival, best corrected visual acuity (BCVA), endothelial cell density (ECD), corneal thickness (CT), and complications. Correlation of the anterior curvature changes with refractive error was analyzed in the DMEK with cataract surgery group. Results The overall survival rate was 71.9%. Final graft failures were caused by rejection, glaucoma, and infection. Visual acuities improved by 89.3%. BCVA better than 20/40 and 20/20 was found in 75% and 28.6% of patients, respectively. The ECDs at 3 months and 1 year were 1400 and 1083 cells/mm.sup.2, respectively. The mean survival time, ECD, BCVA, CT, and complication rates were not different between the endothelium-in and endothelium-out methods. A hyperopic shift by +0.42 D was not related to the anterior curvature changes. Conclusion Imported pre-cut tissues with a [less than or equal to] 3-day pre-cut-to-use time are feasible for DMEK in the treatment of corneal endothelial edema in eyes of Asian patients, and both endothelium-in and endothelium-out methods appear to be comparatively effective. Edema-induced anterior curvature change may not affect the refractive shift.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>35771810</pmid><doi>10.1371/journal.pone.0270037</doi><orcidid>https://orcid.org/0000-0001-7850-6894</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Acuity Biology and Life Sciences Cataracts Cell density Clinical outcomes Complications Cornea Corneal transplantation Curvature Dystrophy Edema Endothelial cells Endothelium Error analysis Eye Eye surgery Glaucoma Graft rejection Grafting Iris Medical records Medicine and Health Sciences Membranes Patients Review boards Social Sciences Survival Tomography Transplantation Visual acuity |
title | Clinical outcome of Descemet membrane endothelial keratoplasty (DMEK) with imported donor corneas in eyes of Asian patients; endothelium‐in versus endothelium‐out method |
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